Lipoxins: nature's way to resolve inflammation

Lipoxins: nature's way to resolve inflammation

Jayashree A Chandrasekharan, Neelam Sharma-Walia HM Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USAAbstract: An effective host defense mechanism involves inflammation t...

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Autores principales: Chandrasekharan JA, Sharma-Walia N
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
Materias:
Pathology
RB1-214
Therapeutics. Pharmacology
RM1-950
Acceso en línea:https://doaj.org/article/fe128f70ad644fa3b6879d1909baae30
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spelling oai:doaj.org-article:fe128f70ad644fa3b6879d1909baae302021-12-02T05:46:49ZLipoxins: nature's way to resolve inflammation1178-7031https://doaj.org/article/fe128f70ad644fa3b6879d1909baae302015-09-01T00:00:00Zhttps://www.dovepress.com/lipoxins-nature39s-way-to-resolve-inflammation-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Jayashree A Chandrasekharan, Neelam Sharma-Walia HM Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USAAbstract: An effective host defense mechanism involves inflammation to eliminate pathogens from the site of infection, followed by the resolution of inflammation and the restoration of tissue homeostasis. Lipoxins are endogenous anti-inflammatory, pro-resolving molecules that play a vital role in reducing excessive tissue injury and chronic inflammation. In this review, the mechanisms of action of lipoxins at the site of inflammation and their interaction with other cellular signaling molecules and transcription factors are discussed. Emphasis has also been placed on immune modulatory role(s) of lipoxins. Lipoxins regulate components of both the innate and adaptive immune systems including neutrophils, macrophages, T-, and B-cells. Lipoxins also modulate levels of various transcription factors such as nuclear factor κB, activator protein-1, nerve growth factor-regulated factor 1A binding protein 1, and peroxisome proliferator activated receptor γ and control the expression of many inflammatory genes. Since lipoxins and aspirin-triggered lipoxins have clinical relevance, we discuss their important role in clinical research to treat a wide range of diseases like inflammatory disorders, renal fibrosis, cerebral ischemia, and cancer. A brief overview of lipoxins in viral malignancies and viral pathogenesis especially the unexplored role of lipoxins in Kaposi's sarcoma-associated herpes virus biology is also presented. Keywords: lipoxins, epi-lipoxins, inflammation, pro-resolving, aspirin-triggered lipoxins, cyclooxygenases, lipoxygenases, therapeutic potential, transcription factors, Kaposi's sarcoma-associated herpes virusChandrasekharan JASharma-Walia NDove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2015, Iss default, Pp 181-192 (2015)
institution DOAJ
collection DOAJ
language EN
topic Pathology
RB1-214
Therapeutics. Pharmacology
RM1-950
spellingShingle Pathology
RB1-214
Therapeutics. Pharmacology
RM1-950
Chandrasekharan JA
Sharma-Walia N
Lipoxins: nature's way to resolve inflammation
description Jayashree A Chandrasekharan, Neelam Sharma-Walia HM Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USAAbstract: An effective host defense mechanism involves inflammation to eliminate pathogens from the site of infection, followed by the resolution of inflammation and the restoration of tissue homeostasis. Lipoxins are endogenous anti-inflammatory, pro-resolving molecules that play a vital role in reducing excessive tissue injury and chronic inflammation. In this review, the mechanisms of action of lipoxins at the site of inflammation and their interaction with other cellular signaling molecules and transcription factors are discussed. Emphasis has also been placed on immune modulatory role(s) of lipoxins. Lipoxins regulate components of both the innate and adaptive immune systems including neutrophils, macrophages, T-, and B-cells. Lipoxins also modulate levels of various transcription factors such as nuclear factor κB, activator protein-1, nerve growth factor-regulated factor 1A binding protein 1, and peroxisome proliferator activated receptor γ and control the expression of many inflammatory genes. Since lipoxins and aspirin-triggered lipoxins have clinical relevance, we discuss their important role in clinical research to treat a wide range of diseases like inflammatory disorders, renal fibrosis, cerebral ischemia, and cancer. A brief overview of lipoxins in viral malignancies and viral pathogenesis especially the unexplored role of lipoxins in Kaposi's sarcoma-associated herpes virus biology is also presented. Keywords: lipoxins, epi-lipoxins, inflammation, pro-resolving, aspirin-triggered lipoxins, cyclooxygenases, lipoxygenases, therapeutic potential, transcription factors, Kaposi's sarcoma-associated herpes virus
format article
author Chandrasekharan JA
Sharma-Walia N
author_facet Chandrasekharan JA
Sharma-Walia N
author_sort Chandrasekharan JA
title Lipoxins: nature's way to resolve inflammation
title_short Lipoxins: nature's way to resolve inflammation
title_full Lipoxins: nature's way to resolve inflammation
title_fullStr Lipoxins: nature's way to resolve inflammation
title_full_unstemmed Lipoxins: nature's way to resolve inflammation
title_sort lipoxins: nature's way to resolve inflammation
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/fe128f70ad644fa3b6879d1909baae30
work_keys_str_mv AT chandrasekharanja lipoxinsnature39swaytoresolveinflammation
AT sharmawalian lipoxinsnature39swaytoresolveinflammation
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