ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis

Recombination requires DNA break formation by SPO11, following which SPO11 is thought to be released. Here, the authors show that meiotic hotspots retain SPO11 through a recombination intermediate dependent on the methyltransferase PRDM9, and that the ATM kinase governs the release of SPO11.

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Autores principales:	Jacob Paiano, Wei Wu, Shintaro Yamada, Nicholas Sciascia, Elsa Callen, Ana Paola Cotrim, Rajashree A. Deshpande, Yaakov Maman, Amanda Day, Tanya T. Paull, André Nussenzweig
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fe2f3dab8f70455daf145802e93451d5
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spelling	oai:doaj.org-article:fe2f3dab8f70455daf145802e93451d52021-12-02T14:42:48ZATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis10.1038/s41467-020-14654-w2041-1723https://doaj.org/article/fe2f3dab8f70455daf145802e93451d52020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14654-whttps://doaj.org/toc/2041-1723Recombination requires DNA break formation by SPO11, following which SPO11 is thought to be released. Here, the authors show that meiotic hotspots retain SPO11 through a recombination intermediate dependent on the methyltransferase PRDM9, and that the ATM kinase governs the release of SPO11.Jacob PaianoWei WuShintaro YamadaNicholas SciasciaElsa CallenAna Paola CotrimRajashree A. DeshpandeYaakov MamanAmanda DayTanya T. PaullAndré NussenzweigNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jacob Paiano Wei Wu Shintaro Yamada Nicholas Sciascia Elsa Callen Ana Paola Cotrim Rajashree A. Deshpande Yaakov Maman Amanda Day Tanya T. Paull André Nussenzweig ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis
description	Recombination requires DNA break formation by SPO11, following which SPO11 is thought to be released. Here, the authors show that meiotic hotspots retain SPO11 through a recombination intermediate dependent on the methyltransferase PRDM9, and that the ATM kinase governs the release of SPO11.
format	article
author	Jacob Paiano Wei Wu Shintaro Yamada Nicholas Sciascia Elsa Callen Ana Paola Cotrim Rajashree A. Deshpande Yaakov Maman Amanda Day Tanya T. Paull André Nussenzweig
author_facet	Jacob Paiano Wei Wu Shintaro Yamada Nicholas Sciascia Elsa Callen Ana Paola Cotrim Rajashree A. Deshpande Yaakov Maman Amanda Day Tanya T. Paull André Nussenzweig
author_sort	Jacob Paiano
title	ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis
title_short	ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis
title_full	ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis
title_fullStr	ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis
title_full_unstemmed	ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis
title_sort	atm and prdm9 regulate spo11-bound recombination intermediates during meiosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fe2f3dab8f70455daf145802e93451d5
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ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis

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