Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors

Some exercises exacerbate chronic inflammation and muscle fibrosis in chronic myopathy. Here, the authors show that senescence of fibro-adipogenic progenitors (FAPs) in response to exercise induces muscle regeneration, and impaired FAP senescence worsens inflammation and fibrosis in chronic myopathy...

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Autores principales:	Yuki Saito, Takako S. Chikenji, Takashi Matsumura, Masako Nakano, Mineko Fujimiya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fe22f40a09fa49bab5d41e152ac31ada
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spelling	oai:doaj.org-article:fe22f40a09fa49bab5d41e152ac31ada2021-12-02T14:40:38ZExercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors10.1038/s41467-020-14734-x2041-1723https://doaj.org/article/fe22f40a09fa49bab5d41e152ac31ada2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14734-xhttps://doaj.org/toc/2041-1723Some exercises exacerbate chronic inflammation and muscle fibrosis in chronic myopathy. Here, the authors show that senescence of fibro-adipogenic progenitors (FAPs) in response to exercise induces muscle regeneration, and impaired FAP senescence worsens inflammation and fibrosis in chronic myopathy in mice.Yuki SaitoTakako S. ChikenjiTakashi MatsumuraMasako NakanoMineko FujimiyaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuki Saito Takako S. Chikenji Takashi Matsumura Masako Nakano Mineko Fujimiya Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors
description	Some exercises exacerbate chronic inflammation and muscle fibrosis in chronic myopathy. Here, the authors show that senescence of fibro-adipogenic progenitors (FAPs) in response to exercise induces muscle regeneration, and impaired FAP senescence worsens inflammation and fibrosis in chronic myopathy in mice.
format	article
author	Yuki Saito Takako S. Chikenji Takashi Matsumura Masako Nakano Mineko Fujimiya
author_facet	Yuki Saito Takako S. Chikenji Takashi Matsumura Masako Nakano Mineko Fujimiya
author_sort	Yuki Saito
title	Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors
title_short	Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors
title_full	Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors
title_fullStr	Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors
title_full_unstemmed	Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors
title_sort	exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fe22f40a09fa49bab5d41e152ac31ada
work_keys_str_mv	AT yukisaito exerciseenhancesskeletalmuscleregenerationbypromotingsenescenceinfibroadipogenicprogenitors AT takakoschikenji exerciseenhancesskeletalmuscleregenerationbypromotingsenescenceinfibroadipogenicprogenitors AT takashimatsumura exerciseenhancesskeletalmuscleregenerationbypromotingsenescenceinfibroadipogenicprogenitors AT masakonakano exerciseenhancesskeletalmuscleregenerationbypromotingsenescenceinfibroadipogenicprogenitors AT minekofujimiya exerciseenhancesskeletalmuscleregenerationbypromotingsenescenceinfibroadipogenicprogenitors
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Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors

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