Integrative analysis of the choroid by quantifying Haller vessel and choriocapillaris parameters in different drusen subtypes

Abstract This study aimed to quantify the Haller vessel and choriocapillaris (CC) parameters in drusen subtypes in nonexudative age-related macular degeneration (AMD) and pachydrusen. Ninety-five eyes of 80 patients and 28 control eyes were categorized into soft drusen, subretinal drusenoid deposit...

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Autores principales:	Hyungwoo Lee, Seungmin Kim, Myung Ae Kim, Young Joon Jo, Woo Hyuk Lee, Hyung Chan Kim, Hyewon Chung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fe2408b21d87457b8a1aa85f6681a521
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spelling	oai:doaj.org-article:fe2408b21d87457b8a1aa85f6681a5212021-12-02T16:24:53ZIntegrative analysis of the choroid by quantifying Haller vessel and choriocapillaris parameters in different drusen subtypes10.1038/s41598-021-94627-12045-2322https://doaj.org/article/fe2408b21d87457b8a1aa85f6681a5212021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94627-1https://doaj.org/toc/2045-2322Abstract This study aimed to quantify the Haller vessel and choriocapillaris (CC) parameters in drusen subtypes in nonexudative age-related macular degeneration (AMD) and pachydrusen. Ninety-five eyes of 80 patients and 28 control eyes were categorized into soft drusen, subretinal drusenoid deposit (SDD), soft drusen plus SDD, pachydrusen, and control groups. The diameter, length and intersections of Haller vessels and the total area, size and number of CC flow voids were quantified using en face optical coherence tomography (OCT) or OCT angiography. The pachydrusen group showed the largest Haller vessel area and diameter and shortest total length but similar CC parameters to those in the control group. The soft drusen plus SDD group showed the largest CC flow void area and size, while the Haller parameters were similar to those in the control group. The area and size of the flow voids in the SDD group were smaller than those in the soft drusen plus SDD group. Based on unsupervised machine learning, the eyes were classified into 4 clusters—the control, pachydrusen, soft drusen plus SDD and soft drusen plus SDD groups. Cluster 3 showed a larger diameter and shorter total length of the Haller vessels than cluster 4.Hyungwoo LeeSeungmin KimMyung Ae KimYoung Joon JoWoo Hyuk LeeHyung Chan KimHyewon ChungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyungwoo Lee Seungmin Kim Myung Ae Kim Young Joon Jo Woo Hyuk Lee Hyung Chan Kim Hyewon Chung Integrative analysis of the choroid by quantifying Haller vessel and choriocapillaris parameters in different drusen subtypes
description	Abstract This study aimed to quantify the Haller vessel and choriocapillaris (CC) parameters in drusen subtypes in nonexudative age-related macular degeneration (AMD) and pachydrusen. Ninety-five eyes of 80 patients and 28 control eyes were categorized into soft drusen, subretinal drusenoid deposit (SDD), soft drusen plus SDD, pachydrusen, and control groups. The diameter, length and intersections of Haller vessels and the total area, size and number of CC flow voids were quantified using en face optical coherence tomography (OCT) or OCT angiography. The pachydrusen group showed the largest Haller vessel area and diameter and shortest total length but similar CC parameters to those in the control group. The soft drusen plus SDD group showed the largest CC flow void area and size, while the Haller parameters were similar to those in the control group. The area and size of the flow voids in the SDD group were smaller than those in the soft drusen plus SDD group. Based on unsupervised machine learning, the eyes were classified into 4 clusters—the control, pachydrusen, soft drusen plus SDD and soft drusen plus SDD groups. Cluster 3 showed a larger diameter and shorter total length of the Haller vessels than cluster 4.
format	article
author	Hyungwoo Lee Seungmin Kim Myung Ae Kim Young Joon Jo Woo Hyuk Lee Hyung Chan Kim Hyewon Chung
author_facet	Hyungwoo Lee Seungmin Kim Myung Ae Kim Young Joon Jo Woo Hyuk Lee Hyung Chan Kim Hyewon Chung
author_sort	Hyungwoo Lee
title	Integrative analysis of the choroid by quantifying Haller vessel and choriocapillaris parameters in different drusen subtypes
title_short	Integrative analysis of the choroid by quantifying Haller vessel and choriocapillaris parameters in different drusen subtypes
title_full	Integrative analysis of the choroid by quantifying Haller vessel and choriocapillaris parameters in different drusen subtypes
title_fullStr	Integrative analysis of the choroid by quantifying Haller vessel and choriocapillaris parameters in different drusen subtypes
title_full_unstemmed	Integrative analysis of the choroid by quantifying Haller vessel and choriocapillaris parameters in different drusen subtypes
title_sort	integrative analysis of the choroid by quantifying haller vessel and choriocapillaris parameters in different drusen subtypes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fe2408b21d87457b8a1aa85f6681a521
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Integrative analysis of the choroid by quantifying Haller vessel and choriocapillaris parameters in different drusen subtypes

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