Gelatinase-sensitive nanoparticles loaded with photosensitizer and STAT3 inhibitor for cancer photothermal therapy and immunotherapy

Abstract Matrix metalloproteinase (MMP) 2 and 9 are the family members of proteases normally up-regulated in tumor to enhance the invasion and metastatic of tumor cells, and are associated with poor outcome of head and neck squamous cell carcinomas (HNSCCs). In the present work, MMPs-degradable gela...

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Autores principales:	Lin-Lin Bu, Han-Qi Wang, Yuanwei Pan, Lei Chen, Hao Wu, Xianjia Wu, Chenchen Zhao, Lang Rao, Bing Liu, Zhi-Jun Sun
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Stimuli-responsive drug release Indocyanine green, STAT3 inhibitor Immunotherapy Photothermal therapy Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/fe045bb0428b47e7a4f70148bf88f5c7
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spelling	oai:doaj.org-article:fe045bb0428b47e7a4f70148bf88f5c72021-11-28T12:26:43ZGelatinase-sensitive nanoparticles loaded with photosensitizer and STAT3 inhibitor for cancer photothermal therapy and immunotherapy10.1186/s12951-021-01125-71477-3155https://doaj.org/article/fe045bb0428b47e7a4f70148bf88f5c72021-11-01T00:00:00Zhttps://doi.org/10.1186/s12951-021-01125-7https://doaj.org/toc/1477-3155Abstract Matrix metalloproteinase (MMP) 2 and 9 are the family members of proteases normally up-regulated in tumor to enhance the invasion and metastatic of tumor cells, and are associated with poor outcome of head and neck squamous cell carcinomas (HNSCCs). In the present work, MMPs-degradable gelatin nanoparticles (GNPs) are simultaneously loaded with photosensitizer indocyanine green (ICG) along with signal transducer activator of transcription 3 (STAT3) inhibitor NSC74859 (NSC, N) for efficient photothermal therapy (PTT) and immunotherapy of HNSCCs. In the tumor tissue, Gel-N-ICG nanoparticle was degraded and encapsulated ICG and NSC were effectively released. Under near-infrared (NIR) irradiation, the released ICG nanoparticles enabled effective photothermal destruction of tumors, and the STAT3 inhibitor NSC elicited potent antitumor immunity for enhanced cancer therapy. Based on two HNSCC mouse models, we demonstrated that Gel-N-ICG significantly delayed tumor growth without any appreciable body weight loss. Taken together, the strategy reported here may contribute that the stimuli-responsive proteases triggered nanoplatform could reduce tumor size more effectively in complex tumor microenvironment (TME) through combination of PTT and immunotherapy. Graphical AbstractLin-Lin BuHan-Qi WangYuanwei PanLei ChenHao WuXianjia WuChenchen ZhaoLang RaoBing LiuZhi-Jun SunBMCarticleStimuli-responsive drug releaseIndocyanine green, STAT3 inhibitorImmunotherapyPhotothermal therapyBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENJournal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Stimuli-responsive drug release Indocyanine green, STAT3 inhibitor Immunotherapy Photothermal therapy Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	Stimuli-responsive drug release Indocyanine green, STAT3 inhibitor Immunotherapy Photothermal therapy Biotechnology TP248.13-248.65 Medical technology R855-855.5 Lin-Lin Bu Han-Qi Wang Yuanwei Pan Lei Chen Hao Wu Xianjia Wu Chenchen Zhao Lang Rao Bing Liu Zhi-Jun Sun Gelatinase-sensitive nanoparticles loaded with photosensitizer and STAT3 inhibitor for cancer photothermal therapy and immunotherapy
description	Abstract Matrix metalloproteinase (MMP) 2 and 9 are the family members of proteases normally up-regulated in tumor to enhance the invasion and metastatic of tumor cells, and are associated with poor outcome of head and neck squamous cell carcinomas (HNSCCs). In the present work, MMPs-degradable gelatin nanoparticles (GNPs) are simultaneously loaded with photosensitizer indocyanine green (ICG) along with signal transducer activator of transcription 3 (STAT3) inhibitor NSC74859 (NSC, N) for efficient photothermal therapy (PTT) and immunotherapy of HNSCCs. In the tumor tissue, Gel-N-ICG nanoparticle was degraded and encapsulated ICG and NSC were effectively released. Under near-infrared (NIR) irradiation, the released ICG nanoparticles enabled effective photothermal destruction of tumors, and the STAT3 inhibitor NSC elicited potent antitumor immunity for enhanced cancer therapy. Based on two HNSCC mouse models, we demonstrated that Gel-N-ICG significantly delayed tumor growth without any appreciable body weight loss. Taken together, the strategy reported here may contribute that the stimuli-responsive proteases triggered nanoplatform could reduce tumor size more effectively in complex tumor microenvironment (TME) through combination of PTT and immunotherapy. Graphical Abstract
format	article
author	Lin-Lin Bu Han-Qi Wang Yuanwei Pan Lei Chen Hao Wu Xianjia Wu Chenchen Zhao Lang Rao Bing Liu Zhi-Jun Sun
author_facet	Lin-Lin Bu Han-Qi Wang Yuanwei Pan Lei Chen Hao Wu Xianjia Wu Chenchen Zhao Lang Rao Bing Liu Zhi-Jun Sun
author_sort	Lin-Lin Bu
title	Gelatinase-sensitive nanoparticles loaded with photosensitizer and STAT3 inhibitor for cancer photothermal therapy and immunotherapy
title_short	Gelatinase-sensitive nanoparticles loaded with photosensitizer and STAT3 inhibitor for cancer photothermal therapy and immunotherapy
title_full	Gelatinase-sensitive nanoparticles loaded with photosensitizer and STAT3 inhibitor for cancer photothermal therapy and immunotherapy
title_fullStr	Gelatinase-sensitive nanoparticles loaded with photosensitizer and STAT3 inhibitor for cancer photothermal therapy and immunotherapy
title_full_unstemmed	Gelatinase-sensitive nanoparticles loaded with photosensitizer and STAT3 inhibitor for cancer photothermal therapy and immunotherapy
title_sort	gelatinase-sensitive nanoparticles loaded with photosensitizer and stat3 inhibitor for cancer photothermal therapy and immunotherapy
publisher	BMC
publishDate	2021
url	https://doaj.org/article/fe045bb0428b47e7a4f70148bf88f5c7
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Gelatinase-sensitive nanoparticles loaded with photosensitizer and STAT3 inhibitor for cancer photothermal therapy and immunotherapy

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