Prognostic role of microRNA-181a/b in hematological malignancies: a meta-analysis.

<h4>Background</h4>Emerging evidence has shown that miRNAs participate in human carcinogenesis as tumor suppressors or oncogenes, and have prognostic value for patients with cancers. In recent years, the miR-181 family was found dysregulated in a variety of human cancers and significantl...

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Autores principales:	Shenglong Lin, Lili Pan, Shicheng Guo, Junjie Wu, Li Jin, Jiu-Cun Wang, Shaoyuan Wang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fe2cca96f66543cdbb1664dffeb81008
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spelling	oai:doaj.org-article:fe2cca96f66543cdbb1664dffeb810082021-11-18T07:52:16ZPrognostic role of microRNA-181a/b in hematological malignancies: a meta-analysis.1932-620310.1371/journal.pone.0059532https://doaj.org/article/fe2cca96f66543cdbb1664dffeb810082013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23533632/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Emerging evidence has shown that miRNAs participate in human carcinogenesis as tumor suppressors or oncogenes, and have prognostic value for patients with cancers. In recent years, the miR-181 family was found dysregulated in a variety of human cancers and significantly associated with clinical outcome of cancerous patients. MiR-181a and miR-181b (miR-181a/b) were the most investigated members in the family. However, the results of miR-181a/b from different studies were inconsistent. Therefore, we performed a meta-analysis to summarize all the results from available studies, aiming to delineate the prognostic role of miR-181a/b in human cancers.<h4>Methods</h4>The identified articles were retrieved from the two main on-line databases, PubMed and EMBASE. We extracted and estimated the hazard ratios (HRs) for overall survival (OS), which compared the high and low expression levels of miR-181a/b in patients of the available studies. Each individual HR was used to calculate the pooled HR.<h4>Results</h4>Eleven studies of 1252 patients were selected into the final meta-analysis after a strict filtering and qualifying process. Fixed model or random model method was chosen depending on the heterogeneity between the studies. The subgroup analysis showed that high expressed miR-181a/b could prolong OS in patients with hematological malignancies rather than low expression level (HR = 0.717, P<0.0001). But the expression of miR-181a/b was not significantly relative to OS in patients with various cancers (HR = 0.861, p = 0.356).<h4>Conclusion</h4>Our study indicates that the expression level of miR-181a/b is significantly associated with OS in hematological malignancies and can be an important clinical prognostic factor for those patients.Shenglong LinLili PanShicheng GuoJunjie WuLi JinJiu-Cun WangShaoyuan WangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e59532 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shenglong Lin Lili Pan Shicheng Guo Junjie Wu Li Jin Jiu-Cun Wang Shaoyuan Wang Prognostic role of microRNA-181a/b in hematological malignancies: a meta-analysis.
description	<h4>Background</h4>Emerging evidence has shown that miRNAs participate in human carcinogenesis as tumor suppressors or oncogenes, and have prognostic value for patients with cancers. In recent years, the miR-181 family was found dysregulated in a variety of human cancers and significantly associated with clinical outcome of cancerous patients. MiR-181a and miR-181b (miR-181a/b) were the most investigated members in the family. However, the results of miR-181a/b from different studies were inconsistent. Therefore, we performed a meta-analysis to summarize all the results from available studies, aiming to delineate the prognostic role of miR-181a/b in human cancers.<h4>Methods</h4>The identified articles were retrieved from the two main on-line databases, PubMed and EMBASE. We extracted and estimated the hazard ratios (HRs) for overall survival (OS), which compared the high and low expression levels of miR-181a/b in patients of the available studies. Each individual HR was used to calculate the pooled HR.<h4>Results</h4>Eleven studies of 1252 patients were selected into the final meta-analysis after a strict filtering and qualifying process. Fixed model or random model method was chosen depending on the heterogeneity between the studies. The subgroup analysis showed that high expressed miR-181a/b could prolong OS in patients with hematological malignancies rather than low expression level (HR = 0.717, P<0.0001). But the expression of miR-181a/b was not significantly relative to OS in patients with various cancers (HR = 0.861, p = 0.356).<h4>Conclusion</h4>Our study indicates that the expression level of miR-181a/b is significantly associated with OS in hematological malignancies and can be an important clinical prognostic factor for those patients.
format	article
author	Shenglong Lin Lili Pan Shicheng Guo Junjie Wu Li Jin Jiu-Cun Wang Shaoyuan Wang
author_facet	Shenglong Lin Lili Pan Shicheng Guo Junjie Wu Li Jin Jiu-Cun Wang Shaoyuan Wang
author_sort	Shenglong Lin
title	Prognostic role of microRNA-181a/b in hematological malignancies: a meta-analysis.
title_short	Prognostic role of microRNA-181a/b in hematological malignancies: a meta-analysis.
title_full	Prognostic role of microRNA-181a/b in hematological malignancies: a meta-analysis.
title_fullStr	Prognostic role of microRNA-181a/b in hematological malignancies: a meta-analysis.
title_full_unstemmed	Prognostic role of microRNA-181a/b in hematological malignancies: a meta-analysis.
title_sort	prognostic role of microrna-181a/b in hematological malignancies: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/fe2cca96f66543cdbb1664dffeb81008
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Prognostic role of microRNA-181a/b in hematological malignancies: a meta-analysis.

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