Effect of Diagnostic and Treatment Delay on the Risk of Tuberculosis Transmission in Shenzhen, China: An Observational Cohort Study, 1993-2010.

<h4>Introduction</h4>To understand better the risk of tuberculosis transmission with increasing delay in tuberculosis treatment, we undertook a retrospective cohort study in Shenzhen, China.<h4>Methods</h4>All pulmonary tuberculosis cases in the Shenzhen tuberculosis surveill...

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Autores principales:	Shiming Cheng, Wei Chen, Yingzhou Yang, Ping Chu, Xiaoli Liu, Meigui Zhao, Weiguo Tan, Li Xu, Qingfang Wu, Hongyun Guan, Jinhong Liu, Haitao Liu, Ray Y Chen, Zhongwei Jia
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fde881140790464887f7394b96bf99bb
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spelling	oai:doaj.org-article:fde881140790464887f7394b96bf99bb2021-11-18T07:39:40ZEffect of Diagnostic and Treatment Delay on the Risk of Tuberculosis Transmission in Shenzhen, China: An Observational Cohort Study, 1993-2010.1932-620310.1371/journal.pone.0067516https://doaj.org/article/fde881140790464887f7394b96bf99bb2013-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0067516https://doaj.org/toc/1932-6203<h4>Introduction</h4>To understand better the risk of tuberculosis transmission with increasing delay in tuberculosis treatment, we undertook a retrospective cohort study in Shenzhen, China.<h4>Methods</h4>All pulmonary tuberculosis cases in the Shenzhen tuberculosis surveillance database from 1993-2010 were included. Sputum smear positivity and presence of pulmonary cavity were used as proxies for risk of tuberculosis transmission.<h4>Results</h4>Among 48,441pulmonary tuberculosis cases, 70% presented with symptoms of pulmonary TB, 62% were sputum smear positive, and 21% had a pulmonary cavity on chest x-ray. 95.3% of patients self-presented for evaluation of illness after a median 58 days of delay after symptoms began. The proportion presenting sputum smear positive (p<0.001) and with a pulmonary cavity (p<0.001) increased significantly with increasing duration of delay.<h4>Conclusions</h4>Delayed diagnosis and treatment of tuberculosis is associated with a significantly increased risk of pulmonary sputum smear positivity and pulmonary cavity. To decrease risk of transmission, treatment delay needs to be reduced further.Shiming ChengWei ChenYingzhou YangPing ChuXiaoli LiuMeigui ZhaoWeiguo TanLi XuQingfang WuHongyun GuanJinhong LiuHaitao LiuRay Y ChenZhongwei JiaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e67516 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shiming Cheng Wei Chen Yingzhou Yang Ping Chu Xiaoli Liu Meigui Zhao Weiguo Tan Li Xu Qingfang Wu Hongyun Guan Jinhong Liu Haitao Liu Ray Y Chen Zhongwei Jia Effect of Diagnostic and Treatment Delay on the Risk of Tuberculosis Transmission in Shenzhen, China: An Observational Cohort Study, 1993-2010.
description	<h4>Introduction</h4>To understand better the risk of tuberculosis transmission with increasing delay in tuberculosis treatment, we undertook a retrospective cohort study in Shenzhen, China.<h4>Methods</h4>All pulmonary tuberculosis cases in the Shenzhen tuberculosis surveillance database from 1993-2010 were included. Sputum smear positivity and presence of pulmonary cavity were used as proxies for risk of tuberculosis transmission.<h4>Results</h4>Among 48,441pulmonary tuberculosis cases, 70% presented with symptoms of pulmonary TB, 62% were sputum smear positive, and 21% had a pulmonary cavity on chest x-ray. 95.3% of patients self-presented for evaluation of illness after a median 58 days of delay after symptoms began. The proportion presenting sputum smear positive (p<0.001) and with a pulmonary cavity (p<0.001) increased significantly with increasing duration of delay.<h4>Conclusions</h4>Delayed diagnosis and treatment of tuberculosis is associated with a significantly increased risk of pulmonary sputum smear positivity and pulmonary cavity. To decrease risk of transmission, treatment delay needs to be reduced further.
format	article
author	Shiming Cheng Wei Chen Yingzhou Yang Ping Chu Xiaoli Liu Meigui Zhao Weiguo Tan Li Xu Qingfang Wu Hongyun Guan Jinhong Liu Haitao Liu Ray Y Chen Zhongwei Jia
author_facet	Shiming Cheng Wei Chen Yingzhou Yang Ping Chu Xiaoli Liu Meigui Zhao Weiguo Tan Li Xu Qingfang Wu Hongyun Guan Jinhong Liu Haitao Liu Ray Y Chen Zhongwei Jia
author_sort	Shiming Cheng
title	Effect of Diagnostic and Treatment Delay on the Risk of Tuberculosis Transmission in Shenzhen, China: An Observational Cohort Study, 1993-2010.
title_short	Effect of Diagnostic and Treatment Delay on the Risk of Tuberculosis Transmission in Shenzhen, China: An Observational Cohort Study, 1993-2010.
title_full	Effect of Diagnostic and Treatment Delay on the Risk of Tuberculosis Transmission in Shenzhen, China: An Observational Cohort Study, 1993-2010.
title_fullStr	Effect of Diagnostic and Treatment Delay on the Risk of Tuberculosis Transmission in Shenzhen, China: An Observational Cohort Study, 1993-2010.
title_full_unstemmed	Effect of Diagnostic and Treatment Delay on the Risk of Tuberculosis Transmission in Shenzhen, China: An Observational Cohort Study, 1993-2010.
title_sort	effect of diagnostic and treatment delay on the risk of tuberculosis transmission in shenzhen, china: an observational cohort study, 1993-2010.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/fde881140790464887f7394b96bf99bb
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Effect of Diagnostic and Treatment Delay on the Risk of Tuberculosis Transmission in Shenzhen, China: An Observational Cohort Study, 1993-2010.

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