Structural basis for cofilin binding and actin filament disassembly

Cofilin is a small actin-binding protein that accelerates actin turnover by disassembling actin filaments. Here the authors present the 3.8 Å cryo-EM structure of a cofilin-decorated actin filament and discuss mechanistic implications.

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Autores principales:	Kotaro Tanaka, Shuichi Takeda, Kaoru Mitsuoka, Toshiro Oda, Chieko Kimura-Sakiyama, Yuichiro Maéda, Akihiro Narita
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fdefc781b9034aa19dc5ebb979aa6664
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spelling	oai:doaj.org-article:fdefc781b9034aa19dc5ebb979aa66642021-12-02T17:31:16ZStructural basis for cofilin binding and actin filament disassembly10.1038/s41467-018-04290-w2041-1723https://doaj.org/article/fdefc781b9034aa19dc5ebb979aa66642018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04290-whttps://doaj.org/toc/2041-1723Cofilin is a small actin-binding protein that accelerates actin turnover by disassembling actin filaments. Here the authors present the 3.8 Å cryo-EM structure of a cofilin-decorated actin filament and discuss mechanistic implications.Kotaro TanakaShuichi TakedaKaoru MitsuokaToshiro OdaChieko Kimura-SakiyamaYuichiro MaédaAkihiro NaritaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kotaro Tanaka Shuichi Takeda Kaoru Mitsuoka Toshiro Oda Chieko Kimura-Sakiyama Yuichiro Maéda Akihiro Narita Structural basis for cofilin binding and actin filament disassembly
description	Cofilin is a small actin-binding protein that accelerates actin turnover by disassembling actin filaments. Here the authors present the 3.8 Å cryo-EM structure of a cofilin-decorated actin filament and discuss mechanistic implications.
format	article
author	Kotaro Tanaka Shuichi Takeda Kaoru Mitsuoka Toshiro Oda Chieko Kimura-Sakiyama Yuichiro Maéda Akihiro Narita
author_facet	Kotaro Tanaka Shuichi Takeda Kaoru Mitsuoka Toshiro Oda Chieko Kimura-Sakiyama Yuichiro Maéda Akihiro Narita
author_sort	Kotaro Tanaka
title	Structural basis for cofilin binding and actin filament disassembly
title_short	Structural basis for cofilin binding and actin filament disassembly
title_full	Structural basis for cofilin binding and actin filament disassembly
title_fullStr	Structural basis for cofilin binding and actin filament disassembly
title_full_unstemmed	Structural basis for cofilin binding and actin filament disassembly
title_sort	structural basis for cofilin binding and actin filament disassembly
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fdefc781b9034aa19dc5ebb979aa6664
work_keys_str_mv	AT kotarotanaka structuralbasisforcofilinbindingandactinfilamentdisassembly AT shuichitakeda structuralbasisforcofilinbindingandactinfilamentdisassembly AT kaorumitsuoka structuralbasisforcofilinbindingandactinfilamentdisassembly AT toshirooda structuralbasisforcofilinbindingandactinfilamentdisassembly AT chiekokimurasakiyama structuralbasisforcofilinbindingandactinfilamentdisassembly AT yuichiromaeda structuralbasisforcofilinbindingandactinfilamentdisassembly AT akihironarita structuralbasisforcofilinbindingandactinfilamentdisassembly
_version_	1718380710917570560

Structural basis for cofilin binding and actin filament disassembly

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