The ZNF76 rs10947540 polymorphism associated with systemic lupus erythematosus risk in Chinese populations

Abstract Systemic lupus erythematosus (SLE) is a typical autoimmune disease with a strong genetic disposition. Genetic studies have revealed that single-nucleotide polymorphisms (SNPs) in zinc finger protein (ZNF)-coding genes are associated with susceptibility to autoimmune diseases, including SLE....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yuan-yuan Qi, Yan Cui, Hui Lang, Ya-ling Zhai, Xiao-xue Zhang, Xiao-yang Wang, Xin-ran Liu, Ya-fei Zhao, Xiang-hui Ning, Zhan-zheng Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fddcaf2fee5b48428d41ac1fb5306e02
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fddcaf2fee5b48428d41ac1fb5306e02
record_format	dspace
spelling	oai:doaj.org-article:fddcaf2fee5b48428d41ac1fb5306e022021-12-02T11:37:27ZThe ZNF76 rs10947540 polymorphism associated with systemic lupus erythematosus risk in Chinese populations10.1038/s41598-021-84236-32045-2322https://doaj.org/article/fddcaf2fee5b48428d41ac1fb5306e022021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84236-3https://doaj.org/toc/2045-2322Abstract Systemic lupus erythematosus (SLE) is a typical autoimmune disease with a strong genetic disposition. Genetic studies have revealed that single-nucleotide polymorphisms (SNPs) in zinc finger protein (ZNF)-coding genes are associated with susceptibility to autoimmune diseases, including SLE. The objective of the current study was to evaluate the correlation between ZNF76 gene polymorphisms and SLE risk in Chinese populations. A total of 2801 individuals (1493 cases and 1308 controls) of Chinese Han origin were included in this two-stage genetic association study. The expression of ZNF76 was evaluated, and integrated bioinformatic analysis was also conducted. The results showed that 28 SNPs were associated with SLE susceptibility in the GWAS cohort, and the association of rs10947540 was successfully replicated in the independent replication cohort (P replication = 1.60 × 10−2, OR 1.19, 95% CI 1.03–1.37). After meta-analysis, the association between rs10947540 and SLE was pronounced (P meta = 9.62 × 10−6, OR 1.29, 95% CI 1.15–1.44). Stratified analysis suggested that ZNF76 rs10947540 C carriers were more likely to develop relatively high levels of serum creatinine (Scr) than noncarriers (CC + CT vs. TT, p = 9.94 × 10−4). The bioinformatic analysis revealed that ZNF76 rs10947540 was annotated as an eQTL and that rs10947540 was correlated with decreased expression of ZNF76. Remarkably, significantly reduced expression of ZNF76 was confirmed by expression data from both our laboratory and an array-based expression database. Taken together, these results suggest that ZNF76 rs10947540 is a possible susceptibility factor associated with SLE susceptibility. The mechanism underlying the relationship between ZNF76 and SLE pathogenesis still requires further investigation.Yuan-yuan QiYan CuiHui LangYa-ling ZhaiXiao-xue ZhangXiao-yang WangXin-ran LiuYa-fei ZhaoXiang-hui NingZhan-zheng ZhaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuan-yuan Qi Yan Cui Hui Lang Ya-ling Zhai Xiao-xue Zhang Xiao-yang Wang Xin-ran Liu Ya-fei Zhao Xiang-hui Ning Zhan-zheng Zhao The ZNF76 rs10947540 polymorphism associated with systemic lupus erythematosus risk in Chinese populations
description	Abstract Systemic lupus erythematosus (SLE) is a typical autoimmune disease with a strong genetic disposition. Genetic studies have revealed that single-nucleotide polymorphisms (SNPs) in zinc finger protein (ZNF)-coding genes are associated with susceptibility to autoimmune diseases, including SLE. The objective of the current study was to evaluate the correlation between ZNF76 gene polymorphisms and SLE risk in Chinese populations. A total of 2801 individuals (1493 cases and 1308 controls) of Chinese Han origin were included in this two-stage genetic association study. The expression of ZNF76 was evaluated, and integrated bioinformatic analysis was also conducted. The results showed that 28 SNPs were associated with SLE susceptibility in the GWAS cohort, and the association of rs10947540 was successfully replicated in the independent replication cohort (P replication = 1.60 × 10−2, OR 1.19, 95% CI 1.03–1.37). After meta-analysis, the association between rs10947540 and SLE was pronounced (P meta = 9.62 × 10−6, OR 1.29, 95% CI 1.15–1.44). Stratified analysis suggested that ZNF76 rs10947540 C carriers were more likely to develop relatively high levels of serum creatinine (Scr) than noncarriers (CC + CT vs. TT, p = 9.94 × 10−4). The bioinformatic analysis revealed that ZNF76 rs10947540 was annotated as an eQTL and that rs10947540 was correlated with decreased expression of ZNF76. Remarkably, significantly reduced expression of ZNF76 was confirmed by expression data from both our laboratory and an array-based expression database. Taken together, these results suggest that ZNF76 rs10947540 is a possible susceptibility factor associated with SLE susceptibility. The mechanism underlying the relationship between ZNF76 and SLE pathogenesis still requires further investigation.
format	article
author	Yuan-yuan Qi Yan Cui Hui Lang Ya-ling Zhai Xiao-xue Zhang Xiao-yang Wang Xin-ran Liu Ya-fei Zhao Xiang-hui Ning Zhan-zheng Zhao
author_facet	Yuan-yuan Qi Yan Cui Hui Lang Ya-ling Zhai Xiao-xue Zhang Xiao-yang Wang Xin-ran Liu Ya-fei Zhao Xiang-hui Ning Zhan-zheng Zhao
author_sort	Yuan-yuan Qi
title	The ZNF76 rs10947540 polymorphism associated with systemic lupus erythematosus risk in Chinese populations
title_short	The ZNF76 rs10947540 polymorphism associated with systemic lupus erythematosus risk in Chinese populations
title_full	The ZNF76 rs10947540 polymorphism associated with systemic lupus erythematosus risk in Chinese populations
title_fullStr	The ZNF76 rs10947540 polymorphism associated with systemic lupus erythematosus risk in Chinese populations
title_full_unstemmed	The ZNF76 rs10947540 polymorphism associated with systemic lupus erythematosus risk in Chinese populations
title_sort	znf76 rs10947540 polymorphism associated with systemic lupus erythematosus risk in chinese populations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fddcaf2fee5b48428d41ac1fb5306e02
work_keys_str_mv	AT yuanyuanqi theznf76rs10947540polymorphismassociatedwithsystemiclupuserythematosusriskinchinesepopulations AT yancui theznf76rs10947540polymorphismassociatedwithsystemiclupuserythematosusriskinchinesepopulations AT huilang theznf76rs10947540polymorphismassociatedwithsystemiclupuserythematosusriskinchinesepopulations AT yalingzhai theznf76rs10947540polymorphismassociatedwithsystemiclupuserythematosusriskinchinesepopulations AT xiaoxuezhang theznf76rs10947540polymorphismassociatedwithsystemiclupuserythematosusriskinchinesepopulations AT xiaoyangwang theznf76rs10947540polymorphismassociatedwithsystemiclupuserythematosusriskinchinesepopulations AT xinranliu theznf76rs10947540polymorphismassociatedwithsystemiclupuserythematosusriskinchinesepopulations AT yafeizhao theznf76rs10947540polymorphismassociatedwithsystemiclupuserythematosusriskinchinesepopulations AT xianghuining theznf76rs10947540polymorphismassociatedwithsystemiclupuserythematosusriskinchinesepopulations AT zhanzhengzhao theznf76rs10947540polymorphismassociatedwithsystemiclupuserythematosusriskinchinesepopulations AT yuanyuanqi znf76rs10947540polymorphismassociatedwithsystemiclupuserythematosusriskinchinesepopulations AT yancui znf76rs10947540polymorphismassociatedwithsystemiclupuserythematosusriskinchinesepopulations AT huilang znf76rs10947540polymorphismassociatedwithsystemiclupuserythematosusriskinchinesepopulations AT yalingzhai znf76rs10947540polymorphismassociatedwithsystemiclupuserythematosusriskinchinesepopulations AT xiaoxuezhang znf76rs10947540polymorphismassociatedwithsystemiclupuserythematosusriskinchinesepopulations AT xiaoyangwang znf76rs10947540polymorphismassociatedwithsystemiclupuserythematosusriskinchinesepopulations AT xinranliu znf76rs10947540polymorphismassociatedwithsystemiclupuserythematosusriskinchinesepopulations AT yafeizhao znf76rs10947540polymorphismassociatedwithsystemiclupuserythematosusriskinchinesepopulations AT xianghuining znf76rs10947540polymorphismassociatedwithsystemiclupuserythematosusriskinchinesepopulations AT zhanzhengzhao znf76rs10947540polymorphismassociatedwithsystemiclupuserythematosusriskinchinesepopulations
_version_	1718395799843373056

The ZNF76 rs10947540 polymorphism associated with systemic lupus erythematosus risk in Chinese populations

Ejemplares similares