Agomelatine versus fluoxetine in glycemic control and treating depressive and anxiety symptoms in type 2 diabetes mellitus subjects: a single-blind randomized controlled trial

Tingting Che,1 Xiaochun Teng,1 Qun Huang,1 Yanfei Mu,2 Xianjun Tang,2 Xiaosong Mu,2 Youneng Wei1 1Department of Endocrinology, Chongqing Public Health Medical Center, Chongqing, China; 2Chongqing Cancer Institute, Hospital and Cancer Center, Chongqing, China Background: Depressive and anxiety symp...

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Autores principales:	Che T, Teng X, Huang Q, Mu Y, Tang X, Mu X, Wei Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	fluoxetine agomelatine diabetes mellitus depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/fdcc0713ec9d441b8956ab0caf3a6843
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spelling	oai:doaj.org-article:fdcc0713ec9d441b8956ab0caf3a68432021-12-02T08:01:22ZAgomelatine versus fluoxetine in glycemic control and treating depressive and anxiety symptoms in type 2 diabetes mellitus subjects: a single-blind randomized controlled trial1178-2021https://doaj.org/article/fdcc0713ec9d441b8956ab0caf3a68432018-06-01T00:00:00Zhttps://www.dovepress.com/agomelatine-versus-fluoxetine-in-glycemic-control-and-treating-depress-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Tingting Che,1 Xiaochun Teng,1 Qun Huang,1 Yanfei Mu,2 Xianjun Tang,2 Xiaosong Mu,2 Youneng Wei1 1Department of Endocrinology, Chongqing Public Health Medical Center, Chongqing, China; 2Chongqing Cancer Institute, Hospital and Cancer Center, Chongqing, China Background: Depressive and anxiety symptoms could seriously affect the quality of life of type 2 diabetes mellitus (T2DM) subjects. Currently, little is known about the efficacy and acceptability of agomelatine versus fluoxetine in treating these symptoms in T2DM subjects. Therefore, this study was performed to find out which one was better in treating these symptoms in T2DM subjects.Materials and methods: T2DM subjects with depressive and anxiety symptoms were randomly assigned to receive either fluoxetine (30–40 mg/day) or agomelatine (25–50 mg/day). The treatment was continued for 12 weeks. The data of the Hamilton Depression Rating Scale (HDRS) and Hamilton Anxiety Rating Scale (HARS) were collected (at baseline and also at weeks 4, 8 and 12) to assess the depressive and anxiety symptoms, respectively. The metabolic parameters, including body mass index (BMI), fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c), were assessed at baseline and after 12 weeks of treatment. The treatment-related adverse events during the scheduled treatment period were recorded to compare the acceptability of these two drugs.Results: After 12 weeks of treatment, the average HDRS and HARS scores were significantly decreased in both groups. The average HDRS scores were not significantly different between the two groups, although the agomelatine group had a lower average HDRS score. The response and remission rates were similar between the two groups, and these two drugs had no significant effects on BMI and FPG. However, compared with the fluoxetine group, the agomelatine group had the significantly lower average HARS score (p=0.0017) and lower average HbA1c level (p<0.00001). Moreover, the incidence of adverse events was significantly lower in the agomelatine group than in the fluoxetine group (p=0.032).Conclusion: Both fluoxetine and agomelatine could effectively reduce depressive and anxiety symptoms in T2DM subjects, but agomelatine might be more effective and acceptable. Future studies with more subjects are needed to support and validate our conclusion. Keywords: fluoxetine, agomelatine, diabetes mellitus, depression Che TTeng XHuang QMu YTang XMu XWei YDove Medical Pressarticlefluoxetineagomelatinediabetes mellitusdepressionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 1527-1533 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	fluoxetine agomelatine diabetes mellitus depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	fluoxetine agomelatine diabetes mellitus depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Che T Teng X Huang Q Mu Y Tang X Mu X Wei Y Agomelatine versus fluoxetine in glycemic control and treating depressive and anxiety symptoms in type 2 diabetes mellitus subjects: a single-blind randomized controlled trial
description	Tingting Che,1 Xiaochun Teng,1 Qun Huang,1 Yanfei Mu,2 Xianjun Tang,2 Xiaosong Mu,2 Youneng Wei1 1Department of Endocrinology, Chongqing Public Health Medical Center, Chongqing, China; 2Chongqing Cancer Institute, Hospital and Cancer Center, Chongqing, China Background: Depressive and anxiety symptoms could seriously affect the quality of life of type 2 diabetes mellitus (T2DM) subjects. Currently, little is known about the efficacy and acceptability of agomelatine versus fluoxetine in treating these symptoms in T2DM subjects. Therefore, this study was performed to find out which one was better in treating these symptoms in T2DM subjects.Materials and methods: T2DM subjects with depressive and anxiety symptoms were randomly assigned to receive either fluoxetine (30–40 mg/day) or agomelatine (25–50 mg/day). The treatment was continued for 12 weeks. The data of the Hamilton Depression Rating Scale (HDRS) and Hamilton Anxiety Rating Scale (HARS) were collected (at baseline and also at weeks 4, 8 and 12) to assess the depressive and anxiety symptoms, respectively. The metabolic parameters, including body mass index (BMI), fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c), were assessed at baseline and after 12 weeks of treatment. The treatment-related adverse events during the scheduled treatment period were recorded to compare the acceptability of these two drugs.Results: After 12 weeks of treatment, the average HDRS and HARS scores were significantly decreased in both groups. The average HDRS scores were not significantly different between the two groups, although the agomelatine group had a lower average HDRS score. The response and remission rates were similar between the two groups, and these two drugs had no significant effects on BMI and FPG. However, compared with the fluoxetine group, the agomelatine group had the significantly lower average HARS score (p=0.0017) and lower average HbA1c level (p<0.00001). Moreover, the incidence of adverse events was significantly lower in the agomelatine group than in the fluoxetine group (p=0.032).Conclusion: Both fluoxetine and agomelatine could effectively reduce depressive and anxiety symptoms in T2DM subjects, but agomelatine might be more effective and acceptable. Future studies with more subjects are needed to support and validate our conclusion. Keywords: fluoxetine, agomelatine, diabetes mellitus, depression
format	article
author	Che T Teng X Huang Q Mu Y Tang X Mu X Wei Y
author_facet	Che T Teng X Huang Q Mu Y Tang X Mu X Wei Y
author_sort	Che T
title	Agomelatine versus fluoxetine in glycemic control and treating depressive and anxiety symptoms in type 2 diabetes mellitus subjects: a single-blind randomized controlled trial
title_short	Agomelatine versus fluoxetine in glycemic control and treating depressive and anxiety symptoms in type 2 diabetes mellitus subjects: a single-blind randomized controlled trial
title_full	Agomelatine versus fluoxetine in glycemic control and treating depressive and anxiety symptoms in type 2 diabetes mellitus subjects: a single-blind randomized controlled trial
title_fullStr	Agomelatine versus fluoxetine in glycemic control and treating depressive and anxiety symptoms in type 2 diabetes mellitus subjects: a single-blind randomized controlled trial
title_full_unstemmed	Agomelatine versus fluoxetine in glycemic control and treating depressive and anxiety symptoms in type 2 diabetes mellitus subjects: a single-blind randomized controlled trial
title_sort	agomelatine versus fluoxetine in glycemic control and treating depressive and anxiety symptoms in type 2 diabetes mellitus subjects: a single-blind randomized controlled trial
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/fdcc0713ec9d441b8956ab0caf3a6843
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Agomelatine versus fluoxetine in glycemic control and treating depressive and anxiety symptoms in type 2 diabetes mellitus subjects: a single-blind randomized controlled trial

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