Non-calorimetric determination of absorbed power during magnetic nanoparticle based hyperthermia

Abstract Nanomagnetic hyperthermia (NMH) is intensively studied with the prospect of cancer therapy. A major challenge is to determine the dissipated power during in vivo conditions and conventional methods are either invasive or inaccurate. We present a non-calorimetric method which yields the heat...

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Autores principales:	I. Gresits, Gy. Thuróczy, O. Sági, B. Gyüre-Garami, B. G. Márkus, F. Simon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fe066344e1f24176a3b071d3e5b5ac43
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spelling	oai:doaj.org-article:fe066344e1f24176a3b071d3e5b5ac432021-12-02T15:08:30ZNon-calorimetric determination of absorbed power during magnetic nanoparticle based hyperthermia10.1038/s41598-018-30981-x2045-2322https://doaj.org/article/fe066344e1f24176a3b071d3e5b5ac432018-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-30981-xhttps://doaj.org/toc/2045-2322Abstract Nanomagnetic hyperthermia (NMH) is intensively studied with the prospect of cancer therapy. A major challenge is to determine the dissipated power during in vivo conditions and conventional methods are either invasive or inaccurate. We present a non-calorimetric method which yields the heat absorbed during hyperthermia: it is based on accurately measuring the quality factor change of a resonant radio frequency circuit which is employed for the irradiation. The approach provides the absorbed power in real-time, without the need to monitor the sample temperature as a function of time. As such, it is free from the problems caused by the non-adiabatic heating conditions of the usual calorimetry. We validate the method by comparing the dissipated power with a conventional calorimetric measurement. We present the validation for two types of resonators with very different filling factors: a solenoid and a so-called birdcage coil. The latter is a volume coil, which is generally used in magnetic resonance imaging (MRI) under in vivo condition. The presented method therefore allows to effectively combine MRI and thermotherapy and is thus readily adaptable to existing imaging hardware.I. GresitsGy. ThuróczyO. SágiB. Gyüre-GaramiB. G. MárkusF. SimonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q I. Gresits Gy. Thuróczy O. Sági B. Gyüre-Garami B. G. Márkus F. Simon Non-calorimetric determination of absorbed power during magnetic nanoparticle based hyperthermia
description	Abstract Nanomagnetic hyperthermia (NMH) is intensively studied with the prospect of cancer therapy. A major challenge is to determine the dissipated power during in vivo conditions and conventional methods are either invasive or inaccurate. We present a non-calorimetric method which yields the heat absorbed during hyperthermia: it is based on accurately measuring the quality factor change of a resonant radio frequency circuit which is employed for the irradiation. The approach provides the absorbed power in real-time, without the need to monitor the sample temperature as a function of time. As such, it is free from the problems caused by the non-adiabatic heating conditions of the usual calorimetry. We validate the method by comparing the dissipated power with a conventional calorimetric measurement. We present the validation for two types of resonators with very different filling factors: a solenoid and a so-called birdcage coil. The latter is a volume coil, which is generally used in magnetic resonance imaging (MRI) under in vivo condition. The presented method therefore allows to effectively combine MRI and thermotherapy and is thus readily adaptable to existing imaging hardware.
format	article
author	I. Gresits Gy. Thuróczy O. Sági B. Gyüre-Garami B. G. Márkus F. Simon
author_facet	I. Gresits Gy. Thuróczy O. Sági B. Gyüre-Garami B. G. Márkus F. Simon
author_sort	I. Gresits
title	Non-calorimetric determination of absorbed power during magnetic nanoparticle based hyperthermia
title_short	Non-calorimetric determination of absorbed power during magnetic nanoparticle based hyperthermia
title_full	Non-calorimetric determination of absorbed power during magnetic nanoparticle based hyperthermia
title_fullStr	Non-calorimetric determination of absorbed power during magnetic nanoparticle based hyperthermia
title_full_unstemmed	Non-calorimetric determination of absorbed power during magnetic nanoparticle based hyperthermia
title_sort	non-calorimetric determination of absorbed power during magnetic nanoparticle based hyperthermia
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fe066344e1f24176a3b071d3e5b5ac43
work_keys_str_mv	AT igresits noncalorimetricdeterminationofabsorbedpowerduringmagneticnanoparticlebasedhyperthermia AT gythuroczy noncalorimetricdeterminationofabsorbedpowerduringmagneticnanoparticlebasedhyperthermia AT osagi noncalorimetricdeterminationofabsorbedpowerduringmagneticnanoparticlebasedhyperthermia AT bgyuregarami noncalorimetricdeterminationofabsorbedpowerduringmagneticnanoparticlebasedhyperthermia AT bgmarkus noncalorimetricdeterminationofabsorbedpowerduringmagneticnanoparticlebasedhyperthermia AT fsimon noncalorimetricdeterminationofabsorbedpowerduringmagneticnanoparticlebasedhyperthermia
_version_	1718388165478187008

Non-calorimetric determination of absorbed power during magnetic nanoparticle based hyperthermia

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