Wolbachia-mediated male killing is associated with defective chromatin remodeling.

Male killing, induced by different bacterial taxa of maternally inherited microorganisms, resulting in highly distorted female-biased sex-ratios, is a common phenomenon among arthropods. Some strains of the endosymbiont bacteria Wolbachia have been shown to induce this phenotype in particular insect...

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Autores principales:	Maria Giovanna Riparbelli, Rosanna Giordano, Morio Ueyama, Giuliano Callaini
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fe12fd362d5b468793bd5dd07a880e3f
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spelling	oai:doaj.org-article:fe12fd362d5b468793bd5dd07a880e3f2021-11-18T07:29:40ZWolbachia-mediated male killing is associated with defective chromatin remodeling.1932-620310.1371/journal.pone.0030045https://doaj.org/article/fe12fd362d5b468793bd5dd07a880e3f2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22291901/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Male killing, induced by different bacterial taxa of maternally inherited microorganisms, resulting in highly distorted female-biased sex-ratios, is a common phenomenon among arthropods. Some strains of the endosymbiont bacteria Wolbachia have been shown to induce this phenotype in particular insect hosts. High altitude populations of Drosophila bifasciata infected with Wolbachia show selective male killing during embryonic development. However, since this was first reported, circa 60 years ago, the interaction between Wolbachia and its host has remained unclear. Herein we show that D. bifasciata male embryos display defective chromatin remodeling, improper chromatid segregation and chromosome bridging, as well as abnormal mitotic spindles and gradual loss of their centrosomes. These defects occur at different times in the early development of male embryos leading to death during early nuclear division cycles or large defective areas of the cellular blastoderm, culminating in abnormal embryos that die before eclosion. We propose that Wolbachia affects the development of male embryos by specifically targeting male chromatin remodeling and thus disturbing mitotic spindle assembly and chromosome behavior. These are the first observations that demonstrate fundamental aspects of the cytological mechanism of male killing and represent a solid base for further molecular studies of this phenomenon.Maria Giovanna RiparbelliRosanna GiordanoMorio UeyamaGiuliano CallainiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e30045 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Giovanna Riparbelli Rosanna Giordano Morio Ueyama Giuliano Callaini Wolbachia-mediated male killing is associated with defective chromatin remodeling.
description	Male killing, induced by different bacterial taxa of maternally inherited microorganisms, resulting in highly distorted female-biased sex-ratios, is a common phenomenon among arthropods. Some strains of the endosymbiont bacteria Wolbachia have been shown to induce this phenotype in particular insect hosts. High altitude populations of Drosophila bifasciata infected with Wolbachia show selective male killing during embryonic development. However, since this was first reported, circa 60 years ago, the interaction between Wolbachia and its host has remained unclear. Herein we show that D. bifasciata male embryos display defective chromatin remodeling, improper chromatid segregation and chromosome bridging, as well as abnormal mitotic spindles and gradual loss of their centrosomes. These defects occur at different times in the early development of male embryos leading to death during early nuclear division cycles or large defective areas of the cellular blastoderm, culminating in abnormal embryos that die before eclosion. We propose that Wolbachia affects the development of male embryos by specifically targeting male chromatin remodeling and thus disturbing mitotic spindle assembly and chromosome behavior. These are the first observations that demonstrate fundamental aspects of the cytological mechanism of male killing and represent a solid base for further molecular studies of this phenomenon.
format	article
author	Maria Giovanna Riparbelli Rosanna Giordano Morio Ueyama Giuliano Callaini
author_facet	Maria Giovanna Riparbelli Rosanna Giordano Morio Ueyama Giuliano Callaini
author_sort	Maria Giovanna Riparbelli
title	Wolbachia-mediated male killing is associated with defective chromatin remodeling.
title_short	Wolbachia-mediated male killing is associated with defective chromatin remodeling.
title_full	Wolbachia-mediated male killing is associated with defective chromatin remodeling.
title_fullStr	Wolbachia-mediated male killing is associated with defective chromatin remodeling.
title_full_unstemmed	Wolbachia-mediated male killing is associated with defective chromatin remodeling.
title_sort	wolbachia-mediated male killing is associated with defective chromatin remodeling.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/fe12fd362d5b468793bd5dd07a880e3f
work_keys_str_mv	AT mariagiovannariparbelli wolbachiamediatedmalekillingisassociatedwithdefectivechromatinremodeling AT rosannagiordano wolbachiamediatedmalekillingisassociatedwithdefectivechromatinremodeling AT morioueyama wolbachiamediatedmalekillingisassociatedwithdefectivechromatinremodeling AT giulianocallaini wolbachiamediatedmalekillingisassociatedwithdefectivechromatinremodeling
_version_	1718423387926167552

Wolbachia-mediated male killing is associated with defective chromatin remodeling.

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