Following replicative DNA synthesis by time-resolved X-ray crystallography

DNA polymerases are the key enzymes responsible for DNA replication and repair. Here the authors reveal through time-lapsed images of X-ray crystal structures that translocation precedes phosphodiester bond formation in the mechanism of DNA synthesis.

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Autores principales:	Nicholas Chim, Roman A. Meza, Anh M. Trinh, Kefan Yang, John C. Chaput
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fdef6c3a75d9466da9d07b297cab93f2
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spelling	oai:doaj.org-article:fdef6c3a75d9466da9d07b297cab93f22021-12-02T15:36:28ZFollowing replicative DNA synthesis by time-resolved X-ray crystallography10.1038/s41467-021-22937-z2041-1723https://doaj.org/article/fdef6c3a75d9466da9d07b297cab93f22021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22937-zhttps://doaj.org/toc/2041-1723DNA polymerases are the key enzymes responsible for DNA replication and repair. Here the authors reveal through time-lapsed images of X-ray crystal structures that translocation precedes phosphodiester bond formation in the mechanism of DNA synthesis.Nicholas ChimRoman A. MezaAnh M. TrinhKefan YangJohn C. ChaputNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas Chim Roman A. Meza Anh M. Trinh Kefan Yang John C. Chaput Following replicative DNA synthesis by time-resolved X-ray crystallography
description	DNA polymerases are the key enzymes responsible for DNA replication and repair. Here the authors reveal through time-lapsed images of X-ray crystal structures that translocation precedes phosphodiester bond formation in the mechanism of DNA synthesis.
format	article
author	Nicholas Chim Roman A. Meza Anh M. Trinh Kefan Yang John C. Chaput
author_facet	Nicholas Chim Roman A. Meza Anh M. Trinh Kefan Yang John C. Chaput
author_sort	Nicholas Chim
title	Following replicative DNA synthesis by time-resolved X-ray crystallography
title_short	Following replicative DNA synthesis by time-resolved X-ray crystallography
title_full	Following replicative DNA synthesis by time-resolved X-ray crystallography
title_fullStr	Following replicative DNA synthesis by time-resolved X-ray crystallography
title_full_unstemmed	Following replicative DNA synthesis by time-resolved X-ray crystallography
title_sort	following replicative dna synthesis by time-resolved x-ray crystallography
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fdef6c3a75d9466da9d07b297cab93f2
work_keys_str_mv	AT nicholaschim followingreplicativednasynthesisbytimeresolvedxraycrystallography AT romanameza followingreplicativednasynthesisbytimeresolvedxraycrystallography AT anhmtrinh followingreplicativednasynthesisbytimeresolvedxraycrystallography AT kefanyang followingreplicativednasynthesisbytimeresolvedxraycrystallography AT johncchaput followingreplicativednasynthesisbytimeresolvedxraycrystallography
_version_	1718386331167490048

Following replicative DNA synthesis by time-resolved X-ray crystallography

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