Low rate of pandemic A/H1N1 2009 influenza infection and lack of severe complication of vaccination in pregnant women: a prospective cohort study.
<h4>Background</h4>In 2009, pregnant women were specifically targeted by a national vaccination campaign against pandemic A/H1N1 influenza virus. The objectives of the COFLUPREG study, initially set up to assess the incidence of serious forms of A/H1N1 influenza, were to assess the conse...
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2012
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oai:doaj.org-article:fdddfbda2c614ebc8fcabd2c094a9c4a2021-11-18T08:03:31ZLow rate of pandemic A/H1N1 2009 influenza infection and lack of severe complication of vaccination in pregnant women: a prospective cohort study.1932-620310.1371/journal.pone.0052303https://doaj.org/article/fdddfbda2c614ebc8fcabd2c094a9c4a2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23300637/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>In 2009, pregnant women were specifically targeted by a national vaccination campaign against pandemic A/H1N1 influenza virus. The objectives of the COFLUPREG study, initially set up to assess the incidence of serious forms of A/H1N1 influenza, were to assess the consequences of maternal vaccination on pregnancy outcomes and maternal seroprotection at delivery.<h4>Methods</h4>Pregnant women, between 12 and 35 weeks of gestation, non vaccinated against A/H1N1 2009 influenza were randomly selected to be included in a prospective cohort study conducted in three maternity centers in Paris (France) during pandemic period. Blood samples were planned to assess hemagglutination inhibition (HI) antibody against A/H1N1 2009 influenza at inclusion and at delivery.<h4>Results</h4>Among the 877 pregnant women included in the study, 678 (77.3%) had serum samples both at inclusion and delivery, and 320 (36.5%) received pandemic A/H1N1 2009 influenza vaccine with a median interval between vaccination and delivery of 92 days (95% CI 48-134). At delivery, the proportion of women with seroprotection (HI antibodies titers against A/H1N1 2009 influenza of 1∶40 or greater) was 69.9% in vaccinated women. Of the 422 non-vaccinated women with serological data, 11 (2.6%; 95%CI: 1.3-4.6) had laboratory documented A/H1N1 2009 influenza (1 with positive PCR and 10 with serological seroconversion). None of the 877 study's women was hospitalized for flu. No difference on pregnancy outcomes was evidenced between vaccinated women, non-vaccinated women without seroconversion and non-vaccinated women with flu.<h4>Conclusion</h4>Despite low vaccine coverage, incidence of pandemic flu was low in this cohort of pregnant women.No effect on pregnancy and delivery outcomes was evidenced after vaccination.Odile LaunayAnne KrivineCaroline CharlierVan TrusterVassilis TsatsarisJacques LepercqYves VilleCarolyn AvenellThibaut AndrieuFlore RozenbergFlorence ArtiguebielleJean-Marc TréluyerFrançois GoffinetInserm COFLUPREG Study GroupPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e52303 (2012) |
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Medicine R Science Q Odile Launay Anne Krivine Caroline Charlier Van Truster Vassilis Tsatsaris Jacques Lepercq Yves Ville Carolyn Avenell Thibaut Andrieu Flore Rozenberg Florence Artiguebielle Jean-Marc Tréluyer François Goffinet Inserm COFLUPREG Study Group Low rate of pandemic A/H1N1 2009 influenza infection and lack of severe complication of vaccination in pregnant women: a prospective cohort study. |
| description |
<h4>Background</h4>In 2009, pregnant women were specifically targeted by a national vaccination campaign against pandemic A/H1N1 influenza virus. The objectives of the COFLUPREG study, initially set up to assess the incidence of serious forms of A/H1N1 influenza, were to assess the consequences of maternal vaccination on pregnancy outcomes and maternal seroprotection at delivery.<h4>Methods</h4>Pregnant women, between 12 and 35 weeks of gestation, non vaccinated against A/H1N1 2009 influenza were randomly selected to be included in a prospective cohort study conducted in three maternity centers in Paris (France) during pandemic period. Blood samples were planned to assess hemagglutination inhibition (HI) antibody against A/H1N1 2009 influenza at inclusion and at delivery.<h4>Results</h4>Among the 877 pregnant women included in the study, 678 (77.3%) had serum samples both at inclusion and delivery, and 320 (36.5%) received pandemic A/H1N1 2009 influenza vaccine with a median interval between vaccination and delivery of 92 days (95% CI 48-134). At delivery, the proportion of women with seroprotection (HI antibodies titers against A/H1N1 2009 influenza of 1∶40 or greater) was 69.9% in vaccinated women. Of the 422 non-vaccinated women with serological data, 11 (2.6%; 95%CI: 1.3-4.6) had laboratory documented A/H1N1 2009 influenza (1 with positive PCR and 10 with serological seroconversion). None of the 877 study's women was hospitalized for flu. No difference on pregnancy outcomes was evidenced between vaccinated women, non-vaccinated women without seroconversion and non-vaccinated women with flu.<h4>Conclusion</h4>Despite low vaccine coverage, incidence of pandemic flu was low in this cohort of pregnant women.No effect on pregnancy and delivery outcomes was evidenced after vaccination. |
| format |
article |
| author |
Odile Launay Anne Krivine Caroline Charlier Van Truster Vassilis Tsatsaris Jacques Lepercq Yves Ville Carolyn Avenell Thibaut Andrieu Flore Rozenberg Florence Artiguebielle Jean-Marc Tréluyer François Goffinet Inserm COFLUPREG Study Group |
| author_facet |
Odile Launay Anne Krivine Caroline Charlier Van Truster Vassilis Tsatsaris Jacques Lepercq Yves Ville Carolyn Avenell Thibaut Andrieu Flore Rozenberg Florence Artiguebielle Jean-Marc Tréluyer François Goffinet Inserm COFLUPREG Study Group |
| author_sort |
Odile Launay |
| title |
Low rate of pandemic A/H1N1 2009 influenza infection and lack of severe complication of vaccination in pregnant women: a prospective cohort study. |
| title_short |
Low rate of pandemic A/H1N1 2009 influenza infection and lack of severe complication of vaccination in pregnant women: a prospective cohort study. |
| title_full |
Low rate of pandemic A/H1N1 2009 influenza infection and lack of severe complication of vaccination in pregnant women: a prospective cohort study. |
| title_fullStr |
Low rate of pandemic A/H1N1 2009 influenza infection and lack of severe complication of vaccination in pregnant women: a prospective cohort study. |
| title_full_unstemmed |
Low rate of pandemic A/H1N1 2009 influenza infection and lack of severe complication of vaccination in pregnant women: a prospective cohort study. |
| title_sort |
low rate of pandemic a/h1n1 2009 influenza infection and lack of severe complication of vaccination in pregnant women: a prospective cohort study. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/fdddfbda2c614ebc8fcabd2c094a9c4a |
| work_keys_str_mv |
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