Identifying Mucormycosis Severity in Indian COVID-19 Patients: A Nano-Based Diagnosis and the Necessity for Critical Therapeutic Intervention

The COVID-19 infection caused by the new SARS-CoV-2 virus has been linked to a broad spectrum of symptoms, from a mild cough to life-threatening pneumonia. As we learn more about this unusual COVID-19 epidemic, new issues are emerging and being reported daily. Mucormycosis, also known as zygomycosis...

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Autores principales:	Syed Mohammed Basheeruddin Asdaq, Arya Rajan, Aswin Damodaran, Shivali R. Kamath, Krishnanjana S. Nair, Subin Mary Zachariah, Ram Kumar Sahu, Santosh Fattepur, Nagaraja Sreeharsha, Anroop Nair, Shery Jacob, Hussain A. Albahrani, Eman H. Alkhaldi, Yahya Mohzari, Ahmed A. Alrashed, Mohd. Imran
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	COVID-19 mucormycosis nanotechnology antifungal diabetes diagnosis Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/fdd41567703c452e88a45bbee7c93556
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spelling	oai:doaj.org-article:fdd41567703c452e88a45bbee7c935562021-11-25T16:22:31ZIdentifying Mucormycosis Severity in Indian COVID-19 Patients: A Nano-Based Diagnosis and the Necessity for Critical Therapeutic Intervention10.3390/antibiotics101113082079-6382https://doaj.org/article/fdd41567703c452e88a45bbee7c935562021-10-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1308https://doaj.org/toc/2079-6382The COVID-19 infection caused by the new SARS-CoV-2 virus has been linked to a broad spectrum of symptoms, from a mild cough to life-threatening pneumonia. As we learn more about this unusual COVID-19 epidemic, new issues are emerging and being reported daily. Mucormycosis, also known as zygomycosis or phycomycosis, causes severe fungal illness to individuals with a weakened immune system. It is a devastating fungal infection, and the most frequent kind is the rhino cerebral type. As a devastating second wave of COVID-19 sweeps India, doctors report several instances involving a strange illness—sometimes known as the “black fungus”—among returning and recovered COVID-19 patients. This paper analyzes the existing statistical data to address the severity of prevalence and further notes the nano-based diagnostic parameters, clinical presentations, its connection with other conditions like diabetes, hypertension, and GI disorders, and the importance of anti-fungal therapy in treating the same. Anti-fungal therapies, as well as surgical interventions, are currently used for the treatment of the disease. Proper and timely diagnosis is necessary, along with the reduction in the spread of COVID-19. From the review, it was found that timely pharmacologic interventions and early diagnosis by using a nano-based diagnostic kit can help control the disease. Additionally, this paper provides novel information about the nanotechnology approaches such as fungal detection biosensors, nucleic acids-based testing, point-of-care tests, and galactomannans detection, in the diagnosis of mucormycosis, and thereby reinforces the need for further research on the topic.Syed Mohammed Basheeruddin AsdaqArya RajanAswin DamodaranShivali R. KamathKrishnanjana S. NairSubin Mary ZachariahRam Kumar SahuSantosh FattepurNagaraja SreeharshaAnroop NairShery JacobHussain A. AlbahraniEman H. AlkhaldiYahya MohzariAhmed A. AlrashedMohd. ImranMDPI AGarticleCOVID-19mucormycosisnanotechnologyantifungaldiabetesdiagnosisTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1308, p 1308 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 mucormycosis nanotechnology antifungal diabetes diagnosis Therapeutics. Pharmacology RM1-950
spellingShingle	COVID-19 mucormycosis nanotechnology antifungal diabetes diagnosis Therapeutics. Pharmacology RM1-950 Syed Mohammed Basheeruddin Asdaq Arya Rajan Aswin Damodaran Shivali R. Kamath Krishnanjana S. Nair Subin Mary Zachariah Ram Kumar Sahu Santosh Fattepur Nagaraja Sreeharsha Anroop Nair Shery Jacob Hussain A. Albahrani Eman H. Alkhaldi Yahya Mohzari Ahmed A. Alrashed Mohd. Imran Identifying Mucormycosis Severity in Indian COVID-19 Patients: A Nano-Based Diagnosis and the Necessity for Critical Therapeutic Intervention
description	The COVID-19 infection caused by the new SARS-CoV-2 virus has been linked to a broad spectrum of symptoms, from a mild cough to life-threatening pneumonia. As we learn more about this unusual COVID-19 epidemic, new issues are emerging and being reported daily. Mucormycosis, also known as zygomycosis or phycomycosis, causes severe fungal illness to individuals with a weakened immune system. It is a devastating fungal infection, and the most frequent kind is the rhino cerebral type. As a devastating second wave of COVID-19 sweeps India, doctors report several instances involving a strange illness—sometimes known as the “black fungus”—among returning and recovered COVID-19 patients. This paper analyzes the existing statistical data to address the severity of prevalence and further notes the nano-based diagnostic parameters, clinical presentations, its connection with other conditions like diabetes, hypertension, and GI disorders, and the importance of anti-fungal therapy in treating the same. Anti-fungal therapies, as well as surgical interventions, are currently used for the treatment of the disease. Proper and timely diagnosis is necessary, along with the reduction in the spread of COVID-19. From the review, it was found that timely pharmacologic interventions and early diagnosis by using a nano-based diagnostic kit can help control the disease. Additionally, this paper provides novel information about the nanotechnology approaches such as fungal detection biosensors, nucleic acids-based testing, point-of-care tests, and galactomannans detection, in the diagnosis of mucormycosis, and thereby reinforces the need for further research on the topic.
format	article
author	Syed Mohammed Basheeruddin Asdaq Arya Rajan Aswin Damodaran Shivali R. Kamath Krishnanjana S. Nair Subin Mary Zachariah Ram Kumar Sahu Santosh Fattepur Nagaraja Sreeharsha Anroop Nair Shery Jacob Hussain A. Albahrani Eman H. Alkhaldi Yahya Mohzari Ahmed A. Alrashed Mohd. Imran
author_facet	Syed Mohammed Basheeruddin Asdaq Arya Rajan Aswin Damodaran Shivali R. Kamath Krishnanjana S. Nair Subin Mary Zachariah Ram Kumar Sahu Santosh Fattepur Nagaraja Sreeharsha Anroop Nair Shery Jacob Hussain A. Albahrani Eman H. Alkhaldi Yahya Mohzari Ahmed A. Alrashed Mohd. Imran
author_sort	Syed Mohammed Basheeruddin Asdaq
title	Identifying Mucormycosis Severity in Indian COVID-19 Patients: A Nano-Based Diagnosis and the Necessity for Critical Therapeutic Intervention
title_short	Identifying Mucormycosis Severity in Indian COVID-19 Patients: A Nano-Based Diagnosis and the Necessity for Critical Therapeutic Intervention
title_full	Identifying Mucormycosis Severity in Indian COVID-19 Patients: A Nano-Based Diagnosis and the Necessity for Critical Therapeutic Intervention
title_fullStr	Identifying Mucormycosis Severity in Indian COVID-19 Patients: A Nano-Based Diagnosis and the Necessity for Critical Therapeutic Intervention
title_full_unstemmed	Identifying Mucormycosis Severity in Indian COVID-19 Patients: A Nano-Based Diagnosis and the Necessity for Critical Therapeutic Intervention
title_sort	identifying mucormycosis severity in indian covid-19 patients: a nano-based diagnosis and the necessity for critical therapeutic intervention
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fdd41567703c452e88a45bbee7c93556
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Identifying Mucormycosis Severity in Indian COVID-19 Patients: A Nano-Based Diagnosis and the Necessity for Critical Therapeutic Intervention

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