Effectiveness of Medicinal Plants for Glycaemic Control in Type 2 Diabetes: An Overview of Meta-Analyses of Clinical Trials

Aims: To rank the effectiveness of medicinal plants for glycaemic control in Type 2 Diabetes (T2DM).Methods: MEDLINE, EMBASE, CINAHL and Cochrane Central were searched in October 2020. We included meta-analyses of randomised controlled clinical trials measuring the effectiveness of medicinal plants...

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Autores principales:	Merlin L. Willcox, Christina Elugbaju, Marwah Al-Anbaki, Mark Lown, Bertrand Graz
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	type 2 diabetes mellitus phytomedicines medicinal plants herbal preparations metaanalysis randomised controlled clinical trials Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/fe153d293c0444f49e9e1513cd09841f
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spelling	oai:doaj.org-article:fe153d293c0444f49e9e1513cd09841f2021-12-01T07:47:50ZEffectiveness of Medicinal Plants for Glycaemic Control in Type 2 Diabetes: An Overview of Meta-Analyses of Clinical Trials1663-981210.3389/fphar.2021.777561https://doaj.org/article/fe153d293c0444f49e9e1513cd09841f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.777561/fullhttps://doaj.org/toc/1663-9812Aims: To rank the effectiveness of medicinal plants for glycaemic control in Type 2 Diabetes (T2DM).Methods: MEDLINE, EMBASE, CINAHL and Cochrane Central were searched in October 2020. We included meta-analyses of randomised controlled clinical trials measuring the effectiveness of medicinal plants on HbA1c and/or Fasting Plasma Glucose (FPG) in patients with T2DM.Results: Twenty five meta-analyses reported the effects of 18 plant-based remedies. Aloe vera leaf gel, Psyllium fibre and Fenugreek seeds had the largest effects on HbA1c: mean difference –0.99% [95% CI−1.75, −0.23], −0.97% [95% CI −1.94, −0.01] and −0.85% [95% CI −1.49, −0.22] respectively. Four other remedies reduced HbA1c by at least 0.5%: Nigellasativa, Astragalus membranaceus, and the traditional Chinese formulae Jinqi Jiangtang and Gegen Qinlian. No serious adverse effects were reported. Several other herbal medicines significantly reduced FPG. Tea and tea extracts (Camellia sinensis) were ineffective. However, in some trials duration of follow-up was insufficient to measure the full effect on HbA1c (<8 weeks). Many herbal remedies had not been evaluated in a meta-analysis.Conclusion: Several medicinal plants appear to be as effective as conventional antidiabetic treatments for reducing HbA1c. Rigorous trials with at least 3 months’ follow-up are needed to ascertain the effects of promising plant-based preparations on diabetes.Merlin L. WillcoxChristina ElugbajuMarwah Al-AnbakiMark LownBertrand GrazFrontiers Media S.A.articletype 2 diabetes mellitusphytomedicinesmedicinal plantsherbal preparationsmetaanalysisrandomised controlled clinical trialsTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	type 2 diabetes mellitus phytomedicines medicinal plants herbal preparations metaanalysis randomised controlled clinical trials Therapeutics. Pharmacology RM1-950
spellingShingle	type 2 diabetes mellitus phytomedicines medicinal plants herbal preparations metaanalysis randomised controlled clinical trials Therapeutics. Pharmacology RM1-950 Merlin L. Willcox Christina Elugbaju Marwah Al-Anbaki Mark Lown Bertrand Graz Effectiveness of Medicinal Plants for Glycaemic Control in Type 2 Diabetes: An Overview of Meta-Analyses of Clinical Trials
description	Aims: To rank the effectiveness of medicinal plants for glycaemic control in Type 2 Diabetes (T2DM).Methods: MEDLINE, EMBASE, CINAHL and Cochrane Central were searched in October 2020. We included meta-analyses of randomised controlled clinical trials measuring the effectiveness of medicinal plants on HbA1c and/or Fasting Plasma Glucose (FPG) in patients with T2DM.Results: Twenty five meta-analyses reported the effects of 18 plant-based remedies. Aloe vera leaf gel, Psyllium fibre and Fenugreek seeds had the largest effects on HbA1c: mean difference –0.99% [95% CI−1.75, −0.23], −0.97% [95% CI −1.94, −0.01] and −0.85% [95% CI −1.49, −0.22] respectively. Four other remedies reduced HbA1c by at least 0.5%: Nigellasativa, Astragalus membranaceus, and the traditional Chinese formulae Jinqi Jiangtang and Gegen Qinlian. No serious adverse effects were reported. Several other herbal medicines significantly reduced FPG. Tea and tea extracts (Camellia sinensis) were ineffective. However, in some trials duration of follow-up was insufficient to measure the full effect on HbA1c (<8 weeks). Many herbal remedies had not been evaluated in a meta-analysis.Conclusion: Several medicinal plants appear to be as effective as conventional antidiabetic treatments for reducing HbA1c. Rigorous trials with at least 3 months’ follow-up are needed to ascertain the effects of promising plant-based preparations on diabetes.
format	article
author	Merlin L. Willcox Christina Elugbaju Marwah Al-Anbaki Mark Lown Bertrand Graz
author_facet	Merlin L. Willcox Christina Elugbaju Marwah Al-Anbaki Mark Lown Bertrand Graz
author_sort	Merlin L. Willcox
title	Effectiveness of Medicinal Plants for Glycaemic Control in Type 2 Diabetes: An Overview of Meta-Analyses of Clinical Trials
title_short	Effectiveness of Medicinal Plants for Glycaemic Control in Type 2 Diabetes: An Overview of Meta-Analyses of Clinical Trials
title_full	Effectiveness of Medicinal Plants for Glycaemic Control in Type 2 Diabetes: An Overview of Meta-Analyses of Clinical Trials
title_fullStr	Effectiveness of Medicinal Plants for Glycaemic Control in Type 2 Diabetes: An Overview of Meta-Analyses of Clinical Trials
title_full_unstemmed	Effectiveness of Medicinal Plants for Glycaemic Control in Type 2 Diabetes: An Overview of Meta-Analyses of Clinical Trials
title_sort	effectiveness of medicinal plants for glycaemic control in type 2 diabetes: an overview of meta-analyses of clinical trials
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/fe153d293c0444f49e9e1513cd09841f
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Effectiveness of Medicinal Plants for Glycaemic Control in Type 2 Diabetes: An Overview of Meta-Analyses of Clinical Trials

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