Maternal blood count parameters of chronic inflammation by gestational age and their associations with risk of preterm delivery in the Japan Environment and Children’s Study

Maternal blood count parameters of chronic inflammation by gestational age and their associations with risk of preterm delivery in the Japan Environment and Children’s Study

Abstract Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR), are three reportedly predictive biomarkers that reflect subclinical chronic inflammatory burden. However, how these biomarkers change during pregnancy and its clinical utility am...

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Autores principales: Naho Morisaki, Aurélie Piedvache, Chie Nagata, Takehiro Michikawa, Seiichi Morokuma, Kiyoko Kato, Masafumi Sanefuji, Eiji Shibata, Mayumi Tsuji, Masayuki Shimono, Shouichi Ohga, Koichi Kusuhara, Japan Environment and Children’s Study Group
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/fe306cf59d7745e0ad8eabb8676f1a07
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spelling oai:doaj.org-article:fe306cf59d7745e0ad8eabb8676f1a072021-12-02T16:24:22ZMaternal blood count parameters of chronic inflammation by gestational age and their associations with risk of preterm delivery in the Japan Environment and Children’s Study10.1038/s41598-021-93101-22045-2322https://doaj.org/article/fe306cf59d7745e0ad8eabb8676f1a072021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93101-2https://doaj.org/toc/2045-2322Abstract Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR), are three reportedly predictive biomarkers that reflect subclinical chronic inflammatory burden. However, how these biomarkers change during pregnancy and its clinical utility among pregnant women have been rarely studied. Among 76,853 singleton pregnancies delivered at 28–41 weeks of gestation that were enrolled in the Japan Environment and Children’s Study, we observed the distribution of maternal NLR, PLR, and LMR values from week 0 to week 36 using spline curves, as well as their predictive values for preterm delivery with and without hypertensive disorders in pregnancy, placental abruption and intrauterine growth restriction (collectively termed ischemic placental disease due to their shared pathological and pathophysiological features) for measurements at 8–11 weeks, 12–17 weeks, and 18–21 weeks. NLR and PLR increased, whereas LMR decreased, with increasing gestation. High LMR and low NLR observed at 18–21 weeks, but not at earlier gestations, were associated with higher risk of preterm delivery with IPD (odds ratio 1.80 [95% CI 1.02, 3.19] per log[LMR]; odds ratio 0.49 [95% CI 0.29, 0.82] per log[NLR]). All parameters were not predictive of preterm delivery without IPD. We provide a robust reference curve for maternal blood count parameters NLR, PLR, and LMR by gestational week.Naho MorisakiAurélie PiedvacheChie NagataTakehiro MichikawaSeiichi MorokumaKiyoko KatoMasafumi SanefujiEiji ShibataMayumi TsujiMasayuki ShimonoShouichi OhgaKoichi KusuharaJapan Environment and Children’s Study GroupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Naho Morisaki
Aurélie Piedvache
Chie Nagata
Takehiro Michikawa
Seiichi Morokuma
Kiyoko Kato
Masafumi Sanefuji
Eiji Shibata
Mayumi Tsuji
Masayuki Shimono
Shouichi Ohga
Koichi Kusuhara
Japan Environment and Children’s Study Group
Maternal blood count parameters of chronic inflammation by gestational age and their associations with risk of preterm delivery in the Japan Environment and Children’s Study
description Abstract Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR), are three reportedly predictive biomarkers that reflect subclinical chronic inflammatory burden. However, how these biomarkers change during pregnancy and its clinical utility among pregnant women have been rarely studied. Among 76,853 singleton pregnancies delivered at 28–41 weeks of gestation that were enrolled in the Japan Environment and Children’s Study, we observed the distribution of maternal NLR, PLR, and LMR values from week 0 to week 36 using spline curves, as well as their predictive values for preterm delivery with and without hypertensive disorders in pregnancy, placental abruption and intrauterine growth restriction (collectively termed ischemic placental disease due to their shared pathological and pathophysiological features) for measurements at 8–11 weeks, 12–17 weeks, and 18–21 weeks. NLR and PLR increased, whereas LMR decreased, with increasing gestation. High LMR and low NLR observed at 18–21 weeks, but not at earlier gestations, were associated with higher risk of preterm delivery with IPD (odds ratio 1.80 [95% CI 1.02, 3.19] per log[LMR]; odds ratio 0.49 [95% CI 0.29, 0.82] per log[NLR]). All parameters were not predictive of preterm delivery without IPD. We provide a robust reference curve for maternal blood count parameters NLR, PLR, and LMR by gestational week.
format article
author Naho Morisaki
Aurélie Piedvache
Chie Nagata
Takehiro Michikawa
Seiichi Morokuma
Kiyoko Kato
Masafumi Sanefuji
Eiji Shibata
Mayumi Tsuji
Masayuki Shimono
Shouichi Ohga
Koichi Kusuhara
Japan Environment and Children’s Study Group
author_facet Naho Morisaki
Aurélie Piedvache
Chie Nagata
Takehiro Michikawa
Seiichi Morokuma
Kiyoko Kato
Masafumi Sanefuji
Eiji Shibata
Mayumi Tsuji
Masayuki Shimono
Shouichi Ohga
Koichi Kusuhara
Japan Environment and Children’s Study Group
author_sort Naho Morisaki
title Maternal blood count parameters of chronic inflammation by gestational age and their associations with risk of preterm delivery in the Japan Environment and Children’s Study
title_short Maternal blood count parameters of chronic inflammation by gestational age and their associations with risk of preterm delivery in the Japan Environment and Children’s Study
title_full Maternal blood count parameters of chronic inflammation by gestational age and their associations with risk of preterm delivery in the Japan Environment and Children’s Study
title_fullStr Maternal blood count parameters of chronic inflammation by gestational age and their associations with risk of preterm delivery in the Japan Environment and Children’s Study
title_full_unstemmed Maternal blood count parameters of chronic inflammation by gestational age and their associations with risk of preterm delivery in the Japan Environment and Children’s Study
title_sort maternal blood count parameters of chronic inflammation by gestational age and their associations with risk of preterm delivery in the japan environment and children’s study
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/fe306cf59d7745e0ad8eabb8676f1a07
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