High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.

<h4>Aims/hypothesis</h4>Islet amyloid polypeptide (IAPP) is a beta cell hormone secreted together with insulin upon glucose stimulation. IAPP participates in normal glucose regulation, but IAPP is also known for its ability to misfold and form islet amyloid. Amyloid fibrils form through...

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Autores principales:	Johan F Paulsson, Johnny Ludvigsson, Annelie Carlsson, Rosaura Casas, Gun Forsander, Sten A Ivarsson, Ingrid Kockum, Åke Lernmark, Claude Marcus, Bengt Lindblad, Gunilla T Westermark
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fe2016a67c664464a2a995edd28a451e
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spelling	oai:doaj.org-article:fe2016a67c664464a2a995edd28a451e2021-11-18T08:26:05ZHigh plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.1932-620310.1371/journal.pone.0093053https://doaj.org/article/fe2016a67c664464a2a995edd28a451e2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24671002/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Aims/hypothesis</h4>Islet amyloid polypeptide (IAPP) is a beta cell hormone secreted together with insulin upon glucose stimulation. IAPP participates in normal glucose regulation, but IAPP is also known for its ability to misfold and form islet amyloid. Amyloid fibrils form through smaller cell toxic intermediates and deposited amyloid disrupts normal islet architecture. Even though IAPP and amyloid formation are much discussed in type 2 diabetes, our aim was to study the significance of IAPP in type 1 diabetes.<h4>Results</h4>Plasma IAPP levels in children and adolescents with newly diagnosed type 1 diabetes (n = 224) were analysed and concentrations exceeding 100 pmol/L (127.2-888.7 pmol/L) were found in 11% (25/224). The IAPP increase did not correlate with C-peptide levels.<h4>Conclusions/interpretation</h4>Plasma levels of IAPP and insulin deviate in a subpopulation of young with newly-diagnosed type 1 diabetes. The determined elevated levels of IAPP might increase the risk for IAPP misfolding and formation of cell toxic amyloid in beta cells. This finding add IAPP-aggregation to the list over putative pathological factors causing type 1 diabetes.Johan F PaulssonJohnny LudvigssonAnnelie CarlssonRosaura CasasGun ForsanderSten A IvarssonIngrid KockumÅke LernmarkClaude MarcusBengt LindbladGunilla T WestermarkPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e93053 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Johan F Paulsson Johnny Ludvigsson Annelie Carlsson Rosaura Casas Gun Forsander Sten A Ivarsson Ingrid Kockum Åke Lernmark Claude Marcus Bengt Lindblad Gunilla T Westermark High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.
description	<h4>Aims/hypothesis</h4>Islet amyloid polypeptide (IAPP) is a beta cell hormone secreted together with insulin upon glucose stimulation. IAPP participates in normal glucose regulation, but IAPP is also known for its ability to misfold and form islet amyloid. Amyloid fibrils form through smaller cell toxic intermediates and deposited amyloid disrupts normal islet architecture. Even though IAPP and amyloid formation are much discussed in type 2 diabetes, our aim was to study the significance of IAPP in type 1 diabetes.<h4>Results</h4>Plasma IAPP levels in children and adolescents with newly diagnosed type 1 diabetes (n = 224) were analysed and concentrations exceeding 100 pmol/L (127.2-888.7 pmol/L) were found in 11% (25/224). The IAPP increase did not correlate with C-peptide levels.<h4>Conclusions/interpretation</h4>Plasma levels of IAPP and insulin deviate in a subpopulation of young with newly-diagnosed type 1 diabetes. The determined elevated levels of IAPP might increase the risk for IAPP misfolding and formation of cell toxic amyloid in beta cells. This finding add IAPP-aggregation to the list over putative pathological factors causing type 1 diabetes.
format	article
author	Johan F Paulsson Johnny Ludvigsson Annelie Carlsson Rosaura Casas Gun Forsander Sten A Ivarsson Ingrid Kockum Åke Lernmark Claude Marcus Bengt Lindblad Gunilla T Westermark
author_facet	Johan F Paulsson Johnny Ludvigsson Annelie Carlsson Rosaura Casas Gun Forsander Sten A Ivarsson Ingrid Kockum Åke Lernmark Claude Marcus Bengt Lindblad Gunilla T Westermark
author_sort	Johan F Paulsson
title	High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.
title_short	High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.
title_full	High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.
title_fullStr	High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.
title_full_unstemmed	High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.
title_sort	high plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/fe2016a67c664464a2a995edd28a451e
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High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.

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