Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes
The molecular identity of renal glomerular cells is poorly characterized and rodent glomerulopathy models translate poorly to humans. Here, the authors show molecular signatures of glomerulus-associated cells using single cell RNA sequencing and highlight differences between mouse and human cells.
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Nature Portfolio
2021
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oai:doaj.org-article:fe04160ada134a20a0af7aef65e1f1062021-12-02T14:37:13ZSingle-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes10.1038/s41467-021-22331-92041-1723https://doaj.org/article/fe04160ada134a20a0af7aef65e1f1062021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22331-9https://doaj.org/toc/2041-1723The molecular identity of renal glomerular cells is poorly characterized and rodent glomerulopathy models translate poorly to humans. Here, the authors show molecular signatures of glomerulus-associated cells using single cell RNA sequencing and highlight differences between mouse and human cells.Bing HePing ChenSonia ZambranoDina DabaghieYizhou HuKatja Möller-HackbarthDavid Unnersjö-JessGül Gizem KorkutEmmanuelle CharrinMarie JeanssonMaria Bintanel-MorcilloAnna WitaspLars WennbergAnnika WernersonBernhard SchermerThomas BenzingPatrik ErnforsChrister BetsholtzMark LalRickard SandbergJaakko PatrakkaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021) |
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Science Q |
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Science Q Bing He Ping Chen Sonia Zambrano Dina Dabaghie Yizhou Hu Katja Möller-Hackbarth David Unnersjö-Jess Gül Gizem Korkut Emmanuelle Charrin Marie Jeansson Maria Bintanel-Morcillo Anna Witasp Lars Wennberg Annika Wernerson Bernhard Schermer Thomas Benzing Patrik Ernfors Christer Betsholtz Mark Lal Rickard Sandberg Jaakko Patrakka Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes |
description |
The molecular identity of renal glomerular cells is poorly characterized and rodent glomerulopathy models translate poorly to humans. Here, the authors show molecular signatures of glomerulus-associated cells using single cell RNA sequencing and highlight differences between mouse and human cells. |
format |
article |
author |
Bing He Ping Chen Sonia Zambrano Dina Dabaghie Yizhou Hu Katja Möller-Hackbarth David Unnersjö-Jess Gül Gizem Korkut Emmanuelle Charrin Marie Jeansson Maria Bintanel-Morcillo Anna Witasp Lars Wennberg Annika Wernerson Bernhard Schermer Thomas Benzing Patrik Ernfors Christer Betsholtz Mark Lal Rickard Sandberg Jaakko Patrakka |
author_facet |
Bing He Ping Chen Sonia Zambrano Dina Dabaghie Yizhou Hu Katja Möller-Hackbarth David Unnersjö-Jess Gül Gizem Korkut Emmanuelle Charrin Marie Jeansson Maria Bintanel-Morcillo Anna Witasp Lars Wennberg Annika Wernerson Bernhard Schermer Thomas Benzing Patrik Ernfors Christer Betsholtz Mark Lal Rickard Sandberg Jaakko Patrakka |
author_sort |
Bing He |
title |
Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes |
title_short |
Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes |
title_full |
Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes |
title_fullStr |
Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes |
title_full_unstemmed |
Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes |
title_sort |
single-cell rna sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/fe04160ada134a20a0af7aef65e1f106 |
work_keys_str_mv |
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