INFLUENCE ON CELLULAR TARGETS FOR TREATING INFLUENZA INFECTION

Аbstract. Influenza is a highly contagious infection of humans. The use of specific antivirals leads to emergence of drug-resistant strains following by the decrease of efficacy of ethiotropic chemotherapy. In this review the data about the decrease of the level of viral replication and severity of...

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Autores principales:	V. V. Zarubaev, V. S. Smirnov
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	influenza host targets inflammation signal pathways antivirals Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/fe097333745c408da5e755e99167263b
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spelling	oai:doaj.org-article:fe097333745c408da5e755e99167263b2021-11-22T07:09:46ZINFLUENCE ON CELLULAR TARGETS FOR TREATING INFLUENZA INFECTION2220-76192313-739810.15789/2220-7619-2014-1-15-26https://doaj.org/article/fe097333745c408da5e755e99167263b2014-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/153https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Аbstract. Influenza is a highly contagious infection of humans. The use of specific antivirals leads to emergence of drug-resistant strains following by the decrease of efficacy of ethiotropic chemotherapy. In this review the data about the decrease of the level of viral replication and severity of pathological process based on the use of alternative targets of cellular instead of viral origin are presented. The medicines for decreasing the production of proinflammatory cytokines (eritoran), restricting the degranulation of mast cells (ketotifen), inhibitors of cyclooxygenases (celexocib, mesalasine, SC-560), inhibitors of sphingosine-1-phospate pathway (AAL-R) and compounds increasing the capillars stability by strengthe ning the contacts between endothelial cells (Slit protein) have been described in the review. The special attention is paid to the inhibitors of cellular pathways that are used by the virus to provide its reproduction, such as NF-κB, Raf/MEK/ERK, PI3K/AKT/mTOR. Information concerning anti-influenza activity of kinase and autophagy inhibitors is summarised as well as data about the preparations of combined mechanism of activity — glycirrhizic acid and dipeptide alpha-glutamyl-tryptophane. Further studies in the field of search and optimization of inhibitors of cellular components as remedies against influenza infection could lead to the development of novel antivirals with high efficacy, broad spectrum of activity and low probability of virus resistance.V. V. ZarubaevV. S. SmirnovSankt-Peterburg : NIIÈM imeni Pasteraarticleinfluenzahost targetsinflammationsignal pathwaysantiviralsInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 4, Iss 1, Pp 15-26 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	influenza host targets inflammation signal pathways antivirals Infectious and parasitic diseases RC109-216
spellingShingle	influenza host targets inflammation signal pathways antivirals Infectious and parasitic diseases RC109-216 V. V. Zarubaev V. S. Smirnov INFLUENCE ON CELLULAR TARGETS FOR TREATING INFLUENZA INFECTION
description	Аbstract. Influenza is a highly contagious infection of humans. The use of specific antivirals leads to emergence of drug-resistant strains following by the decrease of efficacy of ethiotropic chemotherapy. In this review the data about the decrease of the level of viral replication and severity of pathological process based on the use of alternative targets of cellular instead of viral origin are presented. The medicines for decreasing the production of proinflammatory cytokines (eritoran), restricting the degranulation of mast cells (ketotifen), inhibitors of cyclooxygenases (celexocib, mesalasine, SC-560), inhibitors of sphingosine-1-phospate pathway (AAL-R) and compounds increasing the capillars stability by strengthe ning the contacts between endothelial cells (Slit protein) have been described in the review. The special attention is paid to the inhibitors of cellular pathways that are used by the virus to provide its reproduction, such as NF-κB, Raf/MEK/ERK, PI3K/AKT/mTOR. Information concerning anti-influenza activity of kinase and autophagy inhibitors is summarised as well as data about the preparations of combined mechanism of activity — glycirrhizic acid and dipeptide alpha-glutamyl-tryptophane. Further studies in the field of search and optimization of inhibitors of cellular components as remedies against influenza infection could lead to the development of novel antivirals with high efficacy, broad spectrum of activity and low probability of virus resistance.
format	article
author	V. V. Zarubaev V. S. Smirnov
author_facet	V. V. Zarubaev V. S. Smirnov
author_sort	V. V. Zarubaev
title	INFLUENCE ON CELLULAR TARGETS FOR TREATING INFLUENZA INFECTION
title_short	INFLUENCE ON CELLULAR TARGETS FOR TREATING INFLUENZA INFECTION
title_full	INFLUENCE ON CELLULAR TARGETS FOR TREATING INFLUENZA INFECTION
title_fullStr	INFLUENCE ON CELLULAR TARGETS FOR TREATING INFLUENZA INFECTION
title_full_unstemmed	INFLUENCE ON CELLULAR TARGETS FOR TREATING INFLUENZA INFECTION
title_sort	influence on cellular targets for treating influenza infection
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/fe097333745c408da5e755e99167263b
work_keys_str_mv	AT vvzarubaev influenceoncellulartargetsfortreatinginfluenzainfection AT vssmirnov influenceoncellulartargetsfortreatinginfluenzainfection
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INFLUENCE ON CELLULAR TARGETS FOR TREATING INFLUENZA INFECTION

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