Effect of loach paste on the liver and immune organs of D-galactose-induced ageing mice

We examined the effects of loach paste (LP) on liver and immune organs of d-galactose (DG)-induced aging mice. The results showed that LP can alleviate the atrophy of spleen and thymus, and restore the blood glucose levels. LP was particularly beneficial to liver. Liver indices and activities of asp...

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Autores principales:	Haiying Liu, Xinli Pei, Jing Wang, Yang Zhou, Limei Wang, Bin Qi
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	loach paste oxidation resistance liver damage gene expression Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/fdcc2483667b437a80fa240a1f81c59c
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spelling	oai:doaj.org-article:fdcc2483667b437a80fa240a1f81c59c2021-11-26T11:19:46ZEffect of loach paste on the liver and immune organs of D-galactose-induced ageing mice0954-01051465-344310.1080/09540105.2017.1376037https://doaj.org/article/fdcc2483667b437a80fa240a1f81c59c2018-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09540105.2017.1376037https://doaj.org/toc/0954-0105https://doaj.org/toc/1465-3443We examined the effects of loach paste (LP) on liver and immune organs of d-galactose (DG)-induced aging mice. The results showed that LP can alleviate the atrophy of spleen and thymus, and restore the blood glucose levels. LP was particularly beneficial to liver. Liver indices and activities of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase reduced with high doses of LP. Moreover, LP can improve the antioxidant system in liver by increasing the activities of total superoxide dismutase, glutathione peroxidase, and catalase, reducing malondialdehyde concentration. Furthermore, LP can improve immunity and reduce the inflammation of liver. The swelling of liver cells was alleviated and the cell arrangement returned to normal in the LP group. In addition, gene expressions of HSP70 and tumour necrosis factor-α (TNF-α) in liver which can promote inflammatory cytokine decreased significantly. Thus, regular LP intake effectively relieved DG-induced oxidative stress and alleviated liver and immune organs damage.Haiying LiuXinli PeiJing WangYang ZhouLimei WangBin QiTaylor & Francis Grouparticleloach pasteoxidation resistanceliver damagegene expressionAgriculture (General)S1-972Immunologic diseases. AllergyRC581-607ENFood and Agricultural Immunology, Vol 29, Iss 1, Pp 316-331 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	loach paste oxidation resistance liver damage gene expression Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
spellingShingle	loach paste oxidation resistance liver damage gene expression Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607 Haiying Liu Xinli Pei Jing Wang Yang Zhou Limei Wang Bin Qi Effect of loach paste on the liver and immune organs of D-galactose-induced ageing mice
description	We examined the effects of loach paste (LP) on liver and immune organs of d-galactose (DG)-induced aging mice. The results showed that LP can alleviate the atrophy of spleen and thymus, and restore the blood glucose levels. LP was particularly beneficial to liver. Liver indices and activities of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase reduced with high doses of LP. Moreover, LP can improve the antioxidant system in liver by increasing the activities of total superoxide dismutase, glutathione peroxidase, and catalase, reducing malondialdehyde concentration. Furthermore, LP can improve immunity and reduce the inflammation of liver. The swelling of liver cells was alleviated and the cell arrangement returned to normal in the LP group. In addition, gene expressions of HSP70 and tumour necrosis factor-α (TNF-α) in liver which can promote inflammatory cytokine decreased significantly. Thus, regular LP intake effectively relieved DG-induced oxidative stress and alleviated liver and immune organs damage.
format	article
author	Haiying Liu Xinli Pei Jing Wang Yang Zhou Limei Wang Bin Qi
author_facet	Haiying Liu Xinli Pei Jing Wang Yang Zhou Limei Wang Bin Qi
author_sort	Haiying Liu
title	Effect of loach paste on the liver and immune organs of D-galactose-induced ageing mice
title_short	Effect of loach paste on the liver and immune organs of D-galactose-induced ageing mice
title_full	Effect of loach paste on the liver and immune organs of D-galactose-induced ageing mice
title_fullStr	Effect of loach paste on the liver and immune organs of D-galactose-induced ageing mice
title_full_unstemmed	Effect of loach paste on the liver and immune organs of D-galactose-induced ageing mice
title_sort	effect of loach paste on the liver and immune organs of d-galactose-induced ageing mice
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/fdcc2483667b437a80fa240a1f81c59c
work_keys_str_mv	AT haiyingliu effectofloachpasteontheliverandimmuneorgansofdgalactoseinducedageingmice AT xinlipei effectofloachpasteontheliverandimmuneorgansofdgalactoseinducedageingmice AT jingwang effectofloachpasteontheliverandimmuneorgansofdgalactoseinducedageingmice AT yangzhou effectofloachpasteontheliverandimmuneorgansofdgalactoseinducedageingmice AT limeiwang effectofloachpasteontheliverandimmuneorgansofdgalactoseinducedageingmice AT binqi effectofloachpasteontheliverandimmuneorgansofdgalactoseinducedageingmice
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Effect of loach paste on the liver and immune organs of D-galactose-induced ageing mice

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