Second Primary Renal Cell Carcinoma With Nonrenal Malignancies: An Analysis of 118 Cases and a Review of Literature

ObjectivesTo evaluate the nature, diagnosis, treatment and prognosis of second primary renal cell carcinoma (SPRCC).Materials and MethodsWe retrospectively collected data from 118 patients with SPRCC. Clinical characteristics, imaging features and treatments were analyzed and comparisons between SPR...

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Autores principales:	Jinchao Chen, Nienie Qi, Hua Wang, Zongping Wang, Yedie He, Shaoxing Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	renal cell carcinoma multiple primary malignancy diagnosis treatment renal metastases Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/fdf83679149148ff82807d124f3c21b0
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spelling	oai:doaj.org-article:fdf83679149148ff82807d124f3c21b02021-12-01T01:28:43ZSecond Primary Renal Cell Carcinoma With Nonrenal Malignancies: An Analysis of 118 Cases and a Review of Literature2234-943X10.3389/fonc.2021.780130https://doaj.org/article/fdf83679149148ff82807d124f3c21b02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.780130/fullhttps://doaj.org/toc/2234-943XObjectivesTo evaluate the nature, diagnosis, treatment and prognosis of second primary renal cell carcinoma (SPRCC).Materials and MethodsWe retrospectively collected data from 118 patients with SPRCC. Clinical characteristics, imaging features and treatments were analyzed and comparisons between SPRCC and renal metastases (RM) were made.ResultsSPRCC accounts for 11.4% of all RCC. The most common types of extrarenal malignancies included lung, colorectal, breast and gynecological cancers. The median age was 58.5 years old, and 61.0% (72/118) of the patients were male. About 5.1% of the patients presented with symptoms. The average tumor diameter was 4.4 cm (1-8.4 cm). The diagnostic specificity of enhanced computed tomography (CT) was 80.1%. When comparing with RM, more patients with stage I–II extrarenal malignancy and less patients with bilateral, multiple, and endogenic renal masses on computed tomography were found in the SPRCC group. A total of 110 SPRCC patients underwent surgery, including 48 radical nephrectomies and 62 partial nephrectomies. The median overall survival time was 117 months. Female, asymptomatic status, no distant metastasis, and surgical treatment predicted a better survival.ConclusionsSPRCC are not uncommon, and it should be considered during the follow-up of patients with nonrenal malignancy. The differential diagnosis between SPRCC and RM was mainly based on imaging and puncture biopsy.Jinchao ChenNienie QiHua WangZongping WangYedie HeShaoxing ZhuFrontiers Media S.A.articlerenal cell carcinomamultiple primary malignancydiagnosistreatmentrenal metastasesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	renal cell carcinoma multiple primary malignancy diagnosis treatment renal metastases Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	renal cell carcinoma multiple primary malignancy diagnosis treatment renal metastases Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jinchao Chen Nienie Qi Hua Wang Zongping Wang Yedie He Shaoxing Zhu Second Primary Renal Cell Carcinoma With Nonrenal Malignancies: An Analysis of 118 Cases and a Review of Literature
description	ObjectivesTo evaluate the nature, diagnosis, treatment and prognosis of second primary renal cell carcinoma (SPRCC).Materials and MethodsWe retrospectively collected data from 118 patients with SPRCC. Clinical characteristics, imaging features and treatments were analyzed and comparisons between SPRCC and renal metastases (RM) were made.ResultsSPRCC accounts for 11.4% of all RCC. The most common types of extrarenal malignancies included lung, colorectal, breast and gynecological cancers. The median age was 58.5 years old, and 61.0% (72/118) of the patients were male. About 5.1% of the patients presented with symptoms. The average tumor diameter was 4.4 cm (1-8.4 cm). The diagnostic specificity of enhanced computed tomography (CT) was 80.1%. When comparing with RM, more patients with stage I–II extrarenal malignancy and less patients with bilateral, multiple, and endogenic renal masses on computed tomography were found in the SPRCC group. A total of 110 SPRCC patients underwent surgery, including 48 radical nephrectomies and 62 partial nephrectomies. The median overall survival time was 117 months. Female, asymptomatic status, no distant metastasis, and surgical treatment predicted a better survival.ConclusionsSPRCC are not uncommon, and it should be considered during the follow-up of patients with nonrenal malignancy. The differential diagnosis between SPRCC and RM was mainly based on imaging and puncture biopsy.
format	article
author	Jinchao Chen Nienie Qi Hua Wang Zongping Wang Yedie He Shaoxing Zhu
author_facet	Jinchao Chen Nienie Qi Hua Wang Zongping Wang Yedie He Shaoxing Zhu
author_sort	Jinchao Chen
title	Second Primary Renal Cell Carcinoma With Nonrenal Malignancies: An Analysis of 118 Cases and a Review of Literature
title_short	Second Primary Renal Cell Carcinoma With Nonrenal Malignancies: An Analysis of 118 Cases and a Review of Literature
title_full	Second Primary Renal Cell Carcinoma With Nonrenal Malignancies: An Analysis of 118 Cases and a Review of Literature
title_fullStr	Second Primary Renal Cell Carcinoma With Nonrenal Malignancies: An Analysis of 118 Cases and a Review of Literature
title_full_unstemmed	Second Primary Renal Cell Carcinoma With Nonrenal Malignancies: An Analysis of 118 Cases and a Review of Literature
title_sort	second primary renal cell carcinoma with nonrenal malignancies: an analysis of 118 cases and a review of literature
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/fdf83679149148ff82807d124f3c21b0
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Second Primary Renal Cell Carcinoma With Nonrenal Malignancies: An Analysis of 118 Cases and a Review of Literature

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