Microglial metabolic flexibility supports immune surveillance of the brain parenchyma

Glucose is the main source of fuel in the brain. Here, the authors show that in the absence of glucose, glutamine is required for microglia to maintain their immune surveillance function.

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Autores principales:	Louis-Philippe Bernier, Elisa M. York, Alireza Kamyabi, Hyun B. Choi, Nicholas L. Weilinger, Brian A. MacVicar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fe06297fc77c43a5ab302576cc98adf4
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spelling	oai:doaj.org-article:fe06297fc77c43a5ab302576cc98adf42021-12-02T17:32:58ZMicroglial metabolic flexibility supports immune surveillance of the brain parenchyma10.1038/s41467-020-15267-z2041-1723https://doaj.org/article/fe06297fc77c43a5ab302576cc98adf42020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15267-zhttps://doaj.org/toc/2041-1723Glucose is the main source of fuel in the brain. Here, the authors show that in the absence of glucose, glutamine is required for microglia to maintain their immune surveillance function.Louis-Philippe BernierElisa M. YorkAlireza KamyabiHyun B. ChoiNicholas L. WeilingerBrian A. MacVicarNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Louis-Philippe Bernier Elisa M. York Alireza Kamyabi Hyun B. Choi Nicholas L. Weilinger Brian A. MacVicar Microglial metabolic flexibility supports immune surveillance of the brain parenchyma
description	Glucose is the main source of fuel in the brain. Here, the authors show that in the absence of glucose, glutamine is required for microglia to maintain their immune surveillance function.
format	article
author	Louis-Philippe Bernier Elisa M. York Alireza Kamyabi Hyun B. Choi Nicholas L. Weilinger Brian A. MacVicar
author_facet	Louis-Philippe Bernier Elisa M. York Alireza Kamyabi Hyun B. Choi Nicholas L. Weilinger Brian A. MacVicar
author_sort	Louis-Philippe Bernier
title	Microglial metabolic flexibility supports immune surveillance of the brain parenchyma
title_short	Microglial metabolic flexibility supports immune surveillance of the brain parenchyma
title_full	Microglial metabolic flexibility supports immune surveillance of the brain parenchyma
title_fullStr	Microglial metabolic flexibility supports immune surveillance of the brain parenchyma
title_full_unstemmed	Microglial metabolic flexibility supports immune surveillance of the brain parenchyma
title_sort	microglial metabolic flexibility supports immune surveillance of the brain parenchyma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fe06297fc77c43a5ab302576cc98adf4
work_keys_str_mv	AT louisphilippebernier microglialmetabolicflexibilitysupportsimmunesurveillanceofthebrainparenchyma AT elisamyork microglialmetabolicflexibilitysupportsimmunesurveillanceofthebrainparenchyma AT alirezakamyabi microglialmetabolicflexibilitysupportsimmunesurveillanceofthebrainparenchyma AT hyunbchoi microglialmetabolicflexibilitysupportsimmunesurveillanceofthebrainparenchyma AT nicholaslweilinger microglialmetabolicflexibilitysupportsimmunesurveillanceofthebrainparenchyma AT brianamacvicar microglialmetabolicflexibilitysupportsimmunesurveillanceofthebrainparenchyma
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Microglial metabolic flexibility supports immune surveillance of the brain parenchyma

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