Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine

The tryptophan metabolite kynurenine is an endogenous ligand of the aryl hydrocarbon receptor (AHR). Here, the authors show that AHR targeting in IDO/TDO-expressing tumours counteracts a regulatory T cell/macrophage suppressive axis and synergizes with immune checkpoint blockade to hinder tumour gro...

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Autores principales:	Luis Felipe Campesato, Sadna Budhu, Jeremy Tchaicha, Chien-Huan Weng, Mathieu Gigoux, Ivan Jose Cohen, David Redmond, Levi Mangarin, Stephane Pourpe, Cailian Liu, Roberta Zappasodi, Dmitriy Zamarin, Jill Cavanaugh, Alfredo C. Castro, Mark G. Manfredi, Karen McGovern, Taha Merghoub, Jedd D. Wolchok
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fdf441e3eec44fe9aa3a5806a8a6b86b
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spelling	oai:doaj.org-article:fdf441e3eec44fe9aa3a5806a8a6b86b2021-12-02T15:08:41ZBlockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine10.1038/s41467-020-17750-z2041-1723https://doaj.org/article/fdf441e3eec44fe9aa3a5806a8a6b86b2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17750-zhttps://doaj.org/toc/2041-1723The tryptophan metabolite kynurenine is an endogenous ligand of the aryl hydrocarbon receptor (AHR). Here, the authors show that AHR targeting in IDO/TDO-expressing tumours counteracts a regulatory T cell/macrophage suppressive axis and synergizes with immune checkpoint blockade to hinder tumour growth.Luis Felipe CampesatoSadna BudhuJeremy TchaichaChien-Huan WengMathieu GigouxIvan Jose CohenDavid RedmondLevi MangarinStephane PourpeCailian LiuRoberta ZappasodiDmitriy ZamarinJill CavanaughAlfredo C. CastroMark G. ManfrediKaren McGovernTaha MerghoubJedd D. WolchokNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luis Felipe Campesato Sadna Budhu Jeremy Tchaicha Chien-Huan Weng Mathieu Gigoux Ivan Jose Cohen David Redmond Levi Mangarin Stephane Pourpe Cailian Liu Roberta Zappasodi Dmitriy Zamarin Jill Cavanaugh Alfredo C. Castro Mark G. Manfredi Karen McGovern Taha Merghoub Jedd D. Wolchok Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine
description	The tryptophan metabolite kynurenine is an endogenous ligand of the aryl hydrocarbon receptor (AHR). Here, the authors show that AHR targeting in IDO/TDO-expressing tumours counteracts a regulatory T cell/macrophage suppressive axis and synergizes with immune checkpoint blockade to hinder tumour growth.
format	article
author	Luis Felipe Campesato Sadna Budhu Jeremy Tchaicha Chien-Huan Weng Mathieu Gigoux Ivan Jose Cohen David Redmond Levi Mangarin Stephane Pourpe Cailian Liu Roberta Zappasodi Dmitriy Zamarin Jill Cavanaugh Alfredo C. Castro Mark G. Manfredi Karen McGovern Taha Merghoub Jedd D. Wolchok
author_facet	Luis Felipe Campesato Sadna Budhu Jeremy Tchaicha Chien-Huan Weng Mathieu Gigoux Ivan Jose Cohen David Redmond Levi Mangarin Stephane Pourpe Cailian Liu Roberta Zappasodi Dmitriy Zamarin Jill Cavanaugh Alfredo C. Castro Mark G. Manfredi Karen McGovern Taha Merghoub Jedd D. Wolchok
author_sort	Luis Felipe Campesato
title	Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine
title_short	Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine
title_full	Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine
title_fullStr	Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine
title_full_unstemmed	Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine
title_sort	blockade of the ahr restricts a treg-macrophage suppressive axis induced by l-kynurenine
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fdf441e3eec44fe9aa3a5806a8a6b86b
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Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine

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