Mechanism of genome instability mediated by human DNA polymerase mu misincorporation

Mechanism of genome instability mediated by human DNA polymerase mu misincorporation

Pol μ performs gap-filling repair synthesis in the nonhomologous end joining (NHEJ) pathway. Here the authors provide crystal structures and kinetics of human Pol μ to reveal insights into the molecular mechanism of Pol μ during the process of dGTP misincorporation.

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Autores principales: Miao Guo, Yina Wang, Yuyue Tang, Zijing Chen, Jinfeng Hou, Jingli Dai, Yudong Wang, Liangyan Wang, Hong Xu, Bing Tian, Yuejin Hua, Ye Zhao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/fe1a251bc9b3460f8ab99e0438836f6a
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spelling oai:doaj.org-article:fe1a251bc9b3460f8ab99e0438836f6a2021-12-02T17:40:27ZMechanism of genome instability mediated by human DNA polymerase mu misincorporation10.1038/s41467-021-24096-72041-1723https://doaj.org/article/fe1a251bc9b3460f8ab99e0438836f6a2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24096-7https://doaj.org/toc/2041-1723Pol μ performs gap-filling repair synthesis in the nonhomologous end joining (NHEJ) pathway. Here the authors provide crystal structures and kinetics of human Pol μ to reveal insights into the molecular mechanism of Pol μ during the process of dGTP misincorporation.Miao GuoYina WangYuyue TangZijing ChenJinfeng HouJingli DaiYudong WangLiangyan WangHong XuBing TianYuejin HuaYe ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Miao Guo
Yina Wang
Yuyue Tang
Zijing Chen
Jinfeng Hou
Jingli Dai
Yudong Wang
Liangyan Wang
Hong Xu
Bing Tian
Yuejin Hua
Ye Zhao
Mechanism of genome instability mediated by human DNA polymerase mu misincorporation
description Pol μ performs gap-filling repair synthesis in the nonhomologous end joining (NHEJ) pathway. Here the authors provide crystal structures and kinetics of human Pol μ to reveal insights into the molecular mechanism of Pol μ during the process of dGTP misincorporation.
format article
author Miao Guo
Yina Wang
Yuyue Tang
Zijing Chen
Jinfeng Hou
Jingli Dai
Yudong Wang
Liangyan Wang
Hong Xu
Bing Tian
Yuejin Hua
Ye Zhao
author_facet Miao Guo
Yina Wang
Yuyue Tang
Zijing Chen
Jinfeng Hou
Jingli Dai
Yudong Wang
Liangyan Wang
Hong Xu
Bing Tian
Yuejin Hua
Ye Zhao
author_sort Miao Guo
title Mechanism of genome instability mediated by human DNA polymerase mu misincorporation
title_short Mechanism of genome instability mediated by human DNA polymerase mu misincorporation
title_full Mechanism of genome instability mediated by human DNA polymerase mu misincorporation
title_fullStr Mechanism of genome instability mediated by human DNA polymerase mu misincorporation
title_full_unstemmed Mechanism of genome instability mediated by human DNA polymerase mu misincorporation
title_sort mechanism of genome instability mediated by human dna polymerase mu misincorporation
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/fe1a251bc9b3460f8ab99e0438836f6a
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