Effects of antioxidant supplementation on the aging process

Domenico Fusco1, Giuseppe Colloca1, Maria Rita Lo Monaco1, Matteo Cesari1,21Department of Gerontology, Geriatrics and Physiatry; Catholic University of Sacred Heart, Rome, Italy; 2Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville,...

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Autores principales:	Domenico Fusco, Giuseppe Colloca, Maria Rita Lo Monaco, Matteo Cesari
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2007
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/fdf977e2dfb6417fb4f98538e8fdead8
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spelling	oai:doaj.org-article:fdf977e2dfb6417fb4f98538e8fdead82021-12-02T08:13:52ZEffects of antioxidant supplementation on the aging process1178-1998https://doaj.org/article/fdf977e2dfb6417fb4f98538e8fdead82007-10-01T00:00:00Zhttps://www.dovepress.com/effects-of-antioxidant-supplementation-on-the-aging-process-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Domenico Fusco1, Giuseppe Colloca1, Maria Rita Lo Monaco1, Matteo Cesari1,21Department of Gerontology, Geriatrics and Physiatry; Catholic University of Sacred Heart, Rome, Italy; 2Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FLAbstract: The free radical theory of aging hypothesizes that oxygen-derived free radicals are responsible for the age-related damage at the cellular and tissue levels. In a normal situation, a balanced-equilibrium exists among oxidants, antioxidants and biomolecules. Excess generation of free radicals may overwhelm natural cellular antioxidant defences leading to oxidation and further contributing to cellular functional impairment. The identification of free radical reactions as promoters of the aging process implies that interventions aimed at limiting or inhibiting them should be able to reduce the rate of formation of aging changes with a consequent reduction of the aging rate and disease pathogenesis. Even if antioxidant supplementation is receiving growing attention and is increasingly adopted in Western countries, supporting evidence is still scarce and equivocal. Major limitations in literature are still needed to be addressed to better evaluate the potential benefits from antioxidant supplementation: 1) an improved understanding of oxidation mechanisms possibly at the basis of the aging process, 2) the determination of reliable markers of oxidative damage and antioxidant status, 3) the identification of a therapeutic window in which an eventual antioxidant supplementation may be beneficial, 4) a deeper knowledge of the antioxidant molecules which in several conditions act as pro-oxidants. In the present paper, after a preliminary introduction to the free radical theory of aging and the rationale of antioxidant supplementation as an anti-aging intervention, we will present an overview of evidence relating antioxidant supplementations with clinical conditions typical of older age (ie, cardiovascular disease, Alzheimer’s disease, cancer). We will also discuss studies that have evaluated whether antioxidant supplementation might improve major outcomes of interest in older persons (ie, physical performance, muscle strength, longevity). Given the large amount of data available on the antioxidant supplementation topic, this overview is not intended to be exhaustive. The aim of this paper is to provide the main basis from which future studies should start and indicate which the main limitations that need to be addressed are.Keywords: aging, anti-aging medicine, antioxidant supplementation, oxidative damageDomenico FuscoGiuseppe CollocaMaria Rita Lo MonacoMatteo CesariDove Medical PressarticleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 2, Pp 377-387 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Domenico Fusco Giuseppe Colloca Maria Rita Lo Monaco Matteo Cesari Effects of antioxidant supplementation on the aging process
description	Domenico Fusco1, Giuseppe Colloca1, Maria Rita Lo Monaco1, Matteo Cesari1,21Department of Gerontology, Geriatrics and Physiatry; Catholic University of Sacred Heart, Rome, Italy; 2Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FLAbstract: The free radical theory of aging hypothesizes that oxygen-derived free radicals are responsible for the age-related damage at the cellular and tissue levels. In a normal situation, a balanced-equilibrium exists among oxidants, antioxidants and biomolecules. Excess generation of free radicals may overwhelm natural cellular antioxidant defences leading to oxidation and further contributing to cellular functional impairment. The identification of free radical reactions as promoters of the aging process implies that interventions aimed at limiting or inhibiting them should be able to reduce the rate of formation of aging changes with a consequent reduction of the aging rate and disease pathogenesis. Even if antioxidant supplementation is receiving growing attention and is increasingly adopted in Western countries, supporting evidence is still scarce and equivocal. Major limitations in literature are still needed to be addressed to better evaluate the potential benefits from antioxidant supplementation: 1) an improved understanding of oxidation mechanisms possibly at the basis of the aging process, 2) the determination of reliable markers of oxidative damage and antioxidant status, 3) the identification of a therapeutic window in which an eventual antioxidant supplementation may be beneficial, 4) a deeper knowledge of the antioxidant molecules which in several conditions act as pro-oxidants. In the present paper, after a preliminary introduction to the free radical theory of aging and the rationale of antioxidant supplementation as an anti-aging intervention, we will present an overview of evidence relating antioxidant supplementations with clinical conditions typical of older age (ie, cardiovascular disease, Alzheimer’s disease, cancer). We will also discuss studies that have evaluated whether antioxidant supplementation might improve major outcomes of interest in older persons (ie, physical performance, muscle strength, longevity). Given the large amount of data available on the antioxidant supplementation topic, this overview is not intended to be exhaustive. The aim of this paper is to provide the main basis from which future studies should start and indicate which the main limitations that need to be addressed are.Keywords: aging, anti-aging medicine, antioxidant supplementation, oxidative damage
format	article
author	Domenico Fusco Giuseppe Colloca Maria Rita Lo Monaco Matteo Cesari
author_facet	Domenico Fusco Giuseppe Colloca Maria Rita Lo Monaco Matteo Cesari
author_sort	Domenico Fusco
title	Effects of antioxidant supplementation on the aging process
title_short	Effects of antioxidant supplementation on the aging process
title_full	Effects of antioxidant supplementation on the aging process
title_fullStr	Effects of antioxidant supplementation on the aging process
title_full_unstemmed	Effects of antioxidant supplementation on the aging process
title_sort	effects of antioxidant supplementation on the aging process
publisher	Dove Medical Press
publishDate	2007
url	https://doaj.org/article/fdf977e2dfb6417fb4f98538e8fdead8
work_keys_str_mv	AT domenicofusco effectsofantioxidantsupplementationontheagingprocess AT giuseppecolloca effectsofantioxidantsupplementationontheagingprocess AT mariaritalomonaco effectsofantioxidantsupplementationontheagingprocess AT matteocesari effectsofantioxidantsupplementationontheagingprocess
_version_	1718398641308172288

Effects of antioxidant supplementation on the aging process

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