Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice

Sleep pressure and circadian rhythms influence one another. However, the regulatory mechanisms are unclear. Here, the authors show that adenosine A1/A2A receptor antagonists, such as caffeine, shift circadian rhythms and enhance the effects of light, providing a molecular link between sleep pressure...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Aarti Jagannath, Norbert Varga, Robert Dallmann, Gianpaolo Rando, Pauline Gosselin, Farid Ebrahimjee, Lewis Taylor, Dragos Mosneagu, Jakub Stefaniak, Steven Walsh, Teele Palumaa, Simona Di Pretoro, Harshmeena Sanghani, Zeinab Wakaf, Grant C. Churchill, Antony Galione, Stuart N. Peirson, Detlev Boison, Steven A. Brown, Russell G. Foster, Sridhar R. Vasudevan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fe29a732cf334692a98923abc1d068d8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fe29a732cf334692a98923abc1d068d8
record_format	dspace
spelling	oai:doaj.org-article:fe29a732cf334692a98923abc1d068d82021-12-02T14:37:37ZAdenosine integrates light and sleep signalling for the regulation of circadian timing in mice10.1038/s41467-021-22179-z2041-1723https://doaj.org/article/fe29a732cf334692a98923abc1d068d82021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22179-zhttps://doaj.org/toc/2041-1723Sleep pressure and circadian rhythms influence one another. However, the regulatory mechanisms are unclear. Here, the authors show that adenosine A1/A2A receptor antagonists, such as caffeine, shift circadian rhythms and enhance the effects of light, providing a molecular link between sleep pressure and circadian rhythm.Aarti JagannathNorbert VargaRobert DallmannGianpaolo RandoPauline GosselinFarid EbrahimjeeLewis TaylorDragos MosneaguJakub StefaniakSteven WalshTeele PalumaaSimona Di PretoroHarshmeena SanghaniZeinab WakafGrant C. ChurchillAntony GalioneStuart N. PeirsonDetlev BoisonSteven A. BrownRussell G. FosterSridhar R. VasudevanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aarti Jagannath Norbert Varga Robert Dallmann Gianpaolo Rando Pauline Gosselin Farid Ebrahimjee Lewis Taylor Dragos Mosneagu Jakub Stefaniak Steven Walsh Teele Palumaa Simona Di Pretoro Harshmeena Sanghani Zeinab Wakaf Grant C. Churchill Antony Galione Stuart N. Peirson Detlev Boison Steven A. Brown Russell G. Foster Sridhar R. Vasudevan Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice
description	Sleep pressure and circadian rhythms influence one another. However, the regulatory mechanisms are unclear. Here, the authors show that adenosine A1/A2A receptor antagonists, such as caffeine, shift circadian rhythms and enhance the effects of light, providing a molecular link between sleep pressure and circadian rhythm.
format	article
author	Aarti Jagannath Norbert Varga Robert Dallmann Gianpaolo Rando Pauline Gosselin Farid Ebrahimjee Lewis Taylor Dragos Mosneagu Jakub Stefaniak Steven Walsh Teele Palumaa Simona Di Pretoro Harshmeena Sanghani Zeinab Wakaf Grant C. Churchill Antony Galione Stuart N. Peirson Detlev Boison Steven A. Brown Russell G. Foster Sridhar R. Vasudevan
author_facet	Aarti Jagannath Norbert Varga Robert Dallmann Gianpaolo Rando Pauline Gosselin Farid Ebrahimjee Lewis Taylor Dragos Mosneagu Jakub Stefaniak Steven Walsh Teele Palumaa Simona Di Pretoro Harshmeena Sanghani Zeinab Wakaf Grant C. Churchill Antony Galione Stuart N. Peirson Detlev Boison Steven A. Brown Russell G. Foster Sridhar R. Vasudevan
author_sort	Aarti Jagannath
title	Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice
title_short	Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice
title_full	Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice
title_fullStr	Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice
title_full_unstemmed	Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice
title_sort	adenosine integrates light and sleep signalling for the regulation of circadian timing in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fe29a732cf334692a98923abc1d068d8
work_keys_str_mv	AT aartijagannath adenosineintegrateslightandsleepsignallingfortheregulationofcircadiantiminginmice AT norbertvarga adenosineintegrateslightandsleepsignallingfortheregulationofcircadiantiminginmice AT robertdallmann adenosineintegrateslightandsleepsignallingfortheregulationofcircadiantiminginmice AT gianpaolorando adenosineintegrateslightandsleepsignallingfortheregulationofcircadiantiminginmice AT paulinegosselin adenosineintegrateslightandsleepsignallingfortheregulationofcircadiantiminginmice AT faridebrahimjee adenosineintegrateslightandsleepsignallingfortheregulationofcircadiantiminginmice AT lewistaylor adenosineintegrateslightandsleepsignallingfortheregulationofcircadiantiminginmice AT dragosmosneagu adenosineintegrateslightandsleepsignallingfortheregulationofcircadiantiminginmice AT jakubstefaniak adenosineintegrateslightandsleepsignallingfortheregulationofcircadiantiminginmice AT stevenwalsh adenosineintegrateslightandsleepsignallingfortheregulationofcircadiantiminginmice AT teelepalumaa adenosineintegrateslightandsleepsignallingfortheregulationofcircadiantiminginmice AT simonadipretoro adenosineintegrateslightandsleepsignallingfortheregulationofcircadiantiminginmice AT harshmeenasanghani adenosineintegrateslightandsleepsignallingfortheregulationofcircadiantiminginmice AT zeinabwakaf adenosineintegrateslightandsleepsignallingfortheregulationofcircadiantiminginmice AT grantcchurchill adenosineintegrateslightandsleepsignallingfortheregulationofcircadiantiminginmice AT antonygalione adenosineintegrateslightandsleepsignallingfortheregulationofcircadiantiminginmice AT stuartnpeirson adenosineintegrateslightandsleepsignallingfortheregulationofcircadiantiminginmice AT detlevboison adenosineintegrateslightandsleepsignallingfortheregulationofcircadiantiminginmice AT stevenabrown adenosineintegrateslightandsleepsignallingfortheregulationofcircadiantiminginmice AT russellgfoster adenosineintegrateslightandsleepsignallingfortheregulationofcircadiantiminginmice AT sridharrvasudevan adenosineintegrateslightandsleepsignallingfortheregulationofcircadiantiminginmice
_version_	1718391049889513472

Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice

Ejemplares similares