Interplay of BAF and MLL4 promotes cell type-specific enhancer activation

The SWI/SNF complex BAF and the histone H3K4 methyltransferase MLL4 (KMT2D) play critical roles in enhancer activation, however the interplay between them has remained unclear. Here the authors show that BAF and MLL4 are interdependent in promoting enhancer activation by lineage-determining transcri...

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Autores principales:	Young-Kwon Park, Ji-Eun Lee, Zhijiang Yan, Kaitlin McKernan, Tommy O’Haren, Weidong Wang, Weiqun Peng, Kai Ge
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fdd9c8fc028c46c293e1d57053454796
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spelling	oai:doaj.org-article:fdd9c8fc028c46c293e1d570534547962021-12-02T13:31:14ZInterplay of BAF and MLL4 promotes cell type-specific enhancer activation10.1038/s41467-021-21893-y2041-1723https://doaj.org/article/fdd9c8fc028c46c293e1d570534547962021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21893-yhttps://doaj.org/toc/2041-1723The SWI/SNF complex BAF and the histone H3K4 methyltransferase MLL4 (KMT2D) play critical roles in enhancer activation, however the interplay between them has remained unclear. Here the authors show that BAF and MLL4 are interdependent in promoting enhancer activation by lineage-determining transcription factors during adipogenesis.Young-Kwon ParkJi-Eun LeeZhijiang YanKaitlin McKernanTommy O’HarenWeidong WangWeiqun PengKai GeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Young-Kwon Park Ji-Eun Lee Zhijiang Yan Kaitlin McKernan Tommy O’Haren Weidong Wang Weiqun Peng Kai Ge Interplay of BAF and MLL4 promotes cell type-specific enhancer activation
description	The SWI/SNF complex BAF and the histone H3K4 methyltransferase MLL4 (KMT2D) play critical roles in enhancer activation, however the interplay between them has remained unclear. Here the authors show that BAF and MLL4 are interdependent in promoting enhancer activation by lineage-determining transcription factors during adipogenesis.
format	article
author	Young-Kwon Park Ji-Eun Lee Zhijiang Yan Kaitlin McKernan Tommy O’Haren Weidong Wang Weiqun Peng Kai Ge
author_facet	Young-Kwon Park Ji-Eun Lee Zhijiang Yan Kaitlin McKernan Tommy O’Haren Weidong Wang Weiqun Peng Kai Ge
author_sort	Young-Kwon Park
title	Interplay of BAF and MLL4 promotes cell type-specific enhancer activation
title_short	Interplay of BAF and MLL4 promotes cell type-specific enhancer activation
title_full	Interplay of BAF and MLL4 promotes cell type-specific enhancer activation
title_fullStr	Interplay of BAF and MLL4 promotes cell type-specific enhancer activation
title_full_unstemmed	Interplay of BAF and MLL4 promotes cell type-specific enhancer activation
title_sort	interplay of baf and mll4 promotes cell type-specific enhancer activation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fdd9c8fc028c46c293e1d57053454796
work_keys_str_mv	AT youngkwonpark interplayofbafandmll4promotescelltypespecificenhanceractivation AT jieunlee interplayofbafandmll4promotescelltypespecificenhanceractivation AT zhijiangyan interplayofbafandmll4promotescelltypespecificenhanceractivation AT kaitlinmckernan interplayofbafandmll4promotescelltypespecificenhanceractivation AT tommyoharen interplayofbafandmll4promotescelltypespecificenhanceractivation AT weidongwang interplayofbafandmll4promotescelltypespecificenhanceractivation AT weiqunpeng interplayofbafandmll4promotescelltypespecificenhanceractivation AT kaige interplayofbafandmll4promotescelltypespecificenhanceractivation
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Interplay of BAF and MLL4 promotes cell type-specific enhancer activation

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