Fluctuations in waist circumference increase diabetes risk: a 4-year cohort study in 61,587 older adults

Abstract Purpose To evaluate the effect of fluctuations in waist circumference (WC), weight, and body mass index (BMI) on the incidence of diabetes in older adults. Patients and methods A prospective cohort of 61,587 older adults (age, 60–96 years) who did not have diabetes at study initiation was e...

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Autores principales:	Linna Wu, Hongyan Liu, Zhuang Cui, Fang Hou, Xiaowen Gong, Yourui Zhang, Chunlan Lu, Hao Liu, Pei Yu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Fluctuations WC Older adults Diabetes Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/fe12a7ed55d340df842ccb593419b51e
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spelling	oai:doaj.org-article:fe12a7ed55d340df842ccb593419b51e2021-11-14T12:15:19ZFluctuations in waist circumference increase diabetes risk: a 4-year cohort study in 61,587 older adults10.1186/s12986-021-00627-31743-7075https://doaj.org/article/fe12a7ed55d340df842ccb593419b51e2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12986-021-00627-3https://doaj.org/toc/1743-7075Abstract Purpose To evaluate the effect of fluctuations in waist circumference (WC), weight, and body mass index (BMI) on the incidence of diabetes in older adults. Patients and methods A prospective cohort of 61,587 older adults (age, 60–96 years) who did not have diabetes at study initiation was examined. Data on weight, BMI, and WC were collected, and participants were followed up until 31 December 2018. The main end point was new-onset diabetes. A Cox regression model was used to estimate the risk of diabetes (hazard ratios [HRs] and confidence intervals [CI]) in these participants. Results During a mean follow-up of 3.6 years, being overweight (HR [95% CI] 1.87 [1.62–2.17]), obesity (1.41 [1.26–1.59]), abdominal obesity (1.42 [1.28–1.58]), and obesity plus abdominal obesity at baseline (1.93 [1.66–2.25]) increased the risk of diabetes onset. Compared with older adults who “maintained normal WC”, those who “remained abdominally obese” (HR = 1.66), “became abdominally obese” (HR = 1.58), or “achieved normal WC” (HR = 1.36) were at a higher risk of diabetes onset, as well as those with an increase in WC > 3 cm or > 5% compared with the baseline level. Weight gain or loss > 6 kg or weight gain > 5%, increase or decrease in BMI > 2 kg/m2, or an increase in BMI > 10% were associated with a higher diabetes risk. The diabetes risk was reduced by 19% in overweight older adults who exercised daily. Conclusion For older adults, WC, BMI, and healthy weight maintenance reduce the diabetes risk. The findings may provide evidence for developing guidelines of proper weight and WC control for older adults.Linna WuHongyan LiuZhuang CuiFang HouXiaowen GongYourui ZhangChunlan LuHao LiuPei YuBMCarticleFluctuationsWCOlder adultsDiabetesNutrition. Foods and food supplyTX341-641Nutritional diseases. Deficiency diseasesRC620-627ENNutrition & Metabolism, Vol 18, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Fluctuations WC Older adults Diabetes Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	Fluctuations WC Older adults Diabetes Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627 Linna Wu Hongyan Liu Zhuang Cui Fang Hou Xiaowen Gong Yourui Zhang Chunlan Lu Hao Liu Pei Yu Fluctuations in waist circumference increase diabetes risk: a 4-year cohort study in 61,587 older adults
description	Abstract Purpose To evaluate the effect of fluctuations in waist circumference (WC), weight, and body mass index (BMI) on the incidence of diabetes in older adults. Patients and methods A prospective cohort of 61,587 older adults (age, 60–96 years) who did not have diabetes at study initiation was examined. Data on weight, BMI, and WC were collected, and participants were followed up until 31 December 2018. The main end point was new-onset diabetes. A Cox regression model was used to estimate the risk of diabetes (hazard ratios [HRs] and confidence intervals [CI]) in these participants. Results During a mean follow-up of 3.6 years, being overweight (HR [95% CI] 1.87 [1.62–2.17]), obesity (1.41 [1.26–1.59]), abdominal obesity (1.42 [1.28–1.58]), and obesity plus abdominal obesity at baseline (1.93 [1.66–2.25]) increased the risk of diabetes onset. Compared with older adults who “maintained normal WC”, those who “remained abdominally obese” (HR = 1.66), “became abdominally obese” (HR = 1.58), or “achieved normal WC” (HR = 1.36) were at a higher risk of diabetes onset, as well as those with an increase in WC > 3 cm or > 5% compared with the baseline level. Weight gain or loss > 6 kg or weight gain > 5%, increase or decrease in BMI > 2 kg/m2, or an increase in BMI > 10% were associated with a higher diabetes risk. The diabetes risk was reduced by 19% in overweight older adults who exercised daily. Conclusion For older adults, WC, BMI, and healthy weight maintenance reduce the diabetes risk. The findings may provide evidence for developing guidelines of proper weight and WC control for older adults.
format	article
author	Linna Wu Hongyan Liu Zhuang Cui Fang Hou Xiaowen Gong Yourui Zhang Chunlan Lu Hao Liu Pei Yu
author_facet	Linna Wu Hongyan Liu Zhuang Cui Fang Hou Xiaowen Gong Yourui Zhang Chunlan Lu Hao Liu Pei Yu
author_sort	Linna Wu
title	Fluctuations in waist circumference increase diabetes risk: a 4-year cohort study in 61,587 older adults
title_short	Fluctuations in waist circumference increase diabetes risk: a 4-year cohort study in 61,587 older adults
title_full	Fluctuations in waist circumference increase diabetes risk: a 4-year cohort study in 61,587 older adults
title_fullStr	Fluctuations in waist circumference increase diabetes risk: a 4-year cohort study in 61,587 older adults
title_full_unstemmed	Fluctuations in waist circumference increase diabetes risk: a 4-year cohort study in 61,587 older adults
title_sort	fluctuations in waist circumference increase diabetes risk: a 4-year cohort study in 61,587 older adults
publisher	BMC
publishDate	2021
url	https://doaj.org/article/fe12a7ed55d340df842ccb593419b51e
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Fluctuations in waist circumference increase diabetes risk: a 4-year cohort study in 61,587 older adults

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