Heart rate and risk of cancer death in healthy men.

<h4>Background</h4>Data from several previous studies examining heart-rate and cardiovascular risk have hinted at a possible relationship between heart-rate and non-cardiac mortality. We thus systematically examined the predictive value of heart-rate variables on the subsequent risk of d...

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Autores principales:	Xavier Jouven, Sylvie Escolano, David Celermajer, Jean-Philippe Empana, Annie Bingham, Olivier Hermine, Michel Desnos, Marie-Cécile Perier, Eloi Marijon, Pierre Ducimetière
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fe21d4569ff343daae7ecb576473e567
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spelling	oai:doaj.org-article:fe21d4569ff343daae7ecb576473e5672021-11-18T06:48:49ZHeart rate and risk of cancer death in healthy men.1932-620310.1371/journal.pone.0021310https://doaj.org/article/fe21d4569ff343daae7ecb576473e5672011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21826196/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Data from several previous studies examining heart-rate and cardiovascular risk have hinted at a possible relationship between heart-rate and non-cardiac mortality. We thus systematically examined the predictive value of heart-rate variables on the subsequent risk of death from cancer.<h4>Methods</h4>In the Paris Prospective Study I, 6101 asymptomatic French working men aged 42 to 53 years, free of clinically detectable cardiovascular disease and cancer, underwent a standardized graded exercise test between 1967 and 1972. Resting heart-rate, heart-rate increase during exercise, and decrease during recovery were measured. Change in resting heart-rate over 5 years was also available in 5139 men. Mortality including 758 cancer deaths was assessed over the 25 years of follow-up.<h4>Findings</h4>There were strong, graded and significant relationships between all heart-rate parameters and subsequent cancer deaths. After adjustment for age and tobacco consumption and, compared with the lowest quartile, those with the highest quartile for resting heart-rate had a relative risk of 2.4 for cancer deaths (95% confidence interval: 1.9-2.9, p<0.0001) This was similar after adjustment for traditional cardiovascular risk factors and was observed for the commonest malignancies (respiratory and gastrointestinal). Similarly, significant relationships with cancer death were observed between poor heart rate increase during exercise, poor decrease during recovery and greater heart-rate increase over time (p<0.0001 for all).<h4>Interpretation</h4>Resting and exercise heart rate had consistent, graded and highly significant associations with subsequent cancer mortality in men.Xavier JouvenSylvie EscolanoDavid CelermajerJean-Philippe EmpanaAnnie BinghamOlivier HermineMichel DesnosMarie-Cécile PerierEloi MarijonPierre DucimetièrePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 8, p e21310 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xavier Jouven Sylvie Escolano David Celermajer Jean-Philippe Empana Annie Bingham Olivier Hermine Michel Desnos Marie-Cécile Perier Eloi Marijon Pierre Ducimetière Heart rate and risk of cancer death in healthy men.
description	<h4>Background</h4>Data from several previous studies examining heart-rate and cardiovascular risk have hinted at a possible relationship between heart-rate and non-cardiac mortality. We thus systematically examined the predictive value of heart-rate variables on the subsequent risk of death from cancer.<h4>Methods</h4>In the Paris Prospective Study I, 6101 asymptomatic French working men aged 42 to 53 years, free of clinically detectable cardiovascular disease and cancer, underwent a standardized graded exercise test between 1967 and 1972. Resting heart-rate, heart-rate increase during exercise, and decrease during recovery were measured. Change in resting heart-rate over 5 years was also available in 5139 men. Mortality including 758 cancer deaths was assessed over the 25 years of follow-up.<h4>Findings</h4>There were strong, graded and significant relationships between all heart-rate parameters and subsequent cancer deaths. After adjustment for age and tobacco consumption and, compared with the lowest quartile, those with the highest quartile for resting heart-rate had a relative risk of 2.4 for cancer deaths (95% confidence interval: 1.9-2.9, p<0.0001) This was similar after adjustment for traditional cardiovascular risk factors and was observed for the commonest malignancies (respiratory and gastrointestinal). Similarly, significant relationships with cancer death were observed between poor heart rate increase during exercise, poor decrease during recovery and greater heart-rate increase over time (p<0.0001 for all).<h4>Interpretation</h4>Resting and exercise heart rate had consistent, graded and highly significant associations with subsequent cancer mortality in men.
format	article
author	Xavier Jouven Sylvie Escolano David Celermajer Jean-Philippe Empana Annie Bingham Olivier Hermine Michel Desnos Marie-Cécile Perier Eloi Marijon Pierre Ducimetière
author_facet	Xavier Jouven Sylvie Escolano David Celermajer Jean-Philippe Empana Annie Bingham Olivier Hermine Michel Desnos Marie-Cécile Perier Eloi Marijon Pierre Ducimetière
author_sort	Xavier Jouven
title	Heart rate and risk of cancer death in healthy men.
title_short	Heart rate and risk of cancer death in healthy men.
title_full	Heart rate and risk of cancer death in healthy men.
title_fullStr	Heart rate and risk of cancer death in healthy men.
title_full_unstemmed	Heart rate and risk of cancer death in healthy men.
title_sort	heart rate and risk of cancer death in healthy men.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/fe21d4569ff343daae7ecb576473e567
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Heart rate and risk of cancer death in healthy men.

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