C-reactive protein is associated with severity of thought and language dysfunction in patients with schizophrenia

Chun-Hung Chang,1–3 Hsien-Yuan Lane,1,2,4,5,* Chieh-Yu Liu,6 Po-Chih Cheng,6 Shaw-Ji Chen,7,8 Chieh-Hsin Lin1,4,9,* 1Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan; 2Department of Psychiatry & Brain Disease Research Center, China Medical Universit...

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Autores principales:	Chang CH, Lane HY, Liu CY, Cheng PC, Chen SJ, Lin CH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	C-reactive protein formal thought disorder schizophrenia. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/fde2355beecd4bef875d552849f60508
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spelling	oai:doaj.org-article:fde2355beecd4bef875d552849f605082021-12-02T09:17:22ZC-reactive protein is associated with severity of thought and language dysfunction in patients with schizophrenia1178-2021https://doaj.org/article/fde2355beecd4bef875d552849f605082019-09-01T00:00:00Zhttps://www.dovepress.com/c-reactive-protein-is-associated-with-severity-of-thought-and-language-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Chun-Hung Chang,1–3 Hsien-Yuan Lane,1,2,4,5,* Chieh-Yu Liu,6 Po-Chih Cheng,6 Shaw-Ji Chen,7,8 Chieh-Hsin Lin1,4,9,* 1Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan; 2Department of Psychiatry & Brain Disease Research Center, China Medical University Hospital, Taichung, Taiwan; 3An Nan Hospital, China Medical University, Tainan, Taiwan; 4Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; 5Department of Psychology, College of Medical and Health Sciences, Asia University, Taichung, Taiwan; 6Biostatistical Consulting Laboratory, Department of Speech Language Pathology and Audiology, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan; 7Department of Psychiatry, Mackay Memorial Hospital Taitung Branch, Taitung, Taiwan; 8Department of Medicine, Mackay Medical College, New Taipei, Taiwan; 9Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan*These authors contributed equally to this workCorrespondence: Hsien-Yuan LaneDepartment of Psychiatry, China Medical University Hospital, No. 2, Yuh-Der Road, Taichung 404, TaiwanEmail hylane@gmail.com Chieh-Hsin LinDepartment of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, No 123, Dapi Road, Niaosong District, Kaohsiung 833, TaiwanTel +886 7 731 7123 Ext 8753Fax +886 7 732 6817Email cyndi36@gmail.comBackground: Numerous studies have demonstrated an association between C-reactive protein (CRP) levels and schizophrenia. However, the findings on psychotic severity and cognition remain inconsistent. The relationship between CRP and formal thought disorder in subdomains remains unclear.Methods: We enrolled stable patients (defined as those who had no treatment changes during the 4-week period before evaluation) with a diagnosis of schizophrenia or schizoaffective disorder, according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. We used the 30-item Thought and Language Disorder (TALD) scale to evaluate thought and language dysfunction over four subscales. We assessed psychotic symptoms using the Positive and Negative Syndrome Scale (PANSS). We collected fasting venous blood and measured plasma CRP levels.Results: We enrolled 60 patients with schizophrenia. All patients received TALD and PANSS evaluation, and 33 of them had their CRP levels checked. The multivariate regression analysis indicated that CRP levels were significantly associated with the total score on the TALD (t=2.757, P=0.010) and the TALD Objective Positive subscale (t=2.749, P=0.011), after sex, age, duration of illness (in years), and use of atypical antipsychotics were adjusted for. Additionally, CRP was significantly associated with the PANSS positive subscale (t=2.102, P=0.045). A significantly positive correlation was observed between the total scores on the TALD scale and PANSS (ρ =0.751, P<0.001).Conclusion: Our results suggest that abnormal CRP levels are significantly associated with formal thought and language dysfunction in the Objective Positive subdomain and positive psychotic symptoms.Keywords: C-reactive protein, formal thought disorder, schizophreniaChang CHLane HYLiu CYCheng PCChen SJLin CHDove Medical PressarticleC-reactive proteinformal thought disorderschizophrenia.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 2621-2627 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	C-reactive protein formal thought disorder schizophrenia. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	C-reactive protein formal thought disorder schizophrenia. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Chang CH Lane HY Liu CY Cheng PC Chen SJ Lin CH C-reactive protein is associated with severity of thought and language dysfunction in patients with schizophrenia
description	Chun-Hung Chang,1–3 Hsien-Yuan Lane,1,2,4,5,* Chieh-Yu Liu,6 Po-Chih Cheng,6 Shaw-Ji Chen,7,8 Chieh-Hsin Lin1,4,9,* 1Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan; 2Department of Psychiatry & Brain Disease Research Center, China Medical University Hospital, Taichung, Taiwan; 3An Nan Hospital, China Medical University, Tainan, Taiwan; 4Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; 5Department of Psychology, College of Medical and Health Sciences, Asia University, Taichung, Taiwan; 6Biostatistical Consulting Laboratory, Department of Speech Language Pathology and Audiology, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan; 7Department of Psychiatry, Mackay Memorial Hospital Taitung Branch, Taitung, Taiwan; 8Department of Medicine, Mackay Medical College, New Taipei, Taiwan; 9Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan*These authors contributed equally to this workCorrespondence: Hsien-Yuan LaneDepartment of Psychiatry, China Medical University Hospital, No. 2, Yuh-Der Road, Taichung 404, TaiwanEmail hylane@gmail.com Chieh-Hsin LinDepartment of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, No 123, Dapi Road, Niaosong District, Kaohsiung 833, TaiwanTel +886 7 731 7123 Ext 8753Fax +886 7 732 6817Email cyndi36@gmail.comBackground: Numerous studies have demonstrated an association between C-reactive protein (CRP) levels and schizophrenia. However, the findings on psychotic severity and cognition remain inconsistent. The relationship between CRP and formal thought disorder in subdomains remains unclear.Methods: We enrolled stable patients (defined as those who had no treatment changes during the 4-week period before evaluation) with a diagnosis of schizophrenia or schizoaffective disorder, according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. We used the 30-item Thought and Language Disorder (TALD) scale to evaluate thought and language dysfunction over four subscales. We assessed psychotic symptoms using the Positive and Negative Syndrome Scale (PANSS). We collected fasting venous blood and measured plasma CRP levels.Results: We enrolled 60 patients with schizophrenia. All patients received TALD and PANSS evaluation, and 33 of them had their CRP levels checked. The multivariate regression analysis indicated that CRP levels were significantly associated with the total score on the TALD (t=2.757, P=0.010) and the TALD Objective Positive subscale (t=2.749, P=0.011), after sex, age, duration of illness (in years), and use of atypical antipsychotics were adjusted for. Additionally, CRP was significantly associated with the PANSS positive subscale (t=2.102, P=0.045). A significantly positive correlation was observed between the total scores on the TALD scale and PANSS (ρ =0.751, P<0.001).Conclusion: Our results suggest that abnormal CRP levels are significantly associated with formal thought and language dysfunction in the Objective Positive subdomain and positive psychotic symptoms.Keywords: C-reactive protein, formal thought disorder, schizophrenia
format	article
author	Chang CH Lane HY Liu CY Cheng PC Chen SJ Lin CH
author_facet	Chang CH Lane HY Liu CY Cheng PC Chen SJ Lin CH
author_sort	Chang CH
title	C-reactive protein is associated with severity of thought and language dysfunction in patients with schizophrenia
title_short	C-reactive protein is associated with severity of thought and language dysfunction in patients with schizophrenia
title_full	C-reactive protein is associated with severity of thought and language dysfunction in patients with schizophrenia
title_fullStr	C-reactive protein is associated with severity of thought and language dysfunction in patients with schizophrenia
title_full_unstemmed	C-reactive protein is associated with severity of thought and language dysfunction in patients with schizophrenia
title_sort	c-reactive protein is associated with severity of thought and language dysfunction in patients with schizophrenia
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/fde2355beecd4bef875d552849f60508
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_version_	1718398221000114176

C-reactive protein is associated with severity of thought and language dysfunction in patients with schizophrenia

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