Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine

Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine

The tryptophan metabolite kynurenine is an endogenous ligand of the aryl hydrocarbon receptor (AHR). Here, the authors show that AHR targeting in IDO/TDO-expressing tumours counteracts a regulatory T cell/macrophage suppressive axis and synergizes with immune checkpoint blockade to hinder tumour gro...

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Main Authors: Luis Felipe Campesato, Sadna Budhu, Jeremy Tchaicha, Chien-Huan Weng, Mathieu Gigoux, Ivan Jose Cohen, David Redmond, Levi Mangarin, Stephane Pourpe, Cailian Liu, Roberta Zappasodi, Dmitriy Zamarin, Jill Cavanaugh, Alfredo C. Castro, Mark G. Manfredi, Karen McGovern, Taha Merghoub, Jedd D. Wolchok
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/fdf441e3eec44fe9aa3a5806a8a6b86b
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Summary:The tryptophan metabolite kynurenine is an endogenous ligand of the aryl hydrocarbon receptor (AHR). Here, the authors show that AHR targeting in IDO/TDO-expressing tumours counteracts a regulatory T cell/macrophage suppressive axis and synergizes with immune checkpoint blockade to hinder tumour growth.

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