Tuberculosis recurrence after completion treatment in a European city: reinfection or relapse?

<h4>Background</h4>Tuberculosis (TB) recurrence can be due to reinfection or relapse. The contribution of each to TB incidence and the factors associated with recurrence are not well known. Effectiveness of TB control programs is assessed in part by recurrence rates. The aim of this stud...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Juan-Pablo Millet, Evelyn Shaw, Angels Orcau, Martí Casals, Jose M Miró, Joan A Caylà, Barcelona Tuberculosis Recurrence Working Group
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fdfb1b9703e7433dab8706123498a0c7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fdfb1b9703e7433dab8706123498a0c7
record_format	dspace
spelling	oai:doaj.org-article:fdfb1b9703e7433dab8706123498a0c72021-11-18T07:42:24ZTuberculosis recurrence after completion treatment in a European city: reinfection or relapse?1932-620310.1371/journal.pone.0064898https://doaj.org/article/fdfb1b9703e7433dab8706123498a0c72013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23776440/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Tuberculosis (TB) recurrence can be due to reinfection or relapse. The contribution of each to TB incidence and the factors associated with recurrence are not well known. Effectiveness of TB control programs is assessed in part by recurrence rates. The aim of this study was to establish the recurrence rate of TB in Barcelona, the associated risk factors and the role of reinfection.<h4>Methods</h4>A population-based retrospective longitudinal study was performed in Barcelona, Spain. TB patients with positive culture results who completed treatment between Jan 1(st), 2003 and Dec 31(st), 2006 were followed-up until December 31st, 2009 by the TB Control Program. The incidence rate of recurrence was calculated per person-year of follow-up (py). Kaplan-Meier and Cox regression methods were used for the survival analysis by calculating the hazard ratio (HR) with 95% confidence intervals (CI).<h4>Results</h4>Of the 1,823 TB cases identified, 971 fulfilled the inclusion criteria and 13 (1.3%) had recurrent TB. The recurrence rate was 341 cases per 100,000 py, 13 times higher than the TB incidence of the general population. Likelihood of TB recurrence at the 1st, 3rd and 5th year of follow-up was 0.1%, 1.4% and 1.6%, respectively. Factors associated with recurrence were HIV infection (HR: 4.7, CI: 1.4-15.7), living in the inner city district (HR: 3.9, CI: 1.3-11.8) and history of TB treatment (HR: 5.2, CI: 1.7-16.2). Genotyping results of recurrent cases were available for 6 patients (3 reinfections and 3 relapses).<h4>Conclusion</h4>The rate of TB recurrence in Barcelona is low and most episodes occur within the first three years. Patients at higher risk of recurrence are co-infected with HIV, living in neighborhoods with high TB incidence or with a history of TB treatment. When available, genotyping results help determine whether the recurrence is due to reinfection or relapse.Juan-Pablo MilletEvelyn ShawAngels OrcauMartí CasalsJose M MiróJoan A CaylàBarcelona Tuberculosis Recurrence Working GroupPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e64898 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juan-Pablo Millet Evelyn Shaw Angels Orcau Martí Casals Jose M Miró Joan A Caylà Barcelona Tuberculosis Recurrence Working Group Tuberculosis recurrence after completion treatment in a European city: reinfection or relapse?
description	<h4>Background</h4>Tuberculosis (TB) recurrence can be due to reinfection or relapse. The contribution of each to TB incidence and the factors associated with recurrence are not well known. Effectiveness of TB control programs is assessed in part by recurrence rates. The aim of this study was to establish the recurrence rate of TB in Barcelona, the associated risk factors and the role of reinfection.<h4>Methods</h4>A population-based retrospective longitudinal study was performed in Barcelona, Spain. TB patients with positive culture results who completed treatment between Jan 1(st), 2003 and Dec 31(st), 2006 were followed-up until December 31st, 2009 by the TB Control Program. The incidence rate of recurrence was calculated per person-year of follow-up (py). Kaplan-Meier and Cox regression methods were used for the survival analysis by calculating the hazard ratio (HR) with 95% confidence intervals (CI).<h4>Results</h4>Of the 1,823 TB cases identified, 971 fulfilled the inclusion criteria and 13 (1.3%) had recurrent TB. The recurrence rate was 341 cases per 100,000 py, 13 times higher than the TB incidence of the general population. Likelihood of TB recurrence at the 1st, 3rd and 5th year of follow-up was 0.1%, 1.4% and 1.6%, respectively. Factors associated with recurrence were HIV infection (HR: 4.7, CI: 1.4-15.7), living in the inner city district (HR: 3.9, CI: 1.3-11.8) and history of TB treatment (HR: 5.2, CI: 1.7-16.2). Genotyping results of recurrent cases were available for 6 patients (3 reinfections and 3 relapses).<h4>Conclusion</h4>The rate of TB recurrence in Barcelona is low and most episodes occur within the first three years. Patients at higher risk of recurrence are co-infected with HIV, living in neighborhoods with high TB incidence or with a history of TB treatment. When available, genotyping results help determine whether the recurrence is due to reinfection or relapse.
format	article
author	Juan-Pablo Millet Evelyn Shaw Angels Orcau Martí Casals Jose M Miró Joan A Caylà Barcelona Tuberculosis Recurrence Working Group
author_facet	Juan-Pablo Millet Evelyn Shaw Angels Orcau Martí Casals Jose M Miró Joan A Caylà Barcelona Tuberculosis Recurrence Working Group
author_sort	Juan-Pablo Millet
title	Tuberculosis recurrence after completion treatment in a European city: reinfection or relapse?
title_short	Tuberculosis recurrence after completion treatment in a European city: reinfection or relapse?
title_full	Tuberculosis recurrence after completion treatment in a European city: reinfection or relapse?
title_fullStr	Tuberculosis recurrence after completion treatment in a European city: reinfection or relapse?
title_full_unstemmed	Tuberculosis recurrence after completion treatment in a European city: reinfection or relapse?
title_sort	tuberculosis recurrence after completion treatment in a european city: reinfection or relapse?
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/fdfb1b9703e7433dab8706123498a0c7
work_keys_str_mv	AT juanpablomillet tuberculosisrecurrenceaftercompletiontreatmentinaeuropeancityreinfectionorrelapse AT evelynshaw tuberculosisrecurrenceaftercompletiontreatmentinaeuropeancityreinfectionorrelapse AT angelsorcau tuberculosisrecurrenceaftercompletiontreatmentinaeuropeancityreinfectionorrelapse AT marticasals tuberculosisrecurrenceaftercompletiontreatmentinaeuropeancityreinfectionorrelapse AT josemmiro tuberculosisrecurrenceaftercompletiontreatmentinaeuropeancityreinfectionorrelapse AT joanacayla tuberculosisrecurrenceaftercompletiontreatmentinaeuropeancityreinfectionorrelapse AT barcelonatuberculosisrecurrenceworkinggroup tuberculosisrecurrenceaftercompletiontreatmentinaeuropeancityreinfectionorrelapse
_version_	1718423138287484928

Tuberculosis recurrence after completion treatment in a European city: reinfection or relapse?

Ejemplares similares