Hiding in the dark: pan-cancer characterization of expression and clinical relevance of CD40 to immune checkpoint blockade therapy

Highlights CD40 expression correlates with the type I anti-tumor response and better survival. Pan-cancer bioinformatics characterization reveals reduced CD40 expression in 11 cancer types, including RAS mut melanoma compared to nevi. RAS mutation correlates with reduced CD40 expression in malignant...

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Autores principales:	Chi Yan, Ann Richmond
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	CD40 Cancer Nevi Melanoma PD-1/PD-L1 CTLA4 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/fdddad8feecb4eb2b7ceb5f48135d09a
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spelling	oai:doaj.org-article:fdddad8feecb4eb2b7ceb5f48135d09a2021-11-14T12:05:34ZHiding in the dark: pan-cancer characterization of expression and clinical relevance of CD40 to immune checkpoint blockade therapy10.1186/s12943-021-01442-31476-4598https://doaj.org/article/fdddad8feecb4eb2b7ceb5f48135d09a2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12943-021-01442-3https://doaj.org/toc/1476-4598Highlights CD40 expression correlates with the type I anti-tumor response and better survival. Pan-cancer bioinformatics characterization reveals reduced CD40 expression in 11 cancer types, including RAS mut melanoma compared to nevi. RAS mutation correlates with reduced CD40 expression in malignant melanoma. CD40 expression is associated with better response to immune checkpoint blockade therapy in melanoma.Chi YanAnn RichmondBMCarticleCD40CancerNeviMelanomaPD-1/PD-L1CTLA4Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENMolecular Cancer, Vol 20, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CD40 Cancer Nevi Melanoma PD-1/PD-L1 CTLA4 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	CD40 Cancer Nevi Melanoma PD-1/PD-L1 CTLA4 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Chi Yan Ann Richmond Hiding in the dark: pan-cancer characterization of expression and clinical relevance of CD40 to immune checkpoint blockade therapy
description	Highlights CD40 expression correlates with the type I anti-tumor response and better survival. Pan-cancer bioinformatics characterization reveals reduced CD40 expression in 11 cancer types, including RAS mut melanoma compared to nevi. RAS mutation correlates with reduced CD40 expression in malignant melanoma. CD40 expression is associated with better response to immune checkpoint blockade therapy in melanoma.
format	article
author	Chi Yan Ann Richmond
author_facet	Chi Yan Ann Richmond
author_sort	Chi Yan
title	Hiding in the dark: pan-cancer characterization of expression and clinical relevance of CD40 to immune checkpoint blockade therapy
title_short	Hiding in the dark: pan-cancer characterization of expression and clinical relevance of CD40 to immune checkpoint blockade therapy
title_full	Hiding in the dark: pan-cancer characterization of expression and clinical relevance of CD40 to immune checkpoint blockade therapy
title_fullStr	Hiding in the dark: pan-cancer characterization of expression and clinical relevance of CD40 to immune checkpoint blockade therapy
title_full_unstemmed	Hiding in the dark: pan-cancer characterization of expression and clinical relevance of CD40 to immune checkpoint blockade therapy
title_sort	hiding in the dark: pan-cancer characterization of expression and clinical relevance of cd40 to immune checkpoint blockade therapy
publisher	BMC
publishDate	2021
url	https://doaj.org/article/fdddad8feecb4eb2b7ceb5f48135d09a
work_keys_str_mv	AT chiyan hidinginthedarkpancancercharacterizationofexpressionandclinicalrelevanceofcd40toimmunecheckpointblockadetherapy AT annrichmond hidinginthedarkpancancercharacterizationofexpressionandclinicalrelevanceofcd40toimmunecheckpointblockadetherapy
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Hiding in the dark: pan-cancer characterization of expression and clinical relevance of CD40 to immune checkpoint blockade therapy

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