The prognostic effects of somatic mutations in ER-positive breast cancer
Unravelling the link between somatic mutation and prognosis in estrogen positive (ER+) breast cancer requires the use of long-term follow-up data. Here, combining archival formalin-fixed paraffin embedded tissue and targeted sequencing in three cohorts of ER+ breast cancer, the authors find associat...
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Nature Portfolio
2018
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oai:doaj.org-article:fe27abc720eb4d50bc7f128d4b6ad4902021-12-02T15:34:21ZThe prognostic effects of somatic mutations in ER-positive breast cancer10.1038/s41467-018-05914-x2041-1723https://doaj.org/article/fe27abc720eb4d50bc7f128d4b6ad4902018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05914-xhttps://doaj.org/toc/2041-1723Unravelling the link between somatic mutation and prognosis in estrogen positive (ER+) breast cancer requires the use of long-term follow-up data. Here, combining archival formalin-fixed paraffin embedded tissue and targeted sequencing in three cohorts of ER+ breast cancer, the authors find associations with clinical outcome for NF1 frame-shift nonsense mutations, PIK3R1 mutation, and DDR1 mutations.Obi L. GriffithNicholas C. SpiesMeenakshi AnuragMalachi GriffithJingqin LuoDongsheng TuBelinda YeoJason KunisakiChristopher A MillerKilannin KrysiakJasreet HundalBenjamin J AinscoughZachary L. SkidmoreKatie CampbellRunjun KumarCatrina FronickLisa CookJacqueline E. SniderSherri DaviesShyam M. KavuriEric C. ChangVincent MagriniDavid E. LarsonRobert S FultonShuzhen LiuSamuel LeungDavid VoducRon BoseMitch DowsettRichard K. WilsonTorsten O. NielsenElaine R MardisMatthew J. EllisNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018) |
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Science Q Obi L. Griffith Nicholas C. Spies Meenakshi Anurag Malachi Griffith Jingqin Luo Dongsheng Tu Belinda Yeo Jason Kunisaki Christopher A Miller Kilannin Krysiak Jasreet Hundal Benjamin J Ainscough Zachary L. Skidmore Katie Campbell Runjun Kumar Catrina Fronick Lisa Cook Jacqueline E. Snider Sherri Davies Shyam M. Kavuri Eric C. Chang Vincent Magrini David E. Larson Robert S Fulton Shuzhen Liu Samuel Leung David Voduc Ron Bose Mitch Dowsett Richard K. Wilson Torsten O. Nielsen Elaine R Mardis Matthew J. Ellis The prognostic effects of somatic mutations in ER-positive breast cancer |
| description |
Unravelling the link between somatic mutation and prognosis in estrogen positive (ER+) breast cancer requires the use of long-term follow-up data. Here, combining archival formalin-fixed paraffin embedded tissue and targeted sequencing in three cohorts of ER+ breast cancer, the authors find associations with clinical outcome for NF1 frame-shift nonsense mutations, PIK3R1 mutation, and DDR1 mutations. |
| format |
article |
| author |
Obi L. Griffith Nicholas C. Spies Meenakshi Anurag Malachi Griffith Jingqin Luo Dongsheng Tu Belinda Yeo Jason Kunisaki Christopher A Miller Kilannin Krysiak Jasreet Hundal Benjamin J Ainscough Zachary L. Skidmore Katie Campbell Runjun Kumar Catrina Fronick Lisa Cook Jacqueline E. Snider Sherri Davies Shyam M. Kavuri Eric C. Chang Vincent Magrini David E. Larson Robert S Fulton Shuzhen Liu Samuel Leung David Voduc Ron Bose Mitch Dowsett Richard K. Wilson Torsten O. Nielsen Elaine R Mardis Matthew J. Ellis |
| author_facet |
Obi L. Griffith Nicholas C. Spies Meenakshi Anurag Malachi Griffith Jingqin Luo Dongsheng Tu Belinda Yeo Jason Kunisaki Christopher A Miller Kilannin Krysiak Jasreet Hundal Benjamin J Ainscough Zachary L. Skidmore Katie Campbell Runjun Kumar Catrina Fronick Lisa Cook Jacqueline E. Snider Sherri Davies Shyam M. Kavuri Eric C. Chang Vincent Magrini David E. Larson Robert S Fulton Shuzhen Liu Samuel Leung David Voduc Ron Bose Mitch Dowsett Richard K. Wilson Torsten O. Nielsen Elaine R Mardis Matthew J. Ellis |
| author_sort |
Obi L. Griffith |
| title |
The prognostic effects of somatic mutations in ER-positive breast cancer |
| title_short |
The prognostic effects of somatic mutations in ER-positive breast cancer |
| title_full |
The prognostic effects of somatic mutations in ER-positive breast cancer |
| title_fullStr |
The prognostic effects of somatic mutations in ER-positive breast cancer |
| title_full_unstemmed |
The prognostic effects of somatic mutations in ER-positive breast cancer |
| title_sort |
prognostic effects of somatic mutations in er-positive breast cancer |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/fe27abc720eb4d50bc7f128d4b6ad490 |
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