Interplay of BAF and MLL4 promotes cell type-specific enhancer activation

Interplay of BAF and MLL4 promotes cell type-specific enhancer activation

The SWI/SNF complex BAF and the histone H3K4 methyltransferase MLL4 (KMT2D) play critical roles in enhancer activation, however the interplay between them has remained unclear. Here the authors show that BAF and MLL4 are interdependent in promoting enhancer activation by lineage-determining transcri...

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Autores principales: Young-Kwon Park, Ji-Eun Lee, Zhijiang Yan, Kaitlin McKernan, Tommy O’Haren, Weidong Wang, Weiqun Peng, Kai Ge
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/fdd9c8fc028c46c293e1d57053454796
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