Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes

The molecular identity of renal glomerular cells is poorly characterized and rodent glomerulopathy models translate poorly to humans. Here, the authors show molecular signatures of glomerulus-associated cells using single cell RNA sequencing and highlight differences between mouse and human cells.

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Autores principales: Bing He, Ping Chen, Sonia Zambrano, Dina Dabaghie, Yizhou Hu, Katja Möller-Hackbarth, David Unnersjö-Jess, Gül Gizem Korkut, Emmanuelle Charrin, Marie Jeansson, Maria Bintanel-Morcillo, Anna Witasp, Lars Wennberg, Annika Wernerson, Bernhard Schermer, Thomas Benzing, Patrik Ernfors, Christer Betsholtz, Mark Lal, Rickard Sandberg, Jaakko Patrakka
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/fe04160ada134a20a0af7aef65e1f106
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spelling oai:doaj.org-article:fe04160ada134a20a0af7aef65e1f1062021-12-02T14:37:13ZSingle-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes10.1038/s41467-021-22331-92041-1723https://doaj.org/article/fe04160ada134a20a0af7aef65e1f1062021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22331-9https://doaj.org/toc/2041-1723The molecular identity of renal glomerular cells is poorly characterized and rodent glomerulopathy models translate poorly to humans. Here, the authors show molecular signatures of glomerulus-associated cells using single cell RNA sequencing and highlight differences between mouse and human cells.Bing HePing ChenSonia ZambranoDina DabaghieYizhou HuKatja Möller-HackbarthDavid Unnersjö-JessGül Gizem KorkutEmmanuelle CharrinMarie JeanssonMaria Bintanel-MorcilloAnna WitaspLars WennbergAnnika WernersonBernhard SchermerThomas BenzingPatrik ErnforsChrister BetsholtzMark LalRickard SandbergJaakko PatrakkaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Bing He
Ping Chen
Sonia Zambrano
Dina Dabaghie
Yizhou Hu
Katja Möller-Hackbarth
David Unnersjö-Jess
Gül Gizem Korkut
Emmanuelle Charrin
Marie Jeansson
Maria Bintanel-Morcillo
Anna Witasp
Lars Wennberg
Annika Wernerson
Bernhard Schermer
Thomas Benzing
Patrik Ernfors
Christer Betsholtz
Mark Lal
Rickard Sandberg
Jaakko Patrakka
Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes
description The molecular identity of renal glomerular cells is poorly characterized and rodent glomerulopathy models translate poorly to humans. Here, the authors show molecular signatures of glomerulus-associated cells using single cell RNA sequencing and highlight differences between mouse and human cells.
format article
author Bing He
Ping Chen
Sonia Zambrano
Dina Dabaghie
Yizhou Hu
Katja Möller-Hackbarth
David Unnersjö-Jess
Gül Gizem Korkut
Emmanuelle Charrin
Marie Jeansson
Maria Bintanel-Morcillo
Anna Witasp
Lars Wennberg
Annika Wernerson
Bernhard Schermer
Thomas Benzing
Patrik Ernfors
Christer Betsholtz
Mark Lal
Rickard Sandberg
Jaakko Patrakka
author_facet Bing He
Ping Chen
Sonia Zambrano
Dina Dabaghie
Yizhou Hu
Katja Möller-Hackbarth
David Unnersjö-Jess
Gül Gizem Korkut
Emmanuelle Charrin
Marie Jeansson
Maria Bintanel-Morcillo
Anna Witasp
Lars Wennberg
Annika Wernerson
Bernhard Schermer
Thomas Benzing
Patrik Ernfors
Christer Betsholtz
Mark Lal
Rickard Sandberg
Jaakko Patrakka
author_sort Bing He
title Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes
title_short Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes
title_full Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes
title_fullStr Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes
title_full_unstemmed Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes
title_sort single-cell rna sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/fe04160ada134a20a0af7aef65e1f106
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