The association between hippocampal subfield volumes and education in cognitively normal older adults and amnestic mild cognitive impairment patients

Dong Woo Kang,1 Hyun Kook Lim,2 Soo-hyun Joo,1 Na Rae Lee,1 Chang Uk Lee1 1Department of Psychiatry, Seoul St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, 2Department of Psychiatry, Yeoui-do St Mary’s Hospital, College of Medicine, The Catholic...

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Autores principales:	Kang DW, Lim HK, Joo SH, Lee NR, Lee CU
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	education hippocampus presubiculum subiculum mild cognitive impairment cognitive reserve Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/fdc763764f5743af967e783264532f4b
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spelling	oai:doaj.org-article:fdc763764f5743af967e783264532f4b2021-12-02T01:51:07ZThe association between hippocampal subfield volumes and education in cognitively normal older adults and amnestic mild cognitive impairment patients1178-2021https://doaj.org/article/fdc763764f5743af967e783264532f4b2018-01-01T00:00:00Zhttps://www.dovepress.com/the-association-between-hippocampal-subfield-volumes-and-education-in--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Dong Woo Kang,1 Hyun Kook Lim,2 Soo-hyun Joo,1 Na Rae Lee,1 Chang Uk Lee1 1Department of Psychiatry, Seoul St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, 2Department of Psychiatry, Yeoui-do St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea Objective: Previous research has indicated that there are potential associations between education and total hippocampal volume in the trajectory of Alzheimer’s disease (AD). However, the correlation between education and hippocampal subfield volumes in the progression of AD has yet to be understood. This study examined the relationship between education, which is a standard proxy for cognitive reserve, and hippocampal subfield volumes in healthy and amnestic mild cognitive impairment (aMCI) groups.Subjects and methods: Thirty-eight subjects with aMCI and 39 healthy control subjects underwent 3 T magnetic resonance imaging, and hippocampal subfield volumes were measured by automated segmentation. Multiple linear regression analysis was used to determine the association between education and hippocampal subfield volumes.Results: Education had a significant negative correlation with the left parasubiculum, presubiculum, and subiculum volumes in the aMCI group. In addition, multiple subfield volumes including left parasubiculum, left/right presubiculum, left cornus ammonis (CA)3, and left CA4 showed a significant correlation with the neuropsychological test scores in the control group and aMCI group.Conclusion: These findings contribute to a better understanding of the association between education, hippocampal subfield volumes, and amnestic cognitive functions in the early phase of AD. Keywords: education, hippocampus, presubiculum, subiculum, mild cognitive impairment, cognitive reserveKang DWLim HKJoo SHLee NRLee CUDove Medical Pressarticleeducationhippocampuspresubiculumsubiculummild cognitive impairmentcognitive reserveNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 143-152 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	education hippocampus presubiculum subiculum mild cognitive impairment cognitive reserve Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	education hippocampus presubiculum subiculum mild cognitive impairment cognitive reserve Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Kang DW Lim HK Joo SH Lee NR Lee CU The association between hippocampal subfield volumes and education in cognitively normal older adults and amnestic mild cognitive impairment patients
description	Dong Woo Kang,1 Hyun Kook Lim,2 Soo-hyun Joo,1 Na Rae Lee,1 Chang Uk Lee1 1Department of Psychiatry, Seoul St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, 2Department of Psychiatry, Yeoui-do St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea Objective: Previous research has indicated that there are potential associations between education and total hippocampal volume in the trajectory of Alzheimer’s disease (AD). However, the correlation between education and hippocampal subfield volumes in the progression of AD has yet to be understood. This study examined the relationship between education, which is a standard proxy for cognitive reserve, and hippocampal subfield volumes in healthy and amnestic mild cognitive impairment (aMCI) groups.Subjects and methods: Thirty-eight subjects with aMCI and 39 healthy control subjects underwent 3 T magnetic resonance imaging, and hippocampal subfield volumes were measured by automated segmentation. Multiple linear regression analysis was used to determine the association between education and hippocampal subfield volumes.Results: Education had a significant negative correlation with the left parasubiculum, presubiculum, and subiculum volumes in the aMCI group. In addition, multiple subfield volumes including left parasubiculum, left/right presubiculum, left cornus ammonis (CA)3, and left CA4 showed a significant correlation with the neuropsychological test scores in the control group and aMCI group.Conclusion: These findings contribute to a better understanding of the association between education, hippocampal subfield volumes, and amnestic cognitive functions in the early phase of AD. Keywords: education, hippocampus, presubiculum, subiculum, mild cognitive impairment, cognitive reserve
format	article
author	Kang DW Lim HK Joo SH Lee NR Lee CU
author_facet	Kang DW Lim HK Joo SH Lee NR Lee CU
author_sort	Kang DW
title	The association between hippocampal subfield volumes and education in cognitively normal older adults and amnestic mild cognitive impairment patients
title_short	The association between hippocampal subfield volumes and education in cognitively normal older adults and amnestic mild cognitive impairment patients
title_full	The association between hippocampal subfield volumes and education in cognitively normal older adults and amnestic mild cognitive impairment patients
title_fullStr	The association between hippocampal subfield volumes and education in cognitively normal older adults and amnestic mild cognitive impairment patients
title_full_unstemmed	The association between hippocampal subfield volumes and education in cognitively normal older adults and amnestic mild cognitive impairment patients
title_sort	association between hippocampal subfield volumes and education in cognitively normal older adults and amnestic mild cognitive impairment patients
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/fdc763764f5743af967e783264532f4b
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The association between hippocampal subfield volumes and education in cognitively normal older adults and amnestic mild cognitive impairment patients

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