Following replicative DNA synthesis by time-resolved X-ray crystallography

DNA polymerases are the key enzymes responsible for DNA replication and repair. Here the authors reveal through time-lapsed images of X-ray crystal structures that translocation precedes phosphodiester bond formation in the mechanism of DNA synthesis.

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Autores principales: Nicholas Chim, Roman A. Meza, Anh M. Trinh, Kefan Yang, John C. Chaput
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/fdef6c3a75d9466da9d07b297cab93f2
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