Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite

The mechanisms of action of the antibacterial metalloid tellurite are unclear. Here, the authors show that tellurite induces an accumulation of hydroxyl radical and intermediates of heme biosynthesis inE. coli, and that the heme precursor 5-aminolevulinic acid potentiates tellurite toxicity.

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Autores principales:	Eduardo H. Morales, Camilo A. Pinto, Roberto Luraschi, Claudia M. Muñoz-Villagrán, Fabián A. Cornejo, Scott W. Simpkins, Justin Nelson, Felipe A. Arenas, Jeff S. Piotrowski, Chad L. Myers, Hirotada Mori, Claudio C. Vásquez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fdd5a80f0c384b64abef9129985eb409
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spelling	oai:doaj.org-article:fdd5a80f0c384b64abef9129985eb4092021-12-02T14:40:56ZAccumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite10.1038/ncomms153202041-1723https://doaj.org/article/fdd5a80f0c384b64abef9129985eb4092017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15320https://doaj.org/toc/2041-1723The mechanisms of action of the antibacterial metalloid tellurite are unclear. Here, the authors show that tellurite induces an accumulation of hydroxyl radical and intermediates of heme biosynthesis inE. coli, and that the heme precursor 5-aminolevulinic acid potentiates tellurite toxicity.Eduardo H. MoralesCamilo A. PintoRoberto LuraschiClaudia M. Muñoz-VillagránFabián A. CornejoScott W. SimpkinsJustin NelsonFelipe A. ArenasJeff S. PiotrowskiChad L. MyersHirotada MoriClaudio C. VásquezNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eduardo H. Morales Camilo A. Pinto Roberto Luraschi Claudia M. Muñoz-Villagrán Fabián A. Cornejo Scott W. Simpkins Justin Nelson Felipe A. Arenas Jeff S. Piotrowski Chad L. Myers Hirotada Mori Claudio C. Vásquez Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite
description	The mechanisms of action of the antibacterial metalloid tellurite are unclear. Here, the authors show that tellurite induces an accumulation of hydroxyl radical and intermediates of heme biosynthesis inE. coli, and that the heme precursor 5-aminolevulinic acid potentiates tellurite toxicity.
format	article
author	Eduardo H. Morales Camilo A. Pinto Roberto Luraschi Claudia M. Muñoz-Villagrán Fabián A. Cornejo Scott W. Simpkins Justin Nelson Felipe A. Arenas Jeff S. Piotrowski Chad L. Myers Hirotada Mori Claudio C. Vásquez
author_facet	Eduardo H. Morales Camilo A. Pinto Roberto Luraschi Claudia M. Muñoz-Villagrán Fabián A. Cornejo Scott W. Simpkins Justin Nelson Felipe A. Arenas Jeff S. Piotrowski Chad L. Myers Hirotada Mori Claudio C. Vásquez
author_sort	Eduardo H. Morales
title	Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite
title_short	Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite
title_full	Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite
title_fullStr	Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite
title_full_unstemmed	Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite
title_sort	accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fdd5a80f0c384b64abef9129985eb409
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Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite

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