Integrated cross-study datasets of genetic dependencies in cancer

The integration of independent pan-cancer CRISPR-Cas9 datasets allows better representation of genomic heterogeneity across different cancer types. Here, the authors propose a strategy for the integration of two large CRISPR-Cas9 screens and report increased coverage of molecular diversity and genet...

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Autores principales:	Clare Pacini, Joshua M. Dempster, Isabella Boyle, Emanuel Gonçalves, Hanna Najgebauer, Emre Karakoc, Dieudonne van der Meer, Andrew Barthorpe, Howard Lightfoot, Patricia Jaaks, James M. McFarland, Mathew J. Garnett, Aviad Tsherniak, Francesco Iorio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fdd2ad5966004da891cf74b4446afacf
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spelling	oai:doaj.org-article:fdd2ad5966004da891cf74b4446afacf2021-12-02T15:52:21ZIntegrated cross-study datasets of genetic dependencies in cancer10.1038/s41467-021-21898-72041-1723https://doaj.org/article/fdd2ad5966004da891cf74b4446afacf2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21898-7https://doaj.org/toc/2041-1723The integration of independent pan-cancer CRISPR-Cas9 datasets allows better representation of genomic heterogeneity across different cancer types. Here, the authors propose a strategy for the integration of two large CRISPR-Cas9 screens and report increased coverage of molecular diversity and genetic dependencies.Clare PaciniJoshua M. DempsterIsabella BoyleEmanuel GonçalvesHanna NajgebauerEmre KarakocDieudonne van der MeerAndrew BarthorpeHoward LightfootPatricia JaaksJames M. McFarlandMathew J. GarnettAviad TsherniakFrancesco IorioNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Clare Pacini Joshua M. Dempster Isabella Boyle Emanuel Gonçalves Hanna Najgebauer Emre Karakoc Dieudonne van der Meer Andrew Barthorpe Howard Lightfoot Patricia Jaaks James M. McFarland Mathew J. Garnett Aviad Tsherniak Francesco Iorio Integrated cross-study datasets of genetic dependencies in cancer
description	The integration of independent pan-cancer CRISPR-Cas9 datasets allows better representation of genomic heterogeneity across different cancer types. Here, the authors propose a strategy for the integration of two large CRISPR-Cas9 screens and report increased coverage of molecular diversity and genetic dependencies.
format	article
author	Clare Pacini Joshua M. Dempster Isabella Boyle Emanuel Gonçalves Hanna Najgebauer Emre Karakoc Dieudonne van der Meer Andrew Barthorpe Howard Lightfoot Patricia Jaaks James M. McFarland Mathew J. Garnett Aviad Tsherniak Francesco Iorio
author_facet	Clare Pacini Joshua M. Dempster Isabella Boyle Emanuel Gonçalves Hanna Najgebauer Emre Karakoc Dieudonne van der Meer Andrew Barthorpe Howard Lightfoot Patricia Jaaks James M. McFarland Mathew J. Garnett Aviad Tsherniak Francesco Iorio
author_sort	Clare Pacini
title	Integrated cross-study datasets of genetic dependencies in cancer
title_short	Integrated cross-study datasets of genetic dependencies in cancer
title_full	Integrated cross-study datasets of genetic dependencies in cancer
title_fullStr	Integrated cross-study datasets of genetic dependencies in cancer
title_full_unstemmed	Integrated cross-study datasets of genetic dependencies in cancer
title_sort	integrated cross-study datasets of genetic dependencies in cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fdd2ad5966004da891cf74b4446afacf
work_keys_str_mv	AT clarepacini integratedcrossstudydatasetsofgeneticdependenciesincancer AT joshuamdempster integratedcrossstudydatasetsofgeneticdependenciesincancer AT isabellaboyle integratedcrossstudydatasetsofgeneticdependenciesincancer AT emanuelgoncalves integratedcrossstudydatasetsofgeneticdependenciesincancer AT hannanajgebauer integratedcrossstudydatasetsofgeneticdependenciesincancer AT emrekarakoc integratedcrossstudydatasetsofgeneticdependenciesincancer AT dieudonnevandermeer integratedcrossstudydatasetsofgeneticdependenciesincancer AT andrewbarthorpe integratedcrossstudydatasetsofgeneticdependenciesincancer AT howardlightfoot integratedcrossstudydatasetsofgeneticdependenciesincancer AT patriciajaaks integratedcrossstudydatasetsofgeneticdependenciesincancer AT jamesmmcfarland integratedcrossstudydatasetsofgeneticdependenciesincancer AT mathewjgarnett integratedcrossstudydatasetsofgeneticdependenciesincancer AT aviadtsherniak integratedcrossstudydatasetsofgeneticdependenciesincancer AT francescoiorio integratedcrossstudydatasetsofgeneticdependenciesincancer
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Integrated cross-study datasets of genetic dependencies in cancer

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