Perspectives in the Cell-Based Therapies of Various Aspects of the Spinal Cord Injury-Associated Pathologies: Lessons from the Animal Models

Traumatic injury of the spinal cord (SCI) is a devastating neurological condition often leading to severe dysfunctions, therefore an improvement in clinical treatment for SCI patients is urgently needed. The potential benefits of transplantation of various cell types into the injured spinal cord hav...

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Autores principales:	Małgorzata Zawadzka, Anna Kwaśniewska, Krzysztof Miazga, Urszula Sławińska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	spinal cord injury cell transplantation cell-based therapy regeneration Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/fe1f687d943244a9a85a17bac98e3a83
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spelling	oai:doaj.org-article:fe1f687d943244a9a85a17bac98e3a832021-11-25T17:10:12ZPerspectives in the Cell-Based Therapies of Various Aspects of the Spinal Cord Injury-Associated Pathologies: Lessons from the Animal Models10.3390/cells101129952073-4409https://doaj.org/article/fe1f687d943244a9a85a17bac98e3a832021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2995https://doaj.org/toc/2073-4409Traumatic injury of the spinal cord (SCI) is a devastating neurological condition often leading to severe dysfunctions, therefore an improvement in clinical treatment for SCI patients is urgently needed. The potential benefits of transplantation of various cell types into the injured spinal cord have been intensively investigated in preclinical SCI models and clinical trials. Despite the many challenges that are still ahead, cell transplantation alone or in combination with other factors, such as artificial matrices, seems to be the most promising perspective. Here, we reviewed recent advances in cell-based experimental strategies supporting or restoring the function of the injured spinal cord with a particular focus on the regenerative mechanisms that could define their clinical translation.Małgorzata ZawadzkaAnna KwaśniewskaKrzysztof MiazgaUrszula SławińskaMDPI AGarticlespinal cord injurycell transplantationcell-based therapyregenerationBiology (General)QH301-705.5ENCells, Vol 10, Iss 2995, p 2995 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	spinal cord injury cell transplantation cell-based therapy regeneration Biology (General) QH301-705.5
spellingShingle	spinal cord injury cell transplantation cell-based therapy regeneration Biology (General) QH301-705.5 Małgorzata Zawadzka Anna Kwaśniewska Krzysztof Miazga Urszula Sławińska Perspectives in the Cell-Based Therapies of Various Aspects of the Spinal Cord Injury-Associated Pathologies: Lessons from the Animal Models
description	Traumatic injury of the spinal cord (SCI) is a devastating neurological condition often leading to severe dysfunctions, therefore an improvement in clinical treatment for SCI patients is urgently needed. The potential benefits of transplantation of various cell types into the injured spinal cord have been intensively investigated in preclinical SCI models and clinical trials. Despite the many challenges that are still ahead, cell transplantation alone or in combination with other factors, such as artificial matrices, seems to be the most promising perspective. Here, we reviewed recent advances in cell-based experimental strategies supporting or restoring the function of the injured spinal cord with a particular focus on the regenerative mechanisms that could define their clinical translation.
format	article
author	Małgorzata Zawadzka Anna Kwaśniewska Krzysztof Miazga Urszula Sławińska
author_facet	Małgorzata Zawadzka Anna Kwaśniewska Krzysztof Miazga Urszula Sławińska
author_sort	Małgorzata Zawadzka
title	Perspectives in the Cell-Based Therapies of Various Aspects of the Spinal Cord Injury-Associated Pathologies: Lessons from the Animal Models
title_short	Perspectives in the Cell-Based Therapies of Various Aspects of the Spinal Cord Injury-Associated Pathologies: Lessons from the Animal Models
title_full	Perspectives in the Cell-Based Therapies of Various Aspects of the Spinal Cord Injury-Associated Pathologies: Lessons from the Animal Models
title_fullStr	Perspectives in the Cell-Based Therapies of Various Aspects of the Spinal Cord Injury-Associated Pathologies: Lessons from the Animal Models
title_full_unstemmed	Perspectives in the Cell-Based Therapies of Various Aspects of the Spinal Cord Injury-Associated Pathologies: Lessons from the Animal Models
title_sort	perspectives in the cell-based therapies of various aspects of the spinal cord injury-associated pathologies: lessons from the animal models
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fe1f687d943244a9a85a17bac98e3a83
work_keys_str_mv	AT małgorzatazawadzka perspectivesinthecellbasedtherapiesofvariousaspectsofthespinalcordinjuryassociatedpathologieslessonsfromtheanimalmodels AT annakwasniewska perspectivesinthecellbasedtherapiesofvariousaspectsofthespinalcordinjuryassociatedpathologieslessonsfromtheanimalmodels AT krzysztofmiazga perspectivesinthecellbasedtherapiesofvariousaspectsofthespinalcordinjuryassociatedpathologieslessonsfromtheanimalmodels AT urszulasławinska perspectivesinthecellbasedtherapiesofvariousaspectsofthespinalcordinjuryassociatedpathologieslessonsfromtheanimalmodels
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Perspectives in the Cell-Based Therapies of Various Aspects of the Spinal Cord Injury-Associated Pathologies: Lessons from the Animal Models

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