Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα

The binding of the leukocyte integrin Mac1 to the platelet receptor GPIbα is important for the physiological response to tissue injury. Here the authors show that this interaction also regulates thrombosis, without influencing bleeding time, which may provide clues for the development of new anti-th...

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Autores principales:	Yunmei Wang, Huiyun Gao, Can Shi, Paul W. Erhardt, Alexander Pavlovsky, Dmitry A. Soloviev, Kamila Bledzka, Valentin Ustinov, Liang Zhu, Jun Qin, Adam D. Munday, Jose Lopez, Edward Plow, Daniel I. Simon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fde7eceb216348f28d8514ea1e616f3d
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spelling	oai:doaj.org-article:fde7eceb216348f28d8514ea1e616f3d2021-12-02T14:41:22ZLeukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα10.1038/ncomms155592041-1723https://doaj.org/article/fde7eceb216348f28d8514ea1e616f3d2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15559https://doaj.org/toc/2041-1723The binding of the leukocyte integrin Mac1 to the platelet receptor GPIbα is important for the physiological response to tissue injury. Here the authors show that this interaction also regulates thrombosis, without influencing bleeding time, which may provide clues for the development of new anti-thrombotic drugs.Yunmei WangHuiyun GaoCan ShiPaul W. ErhardtAlexander PavlovskyDmitry A. SolovievKamila BledzkaValentin UstinovLiang ZhuJun QinAdam D. MundayJose LopezEdward PlowDaniel I. SimonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yunmei Wang Huiyun Gao Can Shi Paul W. Erhardt Alexander Pavlovsky Dmitry A. Soloviev Kamila Bledzka Valentin Ustinov Liang Zhu Jun Qin Adam D. Munday Jose Lopez Edward Plow Daniel I. Simon Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα
description	The binding of the leukocyte integrin Mac1 to the platelet receptor GPIbα is important for the physiological response to tissue injury. Here the authors show that this interaction also regulates thrombosis, without influencing bleeding time, which may provide clues for the development of new anti-thrombotic drugs.
format	article
author	Yunmei Wang Huiyun Gao Can Shi Paul W. Erhardt Alexander Pavlovsky Dmitry A. Soloviev Kamila Bledzka Valentin Ustinov Liang Zhu Jun Qin Adam D. Munday Jose Lopez Edward Plow Daniel I. Simon
author_facet	Yunmei Wang Huiyun Gao Can Shi Paul W. Erhardt Alexander Pavlovsky Dmitry A. Soloviev Kamila Bledzka Valentin Ustinov Liang Zhu Jun Qin Adam D. Munday Jose Lopez Edward Plow Daniel I. Simon
author_sort	Yunmei Wang
title	Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα
title_short	Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα
title_full	Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα
title_fullStr	Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα
title_full_unstemmed	Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα
title_sort	leukocyte integrin mac-1 regulates thrombosis via interaction with platelet gpibα
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fde7eceb216348f28d8514ea1e616f3d
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Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα

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