Quantifying the binding landscapes of protein–protein interactions

Small changes in protein structure can have pronounced effects on protein–protein interactions, but quantifying this has only recently become possible. Now, the binding landscapes of three homologous enzyme–inhibitor complexes are quantified and shown to depend on whether the inhibitor binds its nat...

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Main Author:	Andrew J. Bissette
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Chemistry QD1-999
Online Access:	https://doaj.org/article/fdf098bc69d14825a9166967ea8fe1c4
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id	oai:doaj.org-article:fdf098bc69d14825a9166967ea8fe1c4
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spelling	oai:doaj.org-article:fdf098bc69d14825a9166967ea8fe1c42021-11-28T12:05:13ZQuantifying the binding landscapes of protein–protein interactions10.1038/s42004-021-00608-w2399-3669https://doaj.org/article/fdf098bc69d14825a9166967ea8fe1c42021-11-01T00:00:00Zhttps://doi.org/10.1038/s42004-021-00608-whttps://doaj.org/toc/2399-3669Small changes in protein structure can have pronounced effects on protein–protein interactions, but quantifying this has only recently become possible. Now, the binding landscapes of three homologous enzyme–inhibitor complexes are quantified and shown to depend on whether the inhibitor binds its natural target or a structurally similar protein.Andrew J. BissetteNature PortfolioarticleChemistryQD1-999ENCommunications Chemistry, Vol 4, Iss 1, Pp 1-2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemistry QD1-999
spellingShingle	Chemistry QD1-999 Andrew J. Bissette Quantifying the binding landscapes of protein–protein interactions
description	Small changes in protein structure can have pronounced effects on protein–protein interactions, but quantifying this has only recently become possible. Now, the binding landscapes of three homologous enzyme–inhibitor complexes are quantified and shown to depend on whether the inhibitor binds its natural target or a structurally similar protein.
format	article
author	Andrew J. Bissette
author_facet	Andrew J. Bissette
author_sort	Andrew J. Bissette
title	Quantifying the binding landscapes of protein–protein interactions
title_short	Quantifying the binding landscapes of protein–protein interactions
title_full	Quantifying the binding landscapes of protein–protein interactions
title_fullStr	Quantifying the binding landscapes of protein–protein interactions
title_full_unstemmed	Quantifying the binding landscapes of protein–protein interactions
title_sort	quantifying the binding landscapes of protein–protein interactions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fdf098bc69d14825a9166967ea8fe1c4
work_keys_str_mv	AT andrewjbissette quantifyingthebindinglandscapesofproteinproteininteractions
_version_	1718408236610093056

Quantifying the binding landscapes of protein–protein interactions

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