Risk of cancer development in patients with keloids

Abstract Keloid is a skin disease characterized by exaggerated scar formation, excessive fibroblast proliferation, and excessive collagen deposition. Cancers commonly arise from a fibrotic microenvironment; e.g., hepatoma arises from liver cirrhosis, and oral cancers arise from submucosal fibrosis....

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Autores principales:	Ying-Yi Lu, Hung-Pin Tu, Chieh-Hsin Wu, Chien-Hui Hong, Kuo-Chia Yang, Hui-Ju Yang, Kee-Lung Chang, Chih-Hung Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fe09bc60044543758613bb01e5ae9326
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spelling	oai:doaj.org-article:fe09bc60044543758613bb01e5ae93262021-12-02T16:55:25ZRisk of cancer development in patients with keloids10.1038/s41598-021-88789-12045-2322https://doaj.org/article/fe09bc60044543758613bb01e5ae93262021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88789-1https://doaj.org/toc/2045-2322Abstract Keloid is a skin disease characterized by exaggerated scar formation, excessive fibroblast proliferation, and excessive collagen deposition. Cancers commonly arise from a fibrotic microenvironment; e.g., hepatoma arises from liver cirrhosis, and oral cancers arise from submucosal fibrosis. As keloids are a prototypic fibroproliferative disease, this study investigated whether patients with keloids have an increased cancer risk. In a matched, population-based study, first 17,401 patients treated for keloids during 1998–2010 with 69,604 controls without keloids at a ratio of 1:4 were evaluated. The association between keloids and risk of cancer was estimated by logistic regression or Cox proportional hazard regression models after adjustment of covariates. In total, 893 first-time cases of cancer were identified in the 17,401 patients with keloids. The overall cancer risk was 1.49-fold higher in the keloids group compared to controls. Regarding specific cancers, the keloids group, had a significantly higher risk of skin cancer compared to controls (Relative risk = 1.73). The relative risk for skin cancer was even higher for males with keloids (Relative risk = 2.16). Further stratified analyses also revealed a significantly higher risk of developing pancreatic cancer in female patients with keloids compared to controls (Relative risk = 2.19) after adjustment for known pancreatic cancer risk factors. This study indicates that patients with keloids have a higher than normal risk for several cancer types, especially skin cancers (both genders) and pancreatic cancer (females). Therefore, patients with keloids should undergo regular skin examinations, and females with keloids should regularly undergo abdominal ultrasonography.Ying-Yi LuHung-Pin TuChieh-Hsin WuChien-Hui HongKuo-Chia YangHui-Ju YangKee-Lung ChangChih-Hung LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ying-Yi Lu Hung-Pin Tu Chieh-Hsin Wu Chien-Hui Hong Kuo-Chia Yang Hui-Ju Yang Kee-Lung Chang Chih-Hung Lee Risk of cancer development in patients with keloids
description	Abstract Keloid is a skin disease characterized by exaggerated scar formation, excessive fibroblast proliferation, and excessive collagen deposition. Cancers commonly arise from a fibrotic microenvironment; e.g., hepatoma arises from liver cirrhosis, and oral cancers arise from submucosal fibrosis. As keloids are a prototypic fibroproliferative disease, this study investigated whether patients with keloids have an increased cancer risk. In a matched, population-based study, first 17,401 patients treated for keloids during 1998–2010 with 69,604 controls without keloids at a ratio of 1:4 were evaluated. The association between keloids and risk of cancer was estimated by logistic regression or Cox proportional hazard regression models after adjustment of covariates. In total, 893 first-time cases of cancer were identified in the 17,401 patients with keloids. The overall cancer risk was 1.49-fold higher in the keloids group compared to controls. Regarding specific cancers, the keloids group, had a significantly higher risk of skin cancer compared to controls (Relative risk = 1.73). The relative risk for skin cancer was even higher for males with keloids (Relative risk = 2.16). Further stratified analyses also revealed a significantly higher risk of developing pancreatic cancer in female patients with keloids compared to controls (Relative risk = 2.19) after adjustment for known pancreatic cancer risk factors. This study indicates that patients with keloids have a higher than normal risk for several cancer types, especially skin cancers (both genders) and pancreatic cancer (females). Therefore, patients with keloids should undergo regular skin examinations, and females with keloids should regularly undergo abdominal ultrasonography.
format	article
author	Ying-Yi Lu Hung-Pin Tu Chieh-Hsin Wu Chien-Hui Hong Kuo-Chia Yang Hui-Ju Yang Kee-Lung Chang Chih-Hung Lee
author_facet	Ying-Yi Lu Hung-Pin Tu Chieh-Hsin Wu Chien-Hui Hong Kuo-Chia Yang Hui-Ju Yang Kee-Lung Chang Chih-Hung Lee
author_sort	Ying-Yi Lu
title	Risk of cancer development in patients with keloids
title_short	Risk of cancer development in patients with keloids
title_full	Risk of cancer development in patients with keloids
title_fullStr	Risk of cancer development in patients with keloids
title_full_unstemmed	Risk of cancer development in patients with keloids
title_sort	risk of cancer development in patients with keloids
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fe09bc60044543758613bb01e5ae9326
work_keys_str_mv	AT yingyilu riskofcancerdevelopmentinpatientswithkeloids AT hungpintu riskofcancerdevelopmentinpatientswithkeloids AT chiehhsinwu riskofcancerdevelopmentinpatientswithkeloids AT chienhuihong riskofcancerdevelopmentinpatientswithkeloids AT kuochiayang riskofcancerdevelopmentinpatientswithkeloids AT huijuyang riskofcancerdevelopmentinpatientswithkeloids AT keelungchang riskofcancerdevelopmentinpatientswithkeloids AT chihhunglee riskofcancerdevelopmentinpatientswithkeloids
_version_	1718382897119887360

Risk of cancer development in patients with keloids

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