Reduced frontal white matter microstructure in healthy older adults with low tactile recognition performance

Abstract The aging of the nervous system is a heterogeneous process. It remains a significant challenge to identify relevant markers of pathological and healthy brain aging. A central aspect of aging are decreased sensory acuities, especially because they correlate with the decline in higher cogniti...

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Autores principales:	Focko L. Higgen, Hanna Braaß, Winifried Backhaus, Robert Schulz, Gui Xue, Christian Gerloff
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fdd7271042d74716b59e0728b3a6f8e4
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spelling	oai:doaj.org-article:fdd7271042d74716b59e0728b3a6f8e42021-12-02T15:03:05ZReduced frontal white matter microstructure in healthy older adults with low tactile recognition performance10.1038/s41598-021-90995-w2045-2322https://doaj.org/article/fdd7271042d74716b59e0728b3a6f8e42021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90995-whttps://doaj.org/toc/2045-2322Abstract The aging of the nervous system is a heterogeneous process. It remains a significant challenge to identify relevant markers of pathological and healthy brain aging. A central aspect of aging are decreased sensory acuities, especially because they correlate with the decline in higher cognitive functioning. Sensory and higher cognitive processing relies on information flow between distant brain areas. Aging leads to disintegration of the underlying white matter tracts. While this disintegration is assumed to contribute to higher cognitive decline, data linking structural integrity and sensory function are sparse. The investigation of their interrelation may provide valuable insight into the mechanisms of brain aging. We used a combined behavioral and neuroimaging approach and investigated to what extent changes in microstructural white matter integrity reflect performance declines in tactile pattern recognition with aging. Poor performance in older participants was related to decreased integrity in the anterior corpus callosum. Probabilistic tractography showed that this structure is connected to the prefrontal cortices. Our data point to decreased integrity in the anterior corpus callosum as a marker for advanced brain aging. The correlation between impaired tactile recognition and disintegration in frontal brain networks could provide an explanation why the decrease of sensory function predicts cognitive decline.Focko L. HiggenHanna BraaßWinifried BackhausRobert SchulzGui XueChristian GerloffNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Focko L. Higgen Hanna Braaß Winifried Backhaus Robert Schulz Gui Xue Christian Gerloff Reduced frontal white matter microstructure in healthy older adults with low tactile recognition performance
description	Abstract The aging of the nervous system is a heterogeneous process. It remains a significant challenge to identify relevant markers of pathological and healthy brain aging. A central aspect of aging are decreased sensory acuities, especially because they correlate with the decline in higher cognitive functioning. Sensory and higher cognitive processing relies on information flow between distant brain areas. Aging leads to disintegration of the underlying white matter tracts. While this disintegration is assumed to contribute to higher cognitive decline, data linking structural integrity and sensory function are sparse. The investigation of their interrelation may provide valuable insight into the mechanisms of brain aging. We used a combined behavioral and neuroimaging approach and investigated to what extent changes in microstructural white matter integrity reflect performance declines in tactile pattern recognition with aging. Poor performance in older participants was related to decreased integrity in the anterior corpus callosum. Probabilistic tractography showed that this structure is connected to the prefrontal cortices. Our data point to decreased integrity in the anterior corpus callosum as a marker for advanced brain aging. The correlation between impaired tactile recognition and disintegration in frontal brain networks could provide an explanation why the decrease of sensory function predicts cognitive decline.
format	article
author	Focko L. Higgen Hanna Braaß Winifried Backhaus Robert Schulz Gui Xue Christian Gerloff
author_facet	Focko L. Higgen Hanna Braaß Winifried Backhaus Robert Schulz Gui Xue Christian Gerloff
author_sort	Focko L. Higgen
title	Reduced frontal white matter microstructure in healthy older adults with low tactile recognition performance
title_short	Reduced frontal white matter microstructure in healthy older adults with low tactile recognition performance
title_full	Reduced frontal white matter microstructure in healthy older adults with low tactile recognition performance
title_fullStr	Reduced frontal white matter microstructure in healthy older adults with low tactile recognition performance
title_full_unstemmed	Reduced frontal white matter microstructure in healthy older adults with low tactile recognition performance
title_sort	reduced frontal white matter microstructure in healthy older adults with low tactile recognition performance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fdd7271042d74716b59e0728b3a6f8e4
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_version_	1718389116067905536

Reduced frontal white matter microstructure in healthy older adults with low tactile recognition performance

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