Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture of Scutellariae baicalensis radix Extract and Chitosan for Periodontal Diseases Treatment

Scutellaria baicalensis root displays anti-inflammatory and antibacterial properties due to the presence of flavonoids, particularly baicalin, baicalein, and wogonin. Our work aimed at developing thermosensitive hydrogels containing a binary mixture of S. baicalensis radi...

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Autores principales:	Justyna Chanaj-Kaczmarek, Tomasz Osmałek, Emilia Szymańska, Katarzyna Winnicka, Tomasz M. Karpiński, Magdalena Dyba, Marta Bekalarska-Dębek, Judyta Cielecka-Piontek
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Scutellaria baicalensis</i> chitosan periodontal diseases dissolution studies ex vivo mucoadhesion permeability Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/fde379b9134a4a56ad49a15f89a3de3d
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spelling	oai:doaj.org-article:fde379b9134a4a56ad49a15f89a3de3d2021-11-11T16:48:22ZDevelopment and Evaluation of Thermosensitive Hydrogels with Binary Mixture of <i>Scutellariae baicalensis radix</i> Extract and Chitosan for Periodontal Diseases Treatment10.3390/ijms2221113191422-00671661-6596https://doaj.org/article/fde379b9134a4a56ad49a15f89a3de3d2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11319https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067<i>Scutellaria baicalensis</i> root displays anti-inflammatory and antibacterial properties due to the presence of flavonoids, particularly baicalin, baicalein, and wogonin. Our work aimed at developing thermosensitive hydrogels containing a binary mixture of <i>S. baicalensis radix</i> lyophilized extract and chitosan as a novel approach for periodontal diseases treatment. Two types of chitosan were employed in preliminary studies on binary mixtures with <i>S. baicalensis radix</i> lyophilized extract standardized for baicalin, baicalein, and wogonin. Thermosensitive hydrogels were prepared of poloxamer 407, alginate sodium, and cellulose derivatives and evaluated in terms of rheological and mucoadhesive behavior. The presence of chitosan altered the release profile of active compounds but did not affect their in vitro permeation behavior in PAMPA assay. The synergistic effects of <i>S. baicalensis radix</i> lyophilized extract and chitosan toward ferrous ion-chelating activity, inhibition of hyaluronidase, and pathogen growth were observed. The thermosensitive gelling system showed shear-thinning properties, gelation temperature between 25 and 27 °C, and favorable mucoadhesiveness in contact with porcine buccal mucosa, which was enhanced in the presence of binary mixture of <i>S. baicalensis radix</i> extract and chitosan. The release tests showed that baicalin and baicalein were liberated in a prolonged manner with a fast onset from hydrogel formulations.Justyna Chanaj-KaczmarekTomasz OsmałekEmilia SzymańskaKatarzyna WinnickaTomasz M. KarpińskiMagdalena DybaMarta Bekalarska-DębekJudyta Cielecka-PiontekMDPI AGarticle<i>Scutellaria baicalensis</i>chitosanperiodontal diseasesdissolution studiesex vivo mucoadhesionpermeabilityBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11319, p 11319 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Scutellaria baicalensis</i> chitosan periodontal diseases dissolution studies ex vivo mucoadhesion permeability Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	<i>Scutellaria baicalensis</i> chitosan periodontal diseases dissolution studies ex vivo mucoadhesion permeability Biology (General) QH301-705.5 Chemistry QD1-999 Justyna Chanaj-Kaczmarek Tomasz Osmałek Emilia Szymańska Katarzyna Winnicka Tomasz M. Karpiński Magdalena Dyba Marta Bekalarska-Dębek Judyta Cielecka-Piontek Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture of <i>Scutellariae baicalensis radix</i> Extract and Chitosan for Periodontal Diseases Treatment
description	<i>Scutellaria baicalensis</i> root displays anti-inflammatory and antibacterial properties due to the presence of flavonoids, particularly baicalin, baicalein, and wogonin. Our work aimed at developing thermosensitive hydrogels containing a binary mixture of <i>S. baicalensis radix</i> lyophilized extract and chitosan as a novel approach for periodontal diseases treatment. Two types of chitosan were employed in preliminary studies on binary mixtures with <i>S. baicalensis radix</i> lyophilized extract standardized for baicalin, baicalein, and wogonin. Thermosensitive hydrogels were prepared of poloxamer 407, alginate sodium, and cellulose derivatives and evaluated in terms of rheological and mucoadhesive behavior. The presence of chitosan altered the release profile of active compounds but did not affect their in vitro permeation behavior in PAMPA assay. The synergistic effects of <i>S. baicalensis radix</i> lyophilized extract and chitosan toward ferrous ion-chelating activity, inhibition of hyaluronidase, and pathogen growth were observed. The thermosensitive gelling system showed shear-thinning properties, gelation temperature between 25 and 27 °C, and favorable mucoadhesiveness in contact with porcine buccal mucosa, which was enhanced in the presence of binary mixture of <i>S. baicalensis radix</i> extract and chitosan. The release tests showed that baicalin and baicalein were liberated in a prolonged manner with a fast onset from hydrogel formulations.
format	article
author	Justyna Chanaj-Kaczmarek Tomasz Osmałek Emilia Szymańska Katarzyna Winnicka Tomasz M. Karpiński Magdalena Dyba Marta Bekalarska-Dębek Judyta Cielecka-Piontek
author_facet	Justyna Chanaj-Kaczmarek Tomasz Osmałek Emilia Szymańska Katarzyna Winnicka Tomasz M. Karpiński Magdalena Dyba Marta Bekalarska-Dębek Judyta Cielecka-Piontek
author_sort	Justyna Chanaj-Kaczmarek
title	Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture of <i>Scutellariae baicalensis radix</i> Extract and Chitosan for Periodontal Diseases Treatment
title_short	Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture of <i>Scutellariae baicalensis radix</i> Extract and Chitosan for Periodontal Diseases Treatment
title_full	Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture of <i>Scutellariae baicalensis radix</i> Extract and Chitosan for Periodontal Diseases Treatment
title_fullStr	Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture of <i>Scutellariae baicalensis radix</i> Extract and Chitosan for Periodontal Diseases Treatment
title_full_unstemmed	Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture of <i>Scutellariae baicalensis radix</i> Extract and Chitosan for Periodontal Diseases Treatment
title_sort	development and evaluation of thermosensitive hydrogels with binary mixture of <i>scutellariae baicalensis radix</i> extract and chitosan for periodontal diseases treatment
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fde379b9134a4a56ad49a15f89a3de3d
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Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture of <i>Scutellariae baicalensis radix</i> Extract and Chitosan for Periodontal Diseases Treatment

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