C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression

C9orf72 repeat expansion is the major genetic cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here, the authors show that transcriptome aberrations commonly found in c9ALS/FTD are a result from defects in cellular RNA surveillance pathways that involve an RNA...

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Autores principales:	Yu Sun, Aziz Eshov, Jeffrey Zhou, Atagun U. Isiktas, Junjie U. Guo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fde5e583c03147f8b5baecedca93bb1a
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spelling	oai:doaj.org-article:fde5e583c03147f8b5baecedca93bb1a2021-12-02T18:18:53ZC9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression10.1038/s41467-020-17129-02041-1723https://doaj.org/article/fde5e583c03147f8b5baecedca93bb1a2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17129-0https://doaj.org/toc/2041-1723C9orf72 repeat expansion is the major genetic cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here, the authors show that transcriptome aberrations commonly found in c9ALS/FTD are a result from defects in cellular RNA surveillance pathways that involve an RNA helicase UPF1.Yu SunAziz EshovJeffrey ZhouAtagun U. IsiktasJunjie U. GuoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu Sun Aziz Eshov Jeffrey Zhou Atagun U. Isiktas Junjie U. Guo C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression
description	C9orf72 repeat expansion is the major genetic cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here, the authors show that transcriptome aberrations commonly found in c9ALS/FTD are a result from defects in cellular RNA surveillance pathways that involve an RNA helicase UPF1.
format	article
author	Yu Sun Aziz Eshov Jeffrey Zhou Atagun U. Isiktas Junjie U. Guo
author_facet	Yu Sun Aziz Eshov Jeffrey Zhou Atagun U. Isiktas Junjie U. Guo
author_sort	Yu Sun
title	C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression
title_short	C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression
title_full	C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression
title_fullStr	C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression
title_full_unstemmed	C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression
title_sort	c9orf72 arginine-rich dipeptide repeats inhibit upf1-mediated rna decay via translational repression
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fde5e583c03147f8b5baecedca93bb1a
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C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression

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