Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome

Altered dosage of developmental regulators such as transcription factors can result in disorders, such as FOXG1 syndrome. Here, the authors demonstrate the utility of SMASh technology for modulating protein dosage by modeling FOXG1 syndrome using human pluripotent stem cell-derived neurons and neura...

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Autores principales:	Wenliang Zhu, Boya Zhang, Mengqi Li, Fan Mo, Tingwei Mi, Yihui Wu, Zhaoqian Teng, Qi Zhou, Wei Li, Baoyang Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fe289d2c0c864031a37e09fb8593c020
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:fe289d2c0c864031a37e09fb8593c0202021-12-02T16:58:06ZPrecisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome10.1038/s41467-019-08841-72041-1723https://doaj.org/article/fe289d2c0c864031a37e09fb8593c0202019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08841-7https://doaj.org/toc/2041-1723Altered dosage of developmental regulators such as transcription factors can result in disorders, such as FOXG1 syndrome. Here, the authors demonstrate the utility of SMASh technology for modulating protein dosage by modeling FOXG1 syndrome using human pluripotent stem cell-derived neurons and neural organoids.Wenliang ZhuBoya ZhangMengqi LiFan MoTingwei MiYihui WuZhaoqian TengQi ZhouWei LiBaoyang HuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenliang Zhu Boya Zhang Mengqi Li Fan Mo Tingwei Mi Yihui Wu Zhaoqian Teng Qi Zhou Wei Li Baoyang Hu Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome
description	Altered dosage of developmental regulators such as transcription factors can result in disorders, such as FOXG1 syndrome. Here, the authors demonstrate the utility of SMASh technology for modulating protein dosage by modeling FOXG1 syndrome using human pluripotent stem cell-derived neurons and neural organoids.
format	article
author	Wenliang Zhu Boya Zhang Mengqi Li Fan Mo Tingwei Mi Yihui Wu Zhaoqian Teng Qi Zhou Wei Li Baoyang Hu
author_facet	Wenliang Zhu Boya Zhang Mengqi Li Fan Mo Tingwei Mi Yihui Wu Zhaoqian Teng Qi Zhou Wei Li Baoyang Hu
author_sort	Wenliang Zhu
title	Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome
title_short	Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome
title_full	Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome
title_fullStr	Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome
title_full_unstemmed	Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome
title_sort	precisely controlling endogenous protein dosage in hpscs and derivatives to model foxg1 syndrome
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fe289d2c0c864031a37e09fb8593c020
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Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome

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