Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5

Pdr5 is an ABC transporter conferring multidrug resistance to pathogenic fungi. Here, structural analysis of Pdr5 provides insights into the transport mechanism featuring asymmetric movements of Pdr5 domain and enabling efflux of a broad spectrum of compounds.

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Autores principales:	Andrzej Harris, Manuel Wagner, Dijun Du, Stefanie Raschka, Lea-Marie Nentwig, Holger Gohlke, Sander H. J. Smits, Ben F. Luisi, Lutz Schmitt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fde3b80a61364fc5a88b037e11881bf1
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spelling	oai:doaj.org-article:fde3b80a61364fc5a88b037e11881bf12021-12-02T14:55:15ZStructure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr510.1038/s41467-021-25574-82041-1723https://doaj.org/article/fde3b80a61364fc5a88b037e11881bf12021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25574-8https://doaj.org/toc/2041-1723Pdr5 is an ABC transporter conferring multidrug resistance to pathogenic fungi. Here, structural analysis of Pdr5 provides insights into the transport mechanism featuring asymmetric movements of Pdr5 domain and enabling efflux of a broad spectrum of compounds.Andrzej HarrisManuel WagnerDijun DuStefanie RaschkaLea-Marie NentwigHolger GohlkeSander H. J. SmitsBen F. LuisiLutz SchmittNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrzej Harris Manuel Wagner Dijun Du Stefanie Raschka Lea-Marie Nentwig Holger Gohlke Sander H. J. Smits Ben F. Luisi Lutz Schmitt Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5
description	Pdr5 is an ABC transporter conferring multidrug resistance to pathogenic fungi. Here, structural analysis of Pdr5 provides insights into the transport mechanism featuring asymmetric movements of Pdr5 domain and enabling efflux of a broad spectrum of compounds.
format	article
author	Andrzej Harris Manuel Wagner Dijun Du Stefanie Raschka Lea-Marie Nentwig Holger Gohlke Sander H. J. Smits Ben F. Luisi Lutz Schmitt
author_facet	Andrzej Harris Manuel Wagner Dijun Du Stefanie Raschka Lea-Marie Nentwig Holger Gohlke Sander H. J. Smits Ben F. Luisi Lutz Schmitt
author_sort	Andrzej Harris
title	Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5
title_short	Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5
title_full	Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5
title_fullStr	Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5
title_full_unstemmed	Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5
title_sort	structure and efflux mechanism of the yeast pleiotropic drug resistance transporter pdr5
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fde3b80a61364fc5a88b037e11881bf1
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Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5

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