Heart rate and risk of cancer death in healthy men.

<h4>Background</h4>Data from several previous studies examining heart-rate and cardiovascular risk have hinted at a possible relationship between heart-rate and non-cardiac mortality. We thus systematically examined the predictive value of heart-rate variables on the subsequent risk of d...

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Autores principales: Xavier Jouven, Sylvie Escolano, David Celermajer, Jean-Philippe Empana, Annie Bingham, Olivier Hermine, Michel Desnos, Marie-Cécile Perier, Eloi Marijon, Pierre Ducimetière
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Publicado: Public Library of Science (PLoS) 2011
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spelling oai:doaj.org-article:fe21d4569ff343daae7ecb576473e5672021-11-18T06:48:49ZHeart rate and risk of cancer death in healthy men.1932-620310.1371/journal.pone.0021310https://doaj.org/article/fe21d4569ff343daae7ecb576473e5672011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21826196/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Data from several previous studies examining heart-rate and cardiovascular risk have hinted at a possible relationship between heart-rate and non-cardiac mortality. We thus systematically examined the predictive value of heart-rate variables on the subsequent risk of death from cancer.<h4>Methods</h4>In the Paris Prospective Study I, 6101 asymptomatic French working men aged 42 to 53 years, free of clinically detectable cardiovascular disease and cancer, underwent a standardized graded exercise test between 1967 and 1972. Resting heart-rate, heart-rate increase during exercise, and decrease during recovery were measured. Change in resting heart-rate over 5 years was also available in 5139 men. Mortality including 758 cancer deaths was assessed over the 25 years of follow-up.<h4>Findings</h4>There were strong, graded and significant relationships between all heart-rate parameters and subsequent cancer deaths. After adjustment for age and tobacco consumption and, compared with the lowest quartile, those with the highest quartile for resting heart-rate had a relative risk of 2.4 for cancer deaths (95% confidence interval: 1.9-2.9, p<0.0001) This was similar after adjustment for traditional cardiovascular risk factors and was observed for the commonest malignancies (respiratory and gastrointestinal). Similarly, significant relationships with cancer death were observed between poor heart rate increase during exercise, poor decrease during recovery and greater heart-rate increase over time (p<0.0001 for all).<h4>Interpretation</h4>Resting and exercise heart rate had consistent, graded and highly significant associations with subsequent cancer mortality in men.Xavier JouvenSylvie EscolanoDavid CelermajerJean-Philippe EmpanaAnnie BinghamOlivier HermineMichel DesnosMarie-Cécile PerierEloi MarijonPierre DucimetièrePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 8, p e21310 (2011)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Xavier Jouven
Sylvie Escolano
David Celermajer
Jean-Philippe Empana
Annie Bingham
Olivier Hermine
Michel Desnos
Marie-Cécile Perier
Eloi Marijon
Pierre Ducimetière
Heart rate and risk of cancer death in healthy men.
description <h4>Background</h4>Data from several previous studies examining heart-rate and cardiovascular risk have hinted at a possible relationship between heart-rate and non-cardiac mortality. We thus systematically examined the predictive value of heart-rate variables on the subsequent risk of death from cancer.<h4>Methods</h4>In the Paris Prospective Study I, 6101 asymptomatic French working men aged 42 to 53 years, free of clinically detectable cardiovascular disease and cancer, underwent a standardized graded exercise test between 1967 and 1972. Resting heart-rate, heart-rate increase during exercise, and decrease during recovery were measured. Change in resting heart-rate over 5 years was also available in 5139 men. Mortality including 758 cancer deaths was assessed over the 25 years of follow-up.<h4>Findings</h4>There were strong, graded and significant relationships between all heart-rate parameters and subsequent cancer deaths. After adjustment for age and tobacco consumption and, compared with the lowest quartile, those with the highest quartile for resting heart-rate had a relative risk of 2.4 for cancer deaths (95% confidence interval: 1.9-2.9, p<0.0001) This was similar after adjustment for traditional cardiovascular risk factors and was observed for the commonest malignancies (respiratory and gastrointestinal). Similarly, significant relationships with cancer death were observed between poor heart rate increase during exercise, poor decrease during recovery and greater heart-rate increase over time (p<0.0001 for all).<h4>Interpretation</h4>Resting and exercise heart rate had consistent, graded and highly significant associations with subsequent cancer mortality in men.
format article
author Xavier Jouven
Sylvie Escolano
David Celermajer
Jean-Philippe Empana
Annie Bingham
Olivier Hermine
Michel Desnos
Marie-Cécile Perier
Eloi Marijon
Pierre Ducimetière
author_facet Xavier Jouven
Sylvie Escolano
David Celermajer
Jean-Philippe Empana
Annie Bingham
Olivier Hermine
Michel Desnos
Marie-Cécile Perier
Eloi Marijon
Pierre Ducimetière
author_sort Xavier Jouven
title Heart rate and risk of cancer death in healthy men.
title_short Heart rate and risk of cancer death in healthy men.
title_full Heart rate and risk of cancer death in healthy men.
title_fullStr Heart rate and risk of cancer death in healthy men.
title_full_unstemmed Heart rate and risk of cancer death in healthy men.
title_sort heart rate and risk of cancer death in healthy men.
publisher Public Library of Science (PLoS)
publishDate 2011
url https://doaj.org/article/fe21d4569ff343daae7ecb576473e567
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