Persistence of Human Bocavirus 1 in Tonsillar Germinal Centers and Antibody-Dependent Enhancement of Infection

Human bocavirus 1 (HBoV1), a common pediatric respiratory pathogen, can persist in airway secretions for months hampering diagnosis. It also persists in tonsils, providing potential reservoirs for airway shedding, with the exact location, host cell types, and virus activity unknown.

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Detalles Bibliográficos
Autores principales: Man Xu, Maria Fernanda Perdomo, Salla Mattola, Lari Pyöriä, Mari Toppinen, Jianming Qiu, Maija Vihinen-Ranta, Klaus Hedman, Johanna Nokso-Koivisto, Leena-Maija Aaltonen, Maria Söderlund-Venermo
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
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Acceso en línea:https://doaj.org/article/fe108de5e10844ae9182f0124f92a550
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Descripción
Sumario:Human bocavirus 1 (HBoV1), a common pediatric respiratory pathogen, can persist in airway secretions for months hampering diagnosis. It also persists in tonsils, providing potential reservoirs for airway shedding, with the exact location, host cell types, and virus activity unknown.